[1]何小寒,刘桂琴,蒋丽琼,等.甲状腺相关眼病患者和正常人眼眶脂肪组织中脂肪特异性磷脂酶A2的表达[J].眼科新进展,2016,36(9):841-843.[doi:10.13389/j.cnki.rao.2016.0225]
　HE Xiao-Han,LIU Gui-Qin,JIANG Li-Qiong,et al.Expression of AdPLA in orbital adipose tissue of normal and patients with thyroid associated ophthalmopathy[J].Recent Advances in Ophthalmology,2016,36(9):841-843.[doi:10.13389/j.cnki.rao.2016.0225]
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甲状腺相关眼病患者和正常人眼眶脂肪组织中脂肪特异性磷脂酶A2的表达
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年9期
页码:
841-843
栏目:
应用研究
出版日期:
2016-09-05

文章信息/Info

Title:
Expression of AdPLA in orbital adipose tissue of normal and patients with thyroid associated ophthalmopathy
作者:
何小寒; 刘桂琴; 蒋丽琼; 欧阳明; 马大卉; 祝天辉
518040　广东省深圳市，深圳华侨城医院眼科（何小寒）；518040　广东省深圳市，深圳市眼科医院，深圳眼科学重点实验室深圳大学眼视光学院（刘桂琴，蒋丽琼，欧阳明，马大卉，祝天辉）
Author(s):
HE Xiao-Han;  LIU Gui-Qin ;  JIANG Li-Qiong;  OU-YANG Ming ;  MA Da-Hui; ZHU Tian-Hui
Department of Ophthalmology, Shenzhen Overseas Chinese Town Hospital ( HE Xiao-Han ) . Shenzhen 518040 , Guangdong Province , China ; The .Shenzhen Eye Hospital , Shenzhen Laboratory of Ophthalmology, Affiliated Shenzhen Eye Hospital of Shenzhen University ( LIU Gui-Qin, JIANG Li-Qiong, OU-YANG Ming, MA Da-Hui, ZHU Tian-Hui ) , Shenzhen 518040 , Guangdong Province , China
关键词:
甲状腺相关眼病; 眼球突出; 脂肪水解; 脂肪特异性磷脂酶A2
Keywords:
thyroid related ophthalmopathy ;  exophthalmos ; lipolysis ;  adipose-specific phospholipase A2
分类号:
Ｒ７７７.５
DOI:
10.13389/j.cnki.rao.2016.0225
文献标志码:
A
摘要:
目的　测量甲状腺相关眼病患者和正常人眼眶脂肪组织中脂肪特异性磷脂酶Ａ２（ａｄｉｐｏｓｅ-ｓｐｅｃｉｆｉｃｐｈｏｓｐｈｏｌｉｐａｓｅＡ２，ＡｄＰＬＡ）的表达水平。方法　用实时定量聚合酶链反应定量检测３例甲状腺相关眼病患者和４例正常人眼眶脂肪组织的ＡｄＰＬＡｍＲＮＡ的表达水平。结果　甲状腺相关眼病患者眼眶脂肪组织中ＡｄＰＬＡｍＲＮＡ的表达量为０．０８８８２±０．０１３９１（中位数０．８２２００），正常人眼眶脂肪组织中ＡｄＰＬＡｍＲＮＡ的表达量为０．０１２１９±０．０５１２９（中位数０．００８７６），两组差异有统计学意义（Ｐ＜０．０５）。结论　ＡｄＰＬＡｍＲＮＡ在甲状腺相关眼病患者和正常人眼眶脂肪组织中均有表达，而且甲状腺相关眼病患者的表达量明显高于正常人。
Abstract:
Objective To detect the expression level of adipose-specific phospholipase A2 ( AdPLA) in orbital adipose tissue of patients with thyroid associated ophthalmopathy ( TAO) and the normal. Methods Using real time PCR, AdPLA mRNA was detected from orbital fat samples of 3 patients with TAO and 4 normal persons. Results The average expression level of AdPLA mRNA in patients with TAO was 0. 088 82 +0. 013 91 ( median 0. 822 00) ,in normal person was 0. 012 19 +0. 051 29 ( median 0. 008 76) , and there was significant difference between two groups (P < 0. 05 ) . Conclusion AdPLA mRNA is expressed in orbital adipose tissue of patients with TAO and the normal. and much more in patients with TAO than in the normal.

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备注/Memo

备注/Memo:
广东省中医药局科研课题（编号：２０１２２０２９、２０１３１０４１）；深圳市科技创新委课题（编号：ＪＣＹＪ２０１４０４１４１１４８５３６４８）
更新日期/Last Update: 2016-09-09