[1]金珂,朱豫. 甲状腺相关眼病患者干眼症患病率及特征分析[J].眼科新进展,2015,35(5):473-475.[doi:10.13389/j.cnki.rao.2015.0129]
　JIN Ke,ZHU Yu. Analysis of prevalence and characteristic of dry eye in patients with thyroid associated ophthalmopathy[J].Recent Advances in Ophthalmology,2015,35(5):473-475.[doi:10.13389/j.cnki.rao.2015.0129]
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 甲状腺相关眼病患者干眼症患病率及特征分析
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年5期
页码:
473-475
栏目:
应用研究
出版日期:
2015-05-05

文章信息/Info

Title:
 Analysis of prevalence and characteristic of dry eye in patients with thyroid associated ophthalmopathy
作者:
 金珂; 朱豫    
 450052　河南省郑州市，郑州大学第一附属医院眼科
Author(s):
 JIN Ke; ZHU Yu
 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052 , Henan Province , China
关键词:
 ; 甲状腺相关眼病; 干眼症; 患病率
Keywords:
 ; thyroid associated ophthalmopathy ;  dry eye ; morbidity
DOI:
10.13389/j.cnki.rao.2015.0129
文献标志码:
A
摘要:
 目的　探讨甲状腺相关眼病（ｔｈｙｒｏｉｄａｓｓｏｃｉａｔｅｄｏｐｈｔｈａｌｍｏｐａｔｈｙ，ＴＡＯ）患者干眼症的患病率及不同时期干眼症患病率的差异和特征。方法　收集２０１４年１月至２０１４年１２月２８１例ＴＡＯ患者的资料，包括症状、泪液分泌试验（ＳｃｈｉｒｍｅｒＩｔｅｓｔ，ＳＩｔ）、泪膜破裂时间（ｂｒｅａｋ-ｕｐｔｉｍｅ，ＢＵＴ）及角膜荧光素染色（ｆｌｕｏｒｅｓｃｅｎｔｓｔａｉｎｉｎｇ，ＦＳ）的结果。按照ＴＡＯ临床活动度评分（ｃｌｉｎｉｃａｌａｃ-ｔｉｖｉｔｙｓｃｏｒｅ，ＣＡＳ），将患者分为活动期（ＣＡＳ≥４分）和非活动期（ＣＡＳ＜４分），根据ＴＡＯ病程将患者分为短病程组（＜１ａ）、中病程组（≥１～２ａ）、长病程组（≥２ａ）。分析干眼症患病率及特征。结果　本组２８１例ＴＡＯ患者干眼症患病率６５．４８％。活动期和非活动期干眼症患病率分别为７７．０８％和５９．４６％（χ２ ＝８．６８５，Ｐ＝０．００３），ＳＩｔ、ＢＵＴ及ＦＳ评分差异均有统计学意义（均为Ｐ＜０．０５）。短病程组和长病程组干眼症患病率分别为６８．８９％和５０．９１％（χ２＝５．９６１，Ｐ＝０．０１５），病程越长ＦＳ评分越小，ＦＳ评分差异有统计学意义（Ｐ＜０．０５），但ＳＩｔ及ＢＵＴ组间差异均无统计学意义（均为Ｐ＞０．０５）。结论　ＴＡＯ患者干眼症患病率高，活动期和非活动期、不同病程时期患病率存在差异。病程在２ａ以上者干眼症患病率降低。
Abstract:
 Objective To observe the prevalence of dry eye in patients with thyroid associated ophthalmopathy ( TAO) . and investigate the discrepancy and characteristics of dry eye in different stages. Methods A total of 281 TAO patients in our hospital from January to December in 2014 were collected. Symptoms , Schirmer I test ( SIt ) , tear break-up time ( BUT) and corneal fluorescent stairung ( FS) were recorded. According to the clinical activity score ( CAS) ,the patients were divided into two groups as TAO active period group ( CAS；4 points , 96 cases) and TAO inactive period goup ( CAS < 4 points , 185 cases) . According to the duration of the disease , the patients were divided into three groups as short duration group 《 I year,180 cases) , middle duration group ( I - 2 years ,46 cases) and long duration goup ( >2 years,55 cases). The prevalence and characteristics of dry eye were analyzed. Results The prevalence of dry eye was 65. 48% in 281 patients. The prevalence of TAO active period and TAO inactive period were 77. 08% and 59. 46% , respectively (X2 = 8. 685 , P = 0. 003 ) . and there were statistical differences in SIt.BUT and FS score ( all P < 0. 05). The prevalence of short and long duration were 68. 8g% and 50. 91% ,respectively (X2 = 5. 961 ,P = 0. 015 ) , and there was statistical difference in FS score (P < 0. 05 ) .but there was no statistical difference in SIt and BUT( all P > 0. 05) . Conclusion The prevalence of dry eye in TAO patients is high , there are different in TAO active . inactive period and different course. The prevalence of dry eye reduce in the patients with duration more than 2 years.

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更新日期/Last Update: 2015-04-27