[1]江选峰,刘璟禹,董凌峰,等.MEDPOR种植体作为巩膜外黄斑垫压物的组织相容性、血管化进程及对眼部功能影响的实验研究[J].眼科新进展,2016,36(8):712-715.[doi:10.13389/j.cnki.rao.2016.0189]
　JIANG Xuan-Feng,LIU Jing-Yu,DONG Ling-Feng,et al.Investigate the histocompatibility and effects on ocular function of MEDPOR implant as macular scleral buckling[J].Recent Advances in Ophthalmology,2016,36(8):712-715.[doi:10.13389/j.cnki.rao.2016.0189]
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MEDPOR种植体作为巩膜外黄斑垫压物的组织相容性、血管化进程及对眼部功能影响的实验研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年8期
页码:
712-715
栏目:
实验研究
出版日期:
2016-08-05

文章信息/Info

Title:
Investigate the histocompatibility and effects on ocular function of MEDPOR implant as macular scleral buckling
作者:
江选峰; 刘璟禹; 董凌峰; 姚进; 蒋沁
210000　江苏省南京市，南京医科大学眼科医院
Author(s):
JIANG Xuan-Feng ;  LIU Jing-Yu ;  DONG Ling-Feng;  YAO Jin ; JIANG Qin
Eye Hospital Affiliated to Nanjing Medical University, Nanjing 210000 , Jiangsu Province , China
关键词:
MEDPOR种植体; 硅胶海绵; 异体巩膜; 黄斑外垫压; 组织相容性
Keywords:
MEDPOR ;  silicone sponge ;  allogeneic sclera;  macular scleral buckling ;  histocompatibility
分类号:
Ｒ７７２.３
DOI:
10.13389/j.cnki.rao.2016.0189
文献标志码:
A
摘要:
目的　探讨ＭＥＤＰＯＲ种植体、硅胶海绵及异体巩膜作为巩膜外黄斑垫压物组织相容性、血管化进程及对眼部功能的影响以选择最佳外垫压物。方法　成年新西兰白兔２４只，随机分４组：Ａ组左眼植入硅胶海绵、Ｂ组左眼植入异体巩膜包裹硅胶海绵、Ｃ组左眼植入ＭＥＤＰＯＲ、Ｄ组左眼植入异体巩膜包裹ＭＥＤＰＯＲ，右眼均为对照眼。分别在术前及术后不同时间对植入物的组织相容性及对眼球功能影响进行检测。结果　实验Ｃ组和Ｄ组，ＭＥＤＰＯＲ与周围组织附着紧密，形成有效加压嵴，其内有纤维组织长入，血管化良好。Ｄ组中异体巩膜包裹ＭＥＤＰＯＲ，避免了ＭＥＤＰＯＲ对周围组织损伤，减轻了炎症反应。实验Ａ组和Ｂ组植入硅胶海绵与周围组织附着疏松，无纤维组织长入。各实验组植入外加压材料后对眼部功能均无明显影响。结论　ＭＥＤＰＯＲ＋异体巩膜有良好的刚性，能形成有效的巩膜加压嵴，组织相容性好，组织损伤小，是理想的外加压材料。
Abstract:
Objective To investigate the histocompatibility and effects on ocular function of MEDPOR implant, silicone sponge and allogeneic sclera as macular scleral buckling , and select the better scleral buckling. Methods Twenty-four adult New Zealand white rabbits were divided into four groups ( A,B,C ,D) at random. The left eyes of group A, B. C . D were implanted with silicone sponge, silicone sponge + allogeneic sclera.MEDPOR and MEDPOR + allogeneic sclera, respectively, and the right eye as control. The effects on the ocular function . buckle heights , samples in general morphology and light microscope were evaluated in pre-operation and I month,2 months . and 4 months after operation. Results In group C and D, MEDPOR was adhered to surrounding tissue tightly with fiber tissue growing in, and good vascularization. In group D , allogeneic sclera implant showed the less inflammation , but with degradation partly. In group A and B , silicone sponge adhered to surrounding tissue loosely , with no fiber tissue ingrowth. The buckle heights by medpor lasted for the whole experiment. Conclusion MEDPOR plus allogeneic sclera has good histocompatibility , rigidity and less inflammatory reaction . which is suitable for macular scleral buckling implant.

相似文献/References:

[1]石莲军,张苏,徐向忠,等.巩膜外黄斑外垫压术治疗硅油填充术后复发性超高度近视黄斑裂孔性视网膜脱离[J].眼科新进展,2019,39(3):267.[doi:10.13389/j.cnki.rao.2019.0060]
　SHI Lian-Jun,ZHANG Su,XU Xiang-Zhong,et al.Macular scleral buckle for recurrent macular hole retinal detachment after vitrectomy with silicone oil tamponade in ultra-high myopia eyes[J].Recent Advances in Ophthalmology,2019,39(8):267.[doi:10.13389/j.cnki.rao.2019.0060]

备注/Memo

备注/Memo:
江苏省六大人才高峰项目（编号：ＷＳ-０７３）；南京市医学科技项目（编号：ＺＫＸ１２０４７）；江苏省“青蓝工程”项目资助（苏教师［２０１２］３９号）
更新日期/Last Update: 2016-08-22