[1]叶子,李朝辉,何守志.丛生蛋白参与年龄相关性黄斑变性的作用机制[J].眼科新进展,2015,35(11):1087-1089.[doi:10.13389/j.cnki.rao.2015.0298]
 YE Zi,LI Zhao-Hui,HE Shou-Zhi.Action mechanism of clusterin in age-related macular degeneration[J].Recent Advances in Ophthalmology,2015,35(11):1087-1089.[doi:10.13389/j.cnki.rao.2015.0298]
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丛生蛋白参与年龄相关性黄斑变性的作用机制
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年11期
页码:
1087-1089
栏目:
文献综述
出版日期:
2015-11-05

文章信息/Info

Title:
Action mechanism of clusterin in age-related macular degeneration
作者:
叶子李朝辉何守志
100853 北京市,北京市解放军总医院眼科
Author(s):
YE ZiLI Zhao-HuiHE Shou-Zhi
Department of Ophthalmology , the PLA General Hospital , Beijing 100853 , China
关键词:
年龄相关性黄斑变性视网膜色素上皮细胞丛生蛋白
Keywords:
age-related macular degenerationretinal pigment epithelial cell clusterin
DOI:
10.13389/j.cnki.rao.2015.0298
文献标志码:
A
摘要:
丛生蛋白是玻璃膜疣的主要蛋白成分之一。近年来研究发现丛生蛋白与衰老密切相关,不仅通过对补体系统的调节参与年龄相关性黄斑变性(age-relatedmaculardegen-eration,AMD)炎症反应发生机制,也与氧化还原反应密切相关,是AMD发生过程中氧化应激反应的感受器。本文就丛生蛋白参与AMD作用机制的研究进展进行综述。
Abstract:
Clusterin is one of the major component of drusen. In recent years , studies have found that clusterin is related to ageing. It is not only involved in inflammation mechanism in age-related macular degeneration ( AMD) through regulating the complement system . but also related with the oxidation reduction reaction, acting as a sensor for oxidative stress. This article reviews the research progress of clusterin protein in AMD,so as to find a new target for future therapy of AMD.

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备注/Memo

备注/Memo:
国家重点基础研究发展计划(编号:2011CB510200)
更新日期/Last Update: 2015-11-03