[1]黄华发,刘东成,秦波.铁死亡在年龄相关性黄斑变性中的调控机制研究进展[J].眼科新进展,2023,43(11):914-919.[doi:10.13389/j.cnki.rao.2023.0183]
　HUANG Huafa,LIU Dongcheng,QIN Bo.Advances in the regulatory mechanism of ferroptosis in age-related macular degeneration[J].Recent Advances in Ophthalmology,2023,43(11):914-919.[doi:10.13389/j.cnki.rao.2023.0183]
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铁死亡在年龄相关性黄斑变性中的调控机制研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年11期
页码:
914-919
栏目:
文献综述
出版日期:
2023-11-05

文章信息/Info

Title:
Advances in the regulatory mechanism of ferroptosis in age-related macular degeneration
作者:
黄华发; 刘东成; 秦波
518000　广东省深圳市，暨南大学第二临床医学院（黄华发，秦波）；518032　广东省深圳市，暨南大学附属爱尔眼科医院（深圳）（刘东成，秦波）；518000　广东省深圳市，深圳市爱尔眼科技术研究所（刘东成，秦波）
Author(s):
HUANG Huafa1; LIU Dongcheng2; 3; QIN Bo1; 2; 3
1.The Second Clinical Medical College of Ji’nan University,Shenzhen 518000, Guangdong Province,China
2.The Shenzhen Aier Eye Hospital Affiliated to Ji’nan University,Shenzhen 518032, Guangdong Province,China
3.The Shenzhen Aier Ophthalmic Technology Institute,Shenzhen 518000,Guangdong Province,China
关键词:
铁死亡; 年龄相关性黄斑变性; 视网膜色素上皮细胞
Keywords:
ferroptosis;  age-related macular degeneration;  retinal pigment epithelial cell
分类号:
R774.5
DOI:
10.13389/j.cnki.rao.2023.0183
文献标志码:
A
摘要:
目的　铁死亡是一种以脂质过氧化为特征的调节性细胞死亡，在年龄相关性黄斑变性（AMD）中扮演重要角色。本文就AMD的病理机制、铁死亡过程及特征进行回顾，并从铁离子代谢途径、胱氨酸/谷氨酸逆向转运体途径、脂质代谢途径、核转录因子途径、自噬依赖性途径及免疫相关途径对铁死亡在AMD发生发展中的调控机制进行论述，最后归纳总结部分铁死亡抑制剂对视网膜色素上皮细胞的保护作用，为AMD的治疗提供新的思路。
Abstract:
Ferroptosis, a kind of regulated cell death characterized by lipid peroxidation, plays an important role in age-related macular degeneration (AMD). This article reviews the pathogenesis of AMD, ferroptosis process and characteristics, discusses the regulatory mechanism of ferroptosis in the occurrence and development of AMD from the iron metabolism pathway, cystine/glutamate reverse transporter pathway, lipid metabolism pathway, nuclear transcription factor pathway, autophagy-dependent pathway and immune-related pathway, and summarizes the protective effect of some ferroptosis inhibitors on retinal pigment epithelial cells, providing a new idea for the treatment of AMD.

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备注/Memo

备注/Memo:
广东省自然科学基金（编号：2022A1515010742）；爱尔眼科医院集团科研基金（编号AM2101D1）
更新日期/Last Update: 2023-11-05