[1]傅维娜,陈梅珠,王云鹏. Lucentis联合视网膜光凝治疗视网膜分支静脉阻塞继发黄斑水肿[J].眼科新进展,2015,35(3):270-273.[doi:10.13389/j.cnki.rao.2015.0072]
　FU Wei-Na,CHEN Mei-Zhu,WANG Yun-Peng. Intravitreal injection with lucentis combined with local retinal photocoagulation for macular edema secondary to branch retinal vein occlusion[J].Recent Advances in Ophthalmology,2015,35(3):270-273.[doi:10.13389/j.cnki.rao.2015.0072]
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 Lucentis联合视网膜光凝治疗视网膜分支静脉阻塞继发黄斑水肿
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年3期
页码:
270-273
栏目:
应用研究
出版日期:
2015-03-05

文章信息/Info

Title:
 Intravitreal injection with lucentis combined with local retinal photocoagulation for macular edema secondary to branch retinal vein occlusion
作者:
 傅维娜; 陈梅珠; 王云鹏
 350025　福建省福州市，南京军区福州总医院眼科、厦门大学附属东方医院眼科
Author(s):
 FU Wei-Na; CHEN Mei-Zhu; WANG Yun-Peng
 Department of Ophthalmology, Fuzhou GeneraL Hospital of Nanjing Military Command, Dongfang Hospital Affiliated to Xiamen University, Fuzhou 350025 , Fujian Province , China
关键词:
 ; 视网膜分支静脉阻塞; 黄斑水肿; Lucentis; 多焦视网膜电图
Keywords:
 ; branch retinal vein occlusion;  macular edema;  lucentis ;  multifocal electroretinogram
DOI:
10.13389/j.cnki.rao.2015.0072
文献标志码:
A
摘要:
 目的　观察玻璃体内注射Ｌｕｃｅｎｔｉｓ联合局部视网膜光凝治疗视网膜分支静脉阻塞（ｂｒａｎｃｈｒｅｔｉｎａｌｖｅｉｎｏｃｃｌｕｓｉｏｎ，ＢＲＶＯ）合并黄斑水肿的疗效。方法　回顾性分析我院ＢＲ-ＶＯ合并黄斑水肿的患者２４例２４眼，予以玻璃体内注射１０ｇ?Ｌ－１Ｌｕｃｅｎｔｉｓ０．０５ｍＬ１次，７ｄ后行局部视网膜光凝。观察联合治疗前与治疗后１个月最佳矫正视力、黄斑中心凹区视网膜厚度（ｃｅｎｔｒａｌｍａｃｕｌａｒｔｈｉｃｋｎｅｓｓ，ＣＭＴ）、Ｐ１波的振幅密度及潜伏期的变化。结果　联合治疗前最佳矫正视力为０．１３±０.１０，治疗后１个月为０．２９±０．２１，较治疗前明显提高（Ｐ＜０．０１），其中１３眼（５４．２％）最佳矫正视力提高３行。联合治疗前黄斑中心凹厚度为（５８５±１５４）μｍ，治疗后黄斑中心凹厚度降为（３８３±１７３）μｍ（Ｐ＜０．０１）。联合治疗后１环、２环、３环Ｐ１波振幅密度均较治疗前明显提高，潜伏期均明显缩短，差异均有统计学意义（均为Ｐ＜０．０５）。玻璃体内注射后３眼出现结膜下出血，１眼白内障加重。结论　玻璃体内注射Ｌｕｃｅｎｔｉｓ联合视网膜局部光凝治疗ＢＲＶＯ合并黄斑水肿，可快速降低ＣＭＴ，提高视力，并发症少。
Abstract:
 Objective To observe the efficacy of intravitreal injection with lucentis combined with local retinal photocoagulation for macular edema ( ME) secondary to branch retinal vein occlusion ( BRVO) . Methods A retrospective analysis of 24 patients ( 24 eyes) with ME secondary to BRVO were taken. The intravitreal injection with lucentis 0. 05 mL( 10 g . L") was once given, after 7 days the standard local retinal photocoagulation was performed. The changes of best corrected visual acuity ( BCVA) , central macular thickness ( CMT) , and amplitude density and latency of Pl wave were observed before treatment and I month after treatment. Results Before the combined treatment.BCVA was 0. 13 +0. 10 , I month after treatment was 0. 29 +0. 21 . the BCVA was improved obviously( P < 0. 01) . BCVA in 13 patients ( 54. 2% ) were improved in three rows among all the patients. CMT before treatment was ( 585 + 154) ym, after treatment was ( 383 + 173 ) Vm ( P < 0. 01 ) . The amplitude densities of Pl wave in ring l , ring 2 and ring 3 after treatment were significantly increased. and the latencies were decreased ( all P < 0. 05 ) . The conjunctival hemorrhage were observed in 3 eyes after treatment,and the cataract in I eye was aggravated. Conclusions Intravitreal injection with lucentis combined with local retinal photocoagulation for ME secondary to BRVO can immediately reduce the CMT and improve visual function. at the same time. the complication is rare.

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　DONG Ning,TANG Xin,XIAO Lin,et al. Acute and convalescent changes in plasma homocysteine concentrations in branch retinal vein occlusion[J].Recent Advances in Ophthalmology,2015,35(3):368.[doi:10.13389/j.cnki.rao.2015.0099]

备注/Memo

备注/Memo:
 福建省科学技术厅基金资助（编号：２０１２Ｙ００５５）
更新日期/Last Update: 2015-03-04