[1]董宁,汤欣,肖林,等. 视网膜分支静脉阻塞患者急性期和恢复期血浆同型半胱氨酸水平的变化[J].眼科新进展,2015,35(4):368-370.[doi:10.13389/j.cnki.rao.2015.0099]
　DONG Ning,TANG Xin,XIAO Lin,et al. Acute and convalescent changes in plasma homocysteine concentrations in branch retinal vein occlusion[J].Recent Advances in Ophthalmology,2015,35(4):368-370.[doi:10.13389/j.cnki.rao.2015.0099]
点击复制

 视网膜分支静脉阻塞患者急性期和恢复期血浆同型半胱氨酸水平的变化
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年4期
页码:
368-370
栏目:
应用研究
出版日期:
2015-04-05

文章信息/Info

Title:
 Acute and convalescent changes in plasma homocysteine concentrations in branch retinal vein occlusion
作者:
 董宁; 汤欣; 肖林; 徐冰
 300020　天津市，天津医科大学眼科临床学院，天津市眼科医院，天津市眼科研究所，天津市眼科学与视觉科学重点实验室
Author(s):
 DONG Ning ; TANG Xin ; XIAO Lin ; XU Bing
 Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin 300020,China
关键词:
 ; 急性期; 恢复期; 视网膜分支静脉阻塞; 血浆同型半胱氨酸
Keywords:
 ; acute phase;  convalescent period;  branch retinal vein occlusion;  plasma homocysteine
DOI:
10.13389/j.cnki.rao.2015.0099
文献标志码:
A
摘要:
 目的　探讨视网膜分支静脉阻塞（ｂｒａｎｃｈｒｅｔｉｎａｌｖｅｉｎｏｃｃｌｕｓｉｏｎ，ＢＲＶＯ）患者急性期及恢复期血浆同型半胱氨酸（ｈｏｍｏｃｙｓｔｅｉｎｅ，Ｈｃｙ）水平的变化。方法　连续收集４２例ＢＲＶＯ患者作为观察对象，选择４２名年龄、性别与观察对象相匹配的、无其他影响Ｈｃｙ病史的非视网膜疾病患者作为对照组。ＢＲＶＯ发生后３ｄ、１个月、３个月、６个月抽取ＢＲＶＯ患者的空腹静脉血，对照组抽取单次空腹血，采用高效液相色谱荧光检测法检测Ｈｃｙ，用放射免疫法测定维生素Ｂ１２、叶酸水平，Ｃ６７７ＴＭＴＨＦＲ基因多态性采用聚合酶链反应进行分析。结果　ＢＲＶＯ患者阻塞发生后３ｄＨｃｙ水平（１１．０１±４．０９）μｍｏｌ?Ｌ－１与对照组（１０．０４±３．６７）μｍｏｌ?Ｌ－１相比，差异无统计学意义（Ｐ＝０．２５７）。ＢＲＶＯ患者的Ｈｃｙ水平在发生阻塞后逐渐升高，ＢＲＶＯ发生后１个月Ｈｃｙ达到高峰（１３．２７±５．８１）μｍｏｌ?Ｌ－１，６个月时下降到正常水平（１１．１７±４．３６）μｍｏｌ?Ｌ－１。同时，ＢＲＶＯ患者Ｈｃｙ水平在ＢＲＶＯ发生后３ｄ（ｒ＝０．３４３）、１个月（ｒ＝０．３８１）、３个月（ｒ＝０．４３２）、６个月（ｒ＝０．３６０）都与黄斑区视网膜厚度呈显著的正相关（均为Ｐ＜０．０５）。然而，ＢＲＶＯ患者Ｈｃｙ水平的变化与维生素Ｂ１２、叶酸水平以及Ｃ６７７ＴＭＴＨＦＲ基因多态性无关（均为Ｐ＞０．０５）。结论　患者发生ＢＲＶＯ后Ｈｃｙ水平一过性升高，本研究结果不支持Ｈｃｙ是ＢＲＶＯ的独立危险因素的推测，然而Ｈｃｙ水平的变化可能是疾病本身引起的。
Abstract:
 Objective To measure fasting total plasma homocysteine ( Hcy) concentrations immediately after branch retinal vein occlusion ( BRVO ) and in the convalescent period to investigate this controversy. Methods Hcy concentrations in 42 consecutive patients with BRVO were measured at 3 days, I month. 3 months and 6 months after BRVO and once in 42 control subjects. The vitanun B12 , and folate levels and presence of C677T MTHFR polymorphisms were analyzed in all patients and controls. Results Hcy concentrations at 3 days after BRVO ( 11. 01 +4. 09) Vmol . L-I was not sigruficantly higher than that in matched control subjects ( 10. 04 + 3. 67 ) ymol . L-1 (P = 0. 257) . However, Hcy levels increased gradually after BRVO . reached a peak at I month after BRVO ( 13. 27 +5. 81) ymol . L-I , and declined to the normal values at 6 months after BRVO. In addition , Hcy levels were correlated with the macular retinal thickness , and this correlation was significant at all time points ( r = 0. 343 . 0. 381 . 0. 432 , 0. 360 ; all P < 0. 05 ) . However, Hcy level changes was not correlated with serum folate, vitamin Biz concentrations and MTHFR C677T genotype. Conclusion Hcy levels are not immediately elevated after BRVO but transiently increase in the convalescent period. These data do not support the hypothesis that raised Hcy concentrations are an independent risk factor for BRVO. Instead, it is possible that changed Hcy levels may be caused by the disease process itself.

相似文献/References:

[1]刘平 苏胜. 白内障蛋白质组学研究的现状及未来研究方向[J].眼科新进展,2014,34(1):001.
[2]杨宝娣 宋艳萍 陈中山 丁琴. 微脉冲半导体激光对兔视网膜色素上皮细胞阈值下光凝的光生物调制效应[J].眼科新进展,2014,34(1):005.
[3]赖伟霞 梁皓 谭少健 李霞 邹文进 蒋林志. 钙调素在正常人及不同年龄白内障患者晶状体上皮细胞中的表达[J].眼科新进展,2014,34(1):010.
[4]郑燕林 刘聪慧 沙菽. 水蛭提取液对体外培养RF/6A的细胞液中MMP-2、IV型胶原含量的影响[J].眼科新进展,2014,34(1):013.
[5]周琨 高晓唯 蔡岩 李文静 胡裕坤 田丽丽 付燕. CCR7基因修饰的未成熟树突状细胞在大鼠高危角膜移植免疫排斥反应中的作用[J].眼科新进展,2014,34(1):017.
[6]高伟 程燕 吴洁 王亮 赵帅. 肉毒杆菌B诱导大鼠干眼模型中泪腺Lacritin蛋白表达的研究[J].眼科新进展,2014,34(1):021.
[7]赵宁 张瑞君 刘磊 李佳 刘宁宁. PTEN基因对兔晶状体上皮细胞增殖抑制作用的实验研究[J].眼科新进展,2014,34(1):025.
[8]陈雪 李海平 张培 曹安民. 小胶质细胞在视网膜母细胞瘤中的活化及分布研究[J].眼科新进展,2014,34(1):029.
[9]李琴 谢婷玉 陈雪艺 王清 郭乔茜 具尔提·哈第尔. 臭氧灌肠改善糖尿病大鼠的视网膜电图表现[J].眼科新进展,2014,34(1):034.
[10]蔡晶晶 孟倩丽 郭海科 张良 李东风 崔颖. 血红素加氧酶-1在糖尿病视网膜病变患者外周血单个核细胞中的表达[J].眼科新进展,2014,34(1):037.

更新日期/Last Update: 2015-03-31