[1]周涛,徐丽娟,韩佳伶,等.健康人和青光眼患者小梁网-Schlemm管的形态学特征[J].眼科新进展,2023,43(11):907-913.[doi:10.13389/j.cnki.rao.2023.0182]
　ZHOU Tao,XU Lijuan,HAN Jialing,et al.Morphological features of the trabecular meshwork-Schlemm’s canal pathway in healthy people and glaucoma patients[J].Recent Advances in Ophthalmology,2023,43(11):907-913.[doi:10.13389/j.cnki.rao.2023.0182]
点击复制

健康人和青光眼患者小梁网-Schlemm管的形态学特征/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年11期
页码:
907-913
栏目:
文献综述
出版日期:
2023-11-05

文章信息/Info

Title:
Morphological features of the trabecular meshwork-Schlemm’s canal pathway in healthy people and glaucoma patients
作者:
周涛; 徐丽娟; 韩佳伶; 冮晓睿; 梁远波
325027　浙江省温州市，温州医科大学附属眼视光医院（周涛，徐丽娟，韩佳伶，冮晓睿，梁远波）；325027　浙江省温州市，温州医科大学青光眼研究所（周涛，徐丽娟，韩佳伶，冮晓睿，梁远波）
Author(s):
ZHOU Tao1; 2; XU Lijuan1; 2; HAN Jialing1; 2; GANG Xiaorui1; 2; LIANG Yuanbo1; 2
1.The Eye Hospital of Wenzhou Medical University,Wenzhou 325027,Zhejiang Province,China
2.Glaucoma Research Institute of Wenzhou Medical University,Wenzhou 325027,Zhejiang Proince,China
关键词:
青光眼; 小梁网; Schlemm管
Keywords:
glaucoma;  trabecular meshwork;  Schlemm’s canal
分类号:
R775
DOI:
10.13389/j.cnki.rao.2023.0182
文献标志码:
A
摘要:
房水循环障碍导致的眼压升高是青光眼发生发展的主要危险因素。小梁网-Schlemm管途径引流75%~80%的房水，其结构在不同生理条件下发生持续动态变化从而引起眼压波动。大量研究表明青光眼患者眼压升高与小梁网和Schlemm管形态改变之间关系紧密，但目前缺乏系统性综述。本文就健康人和多种类型青光眼患者中小梁网及Schlemm管的形态学特征进行综述，以期为青光眼发病机制、预防和治疗的进一步探究提供参考。
Abstract:
Elevated intraocular pressure (IOP) caused by aqueous humor circulation disorders is a main risk factor for the occurrence and development of glaucoma. The trabecular meshwork-Schlemm’s canal (TM-SC) pathway, which drains 75%-80% of aqueous humor, changes dynamically in the structure under different physiological conditions and thus leads to IOP fluctuation. Many studies have indicated a strong correlation between IOP elevation and morphological changes in the TM-SC pathway in glaucoma patients; however, there is a lack of systematic review. This article reviews the morphological features of the TM-SC pathway in healthy people and glaucoma patients, to provide references for further exploration into the pathogenesis, prevention and treatment of glaucoma.

参考文献/References:

［1］　THAM Y,LI X,WONG T Y,QUIGLEY H A,AUNG T,CHENG C.Global prevalence of glaucoma and projections of glaucoma burden through 2040:a systematic review and meta-analysis［J］.Ophthalmology,2014,121(11):2081-2090.
［2］　KUEHN M H,VRANKA J A,WADKINS D,JACKSON T,CHENG L,LEDOLTER J.Circumferential trabecular meshwork cell density in the human eye［J］.Exp Eye Res, 2021,205:108494.
［3］　ACOTT T S,VRANKA J A,KELLER K E,RAGHUNATHAN V,KELLEY M J.Normal and glaucomatous outflow regulation［J］.Prog Retin Eye Res,2021,82:100897.
［4］　KIM Y W,PARK K H.Exogenous influences on intraocular pressure［J］.Br J Ophthalmol,2019,103(9):1209-1216.
［5］　CROWELL E L,BAKER L,CHUANG A Z,FELDMAN R M,BELL N P,CHEVEZ-BARRIOS P,et al.Characterizing anterior segment OCT angle landmarks of the trabecular meshwork complex［J］.Ophthalmology,2018,125(7):994-1002.
［6］　SWAIN D L,LE T D,YASMIN S,FERNANDES B,LAMAJ G,DASGUPTA I,et al.Morphological factors associated with giant vacuoles with I-pores in Schlemm’s canal endothelial cells of human eyes:a serial block-face scanning electron microscopy study［J］.Exp Eye Res,2021,205:108488.
［7］　CHEN Z,SUN J,LI M,LIU S,CHEN L,JING S,et al.Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept-source optical coherence tomography［J］.Eye (Lond),2018,32(10):1621-1628.
［8］　FERNNDEZ-VIGO J I,GARCA-FEIJO J,MARTNEZ-DE-LA-CASA J M,GARCA-BELLA J,FERNáNDEZ-VIGO J A.Morphometry of the trabecular meshwork in vivo in a healthy population using fourier-domain optical coherence tomography［J］.Invest Ophthalmol Vis Sci,2015,56(3):1782-1788.
［9］　CHOI W,BAE H W,CHO H,KIM E W,KIM C Y,SEONG G J.Evaluation of the relationship between age and trabecular meshwork height to predict the risk of glaucoma［J］.Sci Rep,2020,10(1):7115.
［10］　ZHAO Y,CHEN J,YU X,XU J,SUN X,HONG J.Age-related changes in human schlemm’s canal:an in vivo optical coherence tomography-based study［J］.Front Physiol,2018,9:630.
［11］　MCMENAMIN P G,LEE W R,AITKEN D A.Age-related changes in the human outflow apparatus［J］.Ophthalmology,1986,93(2):194-209.
［12］　CRACKNELL K P B,GRIERSON I,HOGG P,MAJEKODUNMI A A,WATSON P,MARMION V.Melanin in the trabecular meshwork is associated with age,POAG but not latanoprost treatment.A masked morphometric study［J］.Exp Eye Res,2006,82(6):986-993.
［13］　HAMANAKA T,SAKURAI T,FUSE N,ISHIDA N,KUMASAKA T,TANITO M.Comparisons of schlemm’s canal and trabecular meshwork morphologies between juvenile and primary open angle glaucoma［J］.Exp Eye Res,2021,210:108711.
［14］　BOLDEA R C,ROY S,MERMOUD A.Ageing of schlemm’s canal in nonglaucomatous subjects［J］.Int Ophthalmol,2001,24(2):67-77.
［15］　SWAIN D L,YASMIN S,FERNANDES B,LAMAJ G,SU Y,GONG H.Schlemm’s canal endothelium cellular connectivity in giant vacuole and pore formation in different flow-type areas:a serial block-face scanning electron microscopy study［J］.Front Cell Dev Biol,2022,10:867376.
［16］　MORGAN J T,RAGHUNATHAN V K,CHANG Y,MURPHY C J,RUSSELL P.The intrinsic stiffness of human trabecular meshwork cells increases with senescence［J］.Oncotarget,2015,6(17):15362-15374.
［17］　DANIEL M C,DUBIS A M,QUARTILHO A,AL-HAYOUTI H,KHAW S,THEODOROU M,et al.Dynamic changes in schlemm canal and iridocorneal angle morphology during accommodation in children with healthy eyes:a cross-sectional cohort study［J］.Invest Ophthalmol Vis Sci,2018,59(8):3497-3502.
［18］　XIANG Y,CHEN L,ZHAO Y,CHEN W,CHEN Z,LIU S,et al.Measuring changes in schlemm’s canal and trabecular meshwork in different accommodation states in myopia children:an observational study［J］.Eye (Lond),2020,34(2):374-382.
［19］　CHEN L,JIN W,HAO X,LI X,XING Y.Dynamic changes of scleral spur length in different accommodation stimuli states［J］.Sci Rep,2021,11(1):18176.
［20］　QUARANTA L,KATSANOS A,RIVA I,DASTIRIDOU A,ODDONE F,ROBERTI G,et al.Twenty-four-hour intraocular pressure and ocular perfusion pressure characteristic in newly diagnosed patients with normal tension glaucoma［J］.Eye (Lond),2016,30(11):1481-1489.
［21］　LIU H,FAN S,GULATI V,CAMRAS L J,ZHAN G,GHATE D,et al.Aqueous humor dynamics during the day and night in healthy mature volunteers［J］.Arch Ophthalmol,2011,129(3):269-275.
［22］　LI M,ZHAO Y,YAN X,ZHANG H.The relationship between the 24-hour fluctuations in schlemm’s canal and intraocular pressure:an observational study using high-frequency ultrasound biomicroscopy［J］.Curr Eye Res,2017,42(10):1389-1395.
［23］　GAO K,LI F,AUNG T,ZHANG X.Diurnal variations in the morphology of schlemm’s canal and intraocular pressure in healthy chinese:an SS-OCT study［J］.Invest Ophthalmol Vis Sci,2017,58(13):5777-5782.
［24］　LI F,GAO K,LI X,CHEN S,HUANG W,ZHANG X.Anterior but not posterior choroid changed before and during Valsalva manoeuvre in healthy Chinese:a UBM and SS-OCT study［J］.Br J Ophthalmol,2017,101(12):1714-1719.
［25］　SUN L,CHEN W,CHEN Z,XIANG Y,GUO J,HU T,et al.Dual effect of the valsalva maneuver on autonomic nervous system activity,intraocular pressure,schlemm’s canal,and iridocorneal angle morphology［J］.BMC Ophthalmol,2020,20(1):5777-5782.
［26］　CHEN W,HU T,XU Q,CHEN Z,ZHANG H,WANG J.Acute effects of intraocular pressure-induced changes in schlemm’s canal morphology on outflow facility in healthy human eyes［J］.Invest Ophthalmol Vis Sci,2020,61(8):36.
［27］　YAN X,LI M,SONG Y,GUO J,ZHAO Y,CHEN W,et al.Influence of exercise on intraocular pressure,schlemm’s canal, and the trabecular meshwork［J］.Invest Ophthalmol Vis Sci,2016,57(11):4733-4739.
［28］　李木.运用光学相干层析成像技术观察运动对人眼前节结构影响的研究［D］.武汉:华中科技大学,2019.
LI M.The influence of exercise on the anterior segment biometrics of the eye using optical coherence tomography［D］.Wuhan:Huazhong Univ of Sci Technol,2019.
［29］　YUAN Y,LIN T,GAO K,ZHOU R,RADKE N V,LAM D,et al.Aerobic exercise reduces intraocular pressure and expands schlemm’s canal dimensions in healthy and primary open-angle glaucoma eyes［J］.Indian J Ophthalmol,2021,69(5):1127-1134.
［30］　ARORA N,MCLAREN J W,HODGE D O,SIT A J.Effect of body position on epsicleral venous pressure in healthy subjects［J］.Invest Ophthalmol Vis Sci,2017,58(12):5151-5156.
［31］　CHEN W,XIANG Y,DENG C,ZHANG H,WANG J.Analogs of microgravity:the function of schlemm’s canal,intraocular pressure and autonomic nervous during the head-down tilt test in healthy subjects［J］.Int J Ophthalmol,2021,14(9):1419-1423.
［32］　SELVADURAI D,HODGE D,SIT A J.Aqueous humor outflow facility by tonography does not change with body position［J］.Invest Ophthalmol Vis Sci,2010,51(3):1453-1457.
［33］　CHEN W,CHEN L,CHEN Z,XIANG Y,LIU S,ZHANG H,et al.Influence of the water-drinking test on intraocular pressure,schlemm’s canal,and autonomic nervous system activity［J］.Invest Ophthalmol Vis Sci,2018,59(8):3232-3238.
［34］　YAN X Q,LI M,CHEN Z Q,ZHOU X W.The anterior scleral thickness in eyes with primary open-angle glaucoma［J］.Graefes Arch Clin Exp Ophthalmol,2022,260(5):1601-1610.
［35］　YAN X,LI M,CHEN Z,ZHU Y,SONG Y,ZHANG H.Schlemm’s canal and trabecular meshwork in eyes with primary open angle glaucoma:a comparative study using high-frequency ultrasound biomicroscopy［J］.PLoS One,2016,11(1):e145824.
［36］　HONG J,XU J,WEI A,WEN W,CHEN J,YU X,et al.Spectral-domain optical coherence tomographic assessment of schlemm’s canal in Chinese subjects with primary open-angle glaucoma［J］.Ophthalmology,2013,120(4):709-715.
［37］　ALLINGHAM R R,DE KATER A W,ETHIER C R.Schlemm’s canal and primary open angle glaucoma:correlation between schlemm’s canal dimensions and outflow facility［J］.Exp Eye Res,1996,62(1):101-109.
［38］　SWAIN D L,HO J,LAI J,GONG H.Shorter scleral spur in eyes with primary open-angle glaucoma［J］.Invest Ophthalmol Vis Sci,2015,56(3):1638-1648.
［39］　杨玉霞,刘杏,黄晶晶,钟毅敏,肖辉.原发性开角型青光眼小梁网组织早衰的初步研究［J］.中山大学学报（医学科学版）, 2014, 35(5):796-800.
YANG Y X,LIU X,HUANG J J,ZHONG Y M,XIAO H.Primary experimental study of senescence in trabecular meshwork of primary open angle glaucoma［J］.J Sun Yat-sen Univ(Med Sci),2014, 35(5):796-800.
［40］　TEKTAS O,LTJEN-DRECOLL E.Structural changes of the trabecular meshwork in different kinds of glaucoma［J］.Exp Eye Res,2009,88(4):769-775.
［41］　ALLINGHAM R R,DE KATER A W,ETHIER C R,ANDERSON P J,HERTZMARK E,EPSTEIN D L.The relationship between pore density and outflow facility in human eyes［J］.Invest Ophthalmol Vis Sci,1992,33(5):1661-1669.
［42］　JOHNSON M,CHAN D,READ A T,CHRISTENSEN C,SIT A,ETHIER C R.The pore density in the inner wall endothelium of Schlemm’s canal of glaucomatous eyes［J］.Invest Ophthalmol Vis Sci,2002,43(9):2950-2955.
［43］　LAST J A,PAN T,DING Y,REILLY C M,KELLER K,ACOTT T S,et al.Elastic modulus determination of normal and glaucomatous human trabecular meshwork［J］.Invest Ophthalmol Vis Sci,2011, 52(5):2147-2152.
［44］　CAMRAS L J,STAMER W D,EPSTEIN D,GONZALEZ P,YUAN F.Circumferential tensile stiffness of glaucomatous trabecular meshwork［J］.Invest Ophthalmol Vis Sci,2014,55(2):814-823.
［45］　VAHABIKASHI A,GELMAN A,DONG B,GONG L,CHA E,SCHIMMEL M,et al.Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes［J］.Proc Natl Acad Sci U S A,2019,116(52):26555-26563.
［46］　OVERBY D R,ZHOU E H,VARGAS-PINTO R,PEDRIGI R M,FUCHSHOFER R,BRAAKMAN S T,et al.Altered mechanobiology of Schlemm’s canal endothelial cells in glaucoma［J］.Proc Natl Acad Sci U S A,2014,111(38):13876-13881.
［47］　CHOI W,LEE M W,KANG H G,LEE H S,BAE H W,KIM C Y,et al.Comparison of the trabecular meshwork length between open and closed angle with evaluation of the scleral spur location［J］.Sci Rep,2019,9(1):6857.
［48］　CHEUNG C Y,ZHENG C,HO C L,TUN T A,KUMAR R S,SAYYAD F E,et al.Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the schwalbe line as the landmark［J］.Br J Ophthalmol,2011,95(7):955-959.
［49］　HONG J,YANG Y,WEI A,DENG S X,KONG X,CHEN J,et al.Schlemm’s canal expands after trabeculectomy in patients with primary angle-closure glaucoma［J］.Invest Ophthalmol Vis Sci,2014,55(9):5637-5642.
［50］　MANSOORI T,REDDY A A,TUMATI N C,BALAKRISHNA N.Assessment of schlemm’s canal in acute primary angle closure:an anterior segment optical coherence tomography study［J］.Int Ophthalmol,2019,39(10):2171-2177.
［51］　MATOS A G,ASRANI S G,PAULA J S.Feasibility of laser trabeculoplasty in angle closure glaucoma:a review of favourable histopathological findings in narrow angles［J］.Clin Exp Ophthalmol,2017,45(6):632-639.
［52］　SIHOTA R,GOYAL A,KAUR J,GUPTA V,NAG T C.Scanning electron microscopy of the trabecular meshwork:understanding the pathogenesis of primary angle closure glaucoma［J］.Indian J Ophthalmol,2012,60(3):183-188.
［53］　HAMANAKA T,KASAHARA K,TAKEMURA T.Histopathology of the trabecular meshwork and schlemm’s canal in primary angle-closure glaucoma［J］.Invest Ophthalmol Vis Sci,2011,52(12):8849-8861.
［54］　GUPTA V,SINGH A,PANDYA I,SOFI R,SEN S,SOMARAJAN B I,et al.Differences in outflow channels between two eyes of unilateral primary congenital glaucoma［J］.Acta Ophthalmol,2021,99(2):187-194.
［55］　SHI Y,HAN Y,XIN C,HU M,OATTS J,CAO K,et al.Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma:an in vivo high-frequency ultrasound biomicroscopy-based study［J］.PLoS One,2020,15(1):e227602.
［56］　TSUTSUI A,HAMANAKA T,MANABE K,KAIDZU S,KUMASAKA T,TANITO M.Histologic findings of trabecular meshwork and schlemm’s canal after microhook ab interno trabeculotomy［J］.J Glaucoma,2021,30(2):203-205.
［57］　LI G,LEE C,AGRAHARI V,WANG K,NAVARRO I,SHERWOOD J M,et al.In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model［J］.Proc Natl Acad Sci U S A,2019,116(5):1714-1722.
［58］　LI G,LEE C,READ A T,WANG K,HA J,KUHN M,et al.Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis［J］.Elife,2021,10:e60831.
［59］　RAZALI N,AGARWAL R,AGARWAL P,KAPITONOVA M Y,KANNAN KUTTY M,SMIRNOV A,et al.Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs［J］.Eur J Pharmacol,2015,749:73-80.
［60］　TAWARA A,TOU N,KUBOTA T,HARADA Y,YOKOTA K.Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma［J］.Graefes Arch Clin Exp Ophthalmol,2008,246(7):1021-1028.
［61］　赵静,张琦.糖皮质激素性青光眼小梁细胞超微结构的改变［J］.眼科学报,2010,25(2):119-124.
ZHAO J,ZHANG Q.Ultrastructural changes of the trabecular meshwork in glucocorticoid induced glaucoma［J］.Eye Sci,2010,25(2):119-124.
［62］　MCCARTNEY M D,CANTU-CROUCH D,CLARK A F.Freeze-fracture examination of cultured human trabecular meshwork cells:effect of dexamethasone［J］.Exp Eye Res,2006,82(6):994-1001.
［63］　OVERBY D R,BERTRAND J,TEKTAS O,BOUSSOMMIER-CALLEJA A,SCHICHT M,ETHIER C R,et al.Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice［J］.Invest Ophthalmol Vis Sci,2014,55(8):4922-4933.
［64］　JOHNSON D,GOTTANKA J,FLUGEL C,HOFFMANN F,FUTA R,LUTJEN-DRECOLL E.Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids［J］.Arch Ophthalmol,1997,115(3):375-383.
［65］　REN R,HUMPHREY A A,SWAIN D L,GONG H.Relationships between intraocular pressure,effective filtration area,and morphological changes in the trabecular meshwork of steroid-induced ocular hypertensive mouse eyes［J］.Int J Mol Sci,2022,23(2):854.
［66］　RAGHUNATHAN V K,MORGAN J T,PARK S A,WEBER D,PHINNEY B S,MURPHY C J,et al.Dexamethasone stiffens trabecular meshwork,trabecular meshwork cells,and matrix［J］.Invest Ophthalmol Vis Sci,2015,56(8):4447-4459.
［67］　WATANABE Y,HAMANAKA T,TAKEMURA T,MURAKAMI A.Involvement of platelet coagulation and inflammation in the endothelium of schlemm’s canal［J］.Invest Ophthalmol Vis Sci,2010,51(1):277-283.
［68］　YAN X,LI M,WANG J,ZHANG H,ZHOU X,CHEN Z.Morphology of the trabecular meshwork and schlemm’s canal in posner-schlossman syndrome［J］.Invest Ophthalmol Vis Sci,2022,63(1):1.
［69］　BANEKE A J,LIM K S,STANFORD M.The pathogenesis of raised intraocular pressure in uveitis［J］.Curr Eye Res,2016,41(2):137-149.
［70］　TEKTAS O,HEINZ C,HEILIGENHAUS A,HAMMER C M,LUETJEN-DRECOLL E.Morphological changes of trabeculectomy specimens in different kinds of uveitic glaucoma［J］.Curr Eye Res,2011,36(5):442-448.
［71］　YOSHIDA N,HISATOMI T,IKEDA Y,KOHNO R,MURAKAMI Y,IMAKI H,et al.Intravitreal bevacizumab treatment for neovascular glaucoma:histopathological analysis of trabeculectomy specimens［J］.Graefes Arch Clin Exp Ophthalmol,2011,249(10):1547-1552.
［72］　HASE K,KASE S,KANDA A,SHINMEI Y,NODA K,ISHIDA S.Expression of vascular endothelial growth factor-c in the trabecular meshwork of patients with neovascular glaucoma and primary open-angle glaucoma［J］.J Clin Med,2021,10(13):2977.
［73］　DANG Y,WAXMAN S,WANG C,SHAH P,LOEWEN R T,LOEWEN N A.Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma［J］.F1000Res,2018,7:174.
［74］　GOTTANKA J,JOHNSON D H,GREHN F,LTJEN-DRECOLL E.Histologic findings in pigment dispersion syndrome and pigmentary glaucoma［J］.J Glaucoma,2006,15(2):142-151.

相似文献/References:

[1]李翔 谢钊 郭红建 谢学军 路雪婧 王毅 王超.补肾活血中药对大鼠慢性高眼压模型外侧膝状体病理改变的影响[J].眼科新进展,2012,32(1):000.
[2]范虹 刘五存 蔡鸿英 赵堪兴.改良二极管激光睫状体光凝术治疗中晚期青光眼[J].眼科新进展,2012,32(4):000.
[3]王建萍 赵燕麟 马勇 朱涛 程燕 车选义 赵桂娥 王柯.噻吗洛尔和布林佐胺联合曲伏前列素治疗原发性开角型青光眼与高眼压患者的临床研究[J].眼科新进展,2012,32(5):000.
[4]彭坤 靳隽 杨玉新 许银霞 王保君 闫义涛 杨华.长期联合应用噻吗洛尔对结膜组织炎性标记物ICAM-1和HLA-DR表达的影响[J].眼科新进展,2012,32(6):000.
[5]马恩普 赵小钊 董良 刘苏冰 曾照年.Healaflow在青光眼小梁切除术中的应用[J].眼科新进展,2012,32(6):000.
[6]王勇 叶应嘉 鲍先议 周龑丽 许荣 彭婷婷 曾志富.同轴微小切口超声乳化吸出术在青光眼滤过术后白内障摘出术中的应用[J].眼科新进展,2012,32(7):000.
[7]李翔 马世勇 李娟 王毅.补肾活血中药对大鼠慢性高眼压模型视神经病理改变的影响[J].眼科新进展,2013,33(2):000.
[8]白东娥 刘伟 季建.抗青光眼药物对青光眼患者泪液胰岛素水平的影响及其与眼表改变的关系[J].眼科新进展,2013,33(6):000.
[9]马英慧 张铁民 齐建平.原发性开角型青光眼与慢性原发性闭角型青光眼视网膜神经纤维层厚度与视野缺损的关系[J].眼科新进展,2013,33(7):000.
[10]张海涛 杨玉新 毛永 丁晓丽 秦海霞 梁长华 郭英昌.青光眼与非炎症性缺血型视神经病变的傅立叶OCT扫描视神经形态学对比[J].眼科新进展,2013,33(8):000.
[11]张青林,张旭.干细胞治疗青光眼的研究进展[J].眼科新进展,2017,37(9):886.[doi:10.13389/j.cnki.rao.2017.0225]
　ZHANG Qing-Lin,ZHANG Xu.Stem cells for the treatment of glaucoma[J].Recent Advances in Ophthalmology,2017,37(11):886.[doi:10.13389/j.cnki.rao.2017.0225]

备注/Memo

备注/Memo:
国家自然科学基金项目（编号：82201177）；国家重点研发计划项目（编号：2020YFC2008200）；浙江省“尖兵”“领雁”研发攻关计划项目（编号：2022C03112）；浙江省万人计划科技创新领军人才项目（编号：2021R52012）；浙江省高校领军人才培养计划项目（编号：2020099）；浙江省医药卫生项目（编号：2023KY914）
更新日期/Last Update: 2023-11-05