[1]杨娟,杜磊,曾思雨,等.不同浓度的人工泪液对合并中重度干眼的白内障患者角膜曲率测量和人工晶状体度数计算的影响[J].眼科新进展,2023,43(8):623-626.[doi:10.13389/j.cnki.rao.2023.0126]
　YANG Juan,DU Lei,ZENG Siyu,et al.Influence of different concentrations of artificial tears on keratometric measurement and intraocular lens power calculation in cataract patients with moderate to severe dry eyes[J].Recent Advances in Ophthalmology,2023,43(8):623-626.[doi:10.13389/j.cnki.rao.2023.0126]
点击复制

不同浓度的人工泪液对合并中重度干眼的白内障患者角膜曲率测量和人工晶状体度数计算的影响/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年8期
页码:
623-626
栏目:
应用研究
出版日期:
2023-08-05

文章信息/Info

Title:
Influence of different concentrations of artificial tears on keratometric measurement and intraocular lens power calculation in cataract patients with moderate to severe dry eyes
作者:
杨娟; 杜磊; 曾思雨; 邢怡桥
213001 江苏省常州市，常州市第三人民医院眼科（杨娟）；430060 湖北省武汉市，武汉大学人民医院眼科中心（杜磊，曾思雨，邢怡桥）
Author(s):
YANG Juan1; DU Lei2; ZENG Siyu2; XING Yiqiao2
1.Department of Ophthalmology,the Third People’s Hospital of Changzhou,Changzhou 213001,Jiangsu Province,China
2.Department of Ophthalmology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China
关键词:
干眼; 人工泪液; 角膜曲率; 人工晶状体度数; 白内障
Keywords:
dry eye;  artificial tear;  corneal curvature;  intraocular lens power;  cataract
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2023.0126
文献标志码:
A
摘要:
目的　探讨不同浓度的人工泪液对合并中重度干眼的白内障患者角膜曲率测量和人工晶状体度数计算的影响。
方法　本研究共纳入合并中重度干眼的白内障患者80例80眼，依据患者所用人工泪液玻璃酸钠滴眼液的浓度将患者分为低浓度组和高浓度组各40例40眼。低浓度组患者采用1 g·L-1玻璃酸钠滴眼液滴眼；高浓度组患者采用3 g·L-1玻璃酸钠滴眼液滴眼。于用药前和用药后1、5、15 min测量受试眼平坦轴角膜曲率（K1），计算患者所需人工晶状体度数，对比其变化情况。
结果　用药后1 min和5 min，低浓度组受试眼K1均较用药前减小，差异均有统计学意义（均为P<0.05）；用药后15 min，低浓度组受试眼K1与用药前比较，差异无统计学意义（P=0.556）。高浓度组受试眼用药前后K1变化情况与低浓度组相似。用药前两组受试眼K1差异无统计学意义（P>0.05）。用药后1 min，低浓度组受试眼K1较高浓度组升高（P<0.05）。用药后1 min和5 min，低浓度组受试眼人工晶状体度数均较用药前增大，差异均有统计学意义（均为P<0.05）；用药后15 min，低浓度组受试眼人工晶状体度数与用药前比较，差异无统计学意义（P=0.160）。高浓度组受试眼人工晶状体度数变化情况与低浓度组相似。用药后1、5、15 min，两组受试眼人工晶状体度数差异均无统计学意义（均为P>0.05）。
结论　合并中重度干眼的白内障患者使用人工泪液短时间内会显著减小患眼K1，增大人工晶状体度数；建议使用人工泪液后应超过15 min再进行白内障术前生物测量。
Abstract:
Objective　To investigate the effects of different concentrations of artificial tears on keratometric measurement and intraocular lens (IOL) power calculation of patients with cataracts combined with moderate to severe dry eyes.
Methods　A total of 80 cataract patients (80 eyes) with moderate to severe dry eyes were enrolled. According to the concentration of sodium hyaluronate eye drops used, patients were randomly divided into the low-concentration group (40 eyes) and the high-concentration group (40 eyes). Patients in the low-concentration group were given 1 g·L-1 sodium hyaluronate eye drops, while those in the high-concentration group were administered 3 g·L-1 sodium hyaluronate eye drops. The corneal curvature in the flat axis (K1) was measured, and the IOL power required was calculated before, 1, 5, and 15 minutes after the administration. The changes were compared.
Results　In the low-concentration group, at 1 and 5 minutes after the administration, K1 was significantly lower than that before administration (both P<0.05); at 15 minutes after the administration, there was no significant difference in K1 compared with that before administration (P=0.556). The changes of K1 in the high-concentration group were similar to those in the low-concentration group. There was no significant difference in K1 between the two groups before administration (P>0.05). At 1 minute after administration, K1 of the low-concentration group was significantly higher than that of the high-concentration group (P<0.05). In the low-concentration group, at 1 and 5 minutes after administration, the IOL power was significantly higher than that before administration (both P<0.05); at 15 minutes after administration, there was no significant difference in IOL power compared with that before administration (P=0.160). The changes of IOL power in the high-concentration group were similar to those in the low-concentration group. At 1, 5 and 15 minutes after administration, there was no significant difference in IOL power between the two groups (all P>0.05).
Conclusion　The use of artificial tears on cataract patients with moderate to severe dry eyes can significantly decrease the K1 and increase the IOL power in a short time. It is recommended to perform the preoperative bio-measurement more than 15 minutes after the administration of artificial tears.

参考文献/References:

［1］　BROGAN K,DIAPER C J M,ROTCHFORD A P.Cataract surgery refractive outcomes：representative standards in a National Health Service setting［J］.Br J Ophthalmol,2019,103(4)：539-543.
［2］　MNESTAM E.Long-term outcomes of cataract surgery：15-year results of a prospective study［J］.J Cataract Refract Surg,2016,42(1)：19-26.
［3］　EPITROPOULOS A T,MATOSSIAN C,BERDY G J,MALHOTRA R P,POTVIN R.Effect of tear osmolarity on repeatability of keratometry for cataract surgery planning［J］.J Cataract Refract Surg,2015,41(8)：1672-1677.
［4］　KOBASHI H,KAMIYA K,YANOME K,IGARASHI A,SHIMIZU K.Longitudinal assessment of optical quality and intraocular scattering using the double-pass instrument in normal eyes and eyes with short tear breakup time［J］.PLoS One,2013,8(12)：e82427.
［5］　STAPLETON F,ALVES M,BUNYA V Y,JALBERT I,LEKHANONT K,MALET F,et al.TFOS DEWS II epidemiology report［J］.Ocul Surf,2017,15(3)：334-365.
［6］　INOMATA T,NAKAMURA M,IWAGAMI M,SHIANG T,YOSHIMURA Y,FUJIMOTO K,et al.Risk factors for severe dry eye disease：crowdsourced research using Dry Eye Rhythm［J］.Ophthalmology,2019,126(5)：766-768.
［7］　SHEARD R.Optimising biometry for best outcomes in cataract surgery［J］.Eye,2014,28(2)：118-125.
［8］　KOH S.Irregular astigmatism and higher-order aberrations in eyes with dry eye disease［J］.Invest Ophthalmol Vis Sci,2018,59(14)：DES36-DES40.
［9］　MELLES R B,HOLLADAY J T,CHANG W J.Accuracy of intraocular lens calculation formulas［J］.Ophthalmology,2018,125(2)：169-178.
［10］　CHUANG J,SHIH K C,CHAN T C,WAN K H,JHANJI V,TONG L.Preoperative optimization of ocular surface disease before cataract surgery［J］.J Cataract Refract Surg,2017,43(12)：1596-1607.
［11］　SRIVANNABOON S,CHIRAPAPAISAN C,CHONPIMAI P,LOKET S.Clinical comparison of a new swept-source optical coherence tomography-based optical biometer and a time-domain optical coherence tomography-based optical biometer［J］.J Cataract Refract Surg,2015,41(10)：2224-2232.
［12］　AKMAN A,ASENA L,GNGR S G.Evaluation and comparison of the new swept source OCT-based IOLMaster 700 with the IOLMaster 500［J］.Br J Ophthalmol,2016,100(9)：1201-1205.
［13］　LU N,LIN F,HUANG Z,HE Q,HAN W.Changes of corneal wavefront aberrations in dry eye patients after treatment with artificial lubricant drops［J］.J Ophthalmol,2016,2016：1342056.
［14］　MONTS-MIC R,CLIZ A,ALI J L.Changes in ocular aberrations after instillation of artificial tears in dry-eye patients［J］.J Cataract Refract Surg,2004,30(8)：1649-1652.
［15］　KOH S,MAEDA N,IKEDA C,TAKAI Y,FUJIMOTO H,OIE Y,et al.Effect of instillation of eyedrops for dry eye on optical quality［J］.Invest Ophthalmol Vis Sci,2013,54(7)：4927-4933.
［16］　RGGLA V,LEYDOLT C,SCHARTMLLER D,SCHWARZENBACHER L,MEYER E,ABELA-FORMANEK C,et al.Influence of artificial tears on keratometric measurements in cataract patients［J］.Am J Ophthalmol,2021,221：1-8.

相似文献/References:

[1]姜洋 李莹 王忠海 罗岩 金玉梅.小牛血去蛋白提取物眼用凝胶对LASIK 术后角膜修复及干眼的疗效观察[J].眼科新进展,2012,32(7):000.
[2]张向东 刘海凤 刁婷婷.复方王不留行片联合人工泪液治疗更年期女性眼干燥症的疗效观察[J].眼科新进展,2012,32(7):000.
[3]张磊 何彦津.无眼征Graves病患者的眼表损害[J].眼科新进展,2012,32(12):000.
[4]皮百木 穆红梅 张婉婷 郑娜 李娟.老年干眼患者眼表改变及其与睑板腺功能障碍的相关性[J].眼科新进展,2013,33(6):000.
[5]张宏 马俊旗 安晓 叶向彧.围绝经期干眼患者眼表CXCR3表达与性激素的相关性分析[J].眼科新进展,2013,33(9):000.
[6]叶芬 田农 施宇华 薛春燕 黄振平.糖尿病干眼患者的波前像差分析[J].眼科新进展,2012,32(4):000.
[7]魏瑞华 郝永娜 赵少贞.自身免疫相关性干眼动物模型的研究进展[J].眼科新进展,2012,32(7):000.
[8]黄洁 赵婕 徐红 陆豪 刘焰.针灸联合人工泪液治疗干眼症的疗效观察[J].眼科新进展,2012,32(9):000.
[9]魏瑞华 郝永娜 边领斋 李雪 粘红 赵少贞.Sjogren综合征相关性干眼发病机制的研究进展[J].眼科新进展,2013,33(3):000.
[10]毛祖红 王乐 邵毅 张广斌 叶向彧 陈乐磊 董诺.不同方位切口对角膜神经损伤及泪膜功能影响相关性研究[J].眼科新进展,2013,33(12):000.
[11]叶芬 王春红 陈银 施宇华 黄振平.人工泪液对糖尿病干眼患者泪河的影响[J].眼科新进展,2012,32(12):000.
[12]邱伟强 李学民 王薇 刘子源 张志红.泪点栓塞和人工泪液对干眼患者视功能和泪膜稳定性的影响[J].眼科新进展,2013,33(10):000.
[13]毛光兰,贾奎. 针灸联合人工泪液治疗对干眼症患者眼表功能的影响分析[J].眼科新进展,2015,35(6):582.[doi:10.13389/j.cnki.rao.2015.0158]
　MAO Guang-Lan,JIA Kui. Effects of acupuncture and artificial tears treatment on ocular surface function in patients with dry eye[J].Recent Advances in Ophthalmology,2015,35(8):582.[doi:10.13389/j.cnki.rao.2015.0158]

更新日期/Last Update: 2023-08-05