[1]王怀华,米东明,刘娜,等.COVID-19相关急性黄斑神经视网膜病变的眼底影像学特征[J].眼科新进展,2023,43(7):562-564.[doi:10.13389/j.cnki.rao.2023.0113]
　WANG Huaihua,MI Dongming,LIU Na,et al.Fundus imaging features of acute macular neuroretinopathy associated with COVID-19 infection[J].Recent Advances in Ophthalmology,2023,43(7):562-564.[doi:10.13389/j.cnki.rao.2023.0113]
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COVID-19相关急性黄斑神经视网膜病变的眼底影像学特征/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年7期
页码:
562-564
栏目:
应用研究
出版日期:
2023-07-05

文章信息/Info

Title:
Fundus imaging features of acute macular neuroretinopathy associated with COVID-19 infection
作者:
王怀华; 米东明; 刘娜; 刘延晶; 王少鹏
255000　山东省淄博市，淄博市中心医院眼科
Author(s):
WANG Huaihua; MI Dongming; LIU Na; LIU Yanjing; WANG Shaopeng
Department of Ophthalmology,Zibo Central Hospital,Zibo 255000,Shandong Province,China
关键词:
急性黄斑神经视网膜病变; 近红外眼底照相; 光学相干断层扫描; 光学相干断层扫描血管成像; 新型冠状病毒感染
Keywords:
acute macular neuroretinopathy;  near-infrared reflectance imaging;  optical coherence tomography;  optical coherence tomography angiography;  COVID-19 infection
分类号:
R774
DOI:
10.13389/j.cnki.rao.2023.0113
文献标志码:
A
摘要:
目的　分析新型冠状病毒感染（COVID-19）相关急性黄斑神经视网膜病变(AMN)患者的眼底影像学特征。
方法　回顾性研究。选取2022年12月20日至2023年1月3日于我院就诊的COVID-19相关AMN患者6例（12眼）作为研究对象；综合患者的眼底彩照、近红外眼底照相、荧光素眼底血管造影（FFA）、OCT和OCTA检查结果，分析COVID-19相关AMN患者的眼底影像学特征。
结果　6例患者感染COVID-19后均出现高热，发热后2～4（2.8±0.7）d出现单眼或双眼中心或旁中心暗点，或伴有视力下降。眼底彩照检查结果显示：眼底正常4眼，黄斑区色素紊乱呈楔形病灶1眼，黄斑区反光消失且局部变暗7眼。近红外眼底照相检查结果显示：所有患眼均表现为黄斑周边局灶性弱反射病灶，其中7眼弱反射病灶位于黄斑中心凹，5眼位于黄斑中心凹偏鼻侧。FFA检查结果显示：所有患眼视网膜未见异常荧光。OCT检查结果显示：所有患眼外核层及外丛状层出现点片状高反射病灶，局部椭圆体带缺损、连续性中断。OCTA检查结果显示：2眼出现视网膜深层毛细血管血流密度降低，enface OCT显示对应位置呈高反射。
结论　COVID-19相关AMN患者的眼底影像学特征表现为近红外眼底照相示患眼均表现为黄斑周边局灶性弱反射病灶；OCT检查示患眼外核层及外丛状层出现点片状高反射病灶，局部椭圆体带缺损、连续性中断；OCTA检查示患眼视网膜深层毛细血管血流密度降低。
Abstract:
Objective　To explore the fundus imaging features of acute macular neuroretinopathy (AMN) associated with COVID-19 infection.
Methods　Six patients (12 eyes) diagnosed as AMN associated with COVID-19 infection in our hospital from December 20,2022 to January 3,2023 were included in this retrospective study.Based on the results of fundus photography,near-infrared reflectance (NIR) imaging,fluorescein fundus angiography (FFA),optical coherence tomography (OCT),and optical coherence tomography angiography (OCTA),the fundus imaging features of AMN associated with COVID-19 infection were analyzed.
Results　These six patients developed a high fever after COVID-19 infection.Central/paracentral scotoma in one eye or both eyes appeared 2-4 (2.8±0.7) days after fever,or accompanied by vision loss.The fundus photography revealed that the fundus was normal in 4 eyes,the macular pigment disorder was a wedge-shaped lesion in 1 eye,and the macular reflection disappeared and locally darkened in 7 eyes.The NIR imaging demonstrated localized areas of hyporeflection in or around the macula,among which 7 lesions were in the macular fovea,and 5 lesions on the nasal side of the macular fovea.The FFA showed no abnormal fluorescence in the retina of all eyes.The OCT showed flake-like hyperreflective lesions in the outer nuclear layer and the outer plexiform layer,defect and discontinuity in local ellipsoid zones.The OCTA revealed decreased vessel density at the deep capillary plexus in 2 eyes.The enface OCT showed high reflection in the corresponding area.
Conclusion　The fundus imaging features of AMN associated with COVID-19 infection are summarized as follows: the NIR imaging demonstrates localized areas of hyporeflection around the macula; the OCT shows flake-like hyperreflective lesions in the outer nuclear layer and the outer plexiform layer,defect and discontinuity in local ellipsoid zones; the OCTA reveals decreased vessel density at the deep capillary plexus.

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相似文献/References:

[1]熊淑敏,饶杰,程琪,等.新型冠状病毒感染后急性黄斑神经视网膜病变的多模影像学特征[J].眼科新进展,2023,43(9):712.[doi:10.13389/j.cnki.rao.2023.0143]
　XIONG Shumin,RAO Jie,CHENG Qi,et al.Multimodal imaging characteristics of acute macular neuroretinopathy after COVID-19 infection[J].Recent Advances in Ophthalmology,2023,43(7):712.[doi:10.13389/j.cnki.rao.2023.0143]

备注/Memo

备注/Memo:
山东省淄博市重点研发计划(公益类专项)(编号:2019gy010046）
更新日期/Last Update: 2023-07-05