[1]杨雪,张琪.干燥环境相关性干眼的发病机制研究进展[J].眼科新进展,2023,43(6):496-499.[doi:10.13389/j.cnki.rao.2023.0101]
　YANG Xue,ZHANG Qi.Advances in the pathogenesis of dry environment-associated dry eye[J].Recent Advances in Ophthalmology,2023,43(6):496-499.[doi:10.13389/j.cnki.rao.2023.0101]
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干燥环境相关性干眼的发病机制研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年6期
页码:
496-499
栏目:
文献综述
出版日期:
2023-06-05

文章信息/Info

Title:
Advances in the pathogenesis of dry environment-associated dry eye
作者:
杨雪; 张琪
400016　重庆市，重庆医科大附属第一医院眼科
Author(s):
YANG Xue; ZHANG Qi
Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China
关键词:
干眼; 发病机制; 干燥环境; 应激反应
Keywords:
dry eye;  pathogenesis;  dry environment;  stress response
分类号:
R777.34
DOI:
10.13389/j.cnki.rao.2023.0101
文献标志码:
A
摘要:
干燥环境相关性干眼是指由长期处于低湿度环境中引起的干眼，与生活环境密切相关。目前干燥环境相关性干眼的发病机制尚不完全明确。炎症是干眼发病机制的关键一环，暴露于干燥环境在干眼的炎症进程中起着重要的作用，主要表现为干燥应激对眼表各方面产生不利影响，促进炎症，进而引起干眼。本文将从干燥环境出发，从眼表免疫稳态失衡、泪膜稳定性下降、氧化应激、神经调控异常几个方面对干燥环境因素在眼表炎症中的作用进行综述，以期全面认识干燥环境对干眼发病的影响，重视干燥环境因素在干眼诊疗中的作用。
Abstract:
Dry environment-associated dry eye refers to dry eye caused by long-term exposure to a low-humidity environment, which is closely related to the living environment. However, the pathogenesis of dry environment-associated dry eye has yet to be clear now. Inflammation is a critical factor in the pathogenesis of dry eye, and exposure to a dry environment plays an important role in the inflammatory process of dry eye. Dry stress has many adverse effects on the eye surface, promotes inflammation, and then causes dry eye. This article reviews the role of dry environment factors in ocular surface inflammation from the aspects of ocular surface immune homeostasis imbalance, tear film stability decline, oxidative stress, and abnormal neural regulation, so as to fully understand the impact of dry environment on dry eye and pay attention to the role of dry environment factors in the diagnosis and treatment of dry eye.

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备注/Memo

备注/Memo:
国家自然科学基金面上项目（编号：82070935）
更新日期/Last Update: 2023-06-05