参考文献/References:
[1] CHEUNG N,MITCHELL P,WONG T Y.Diabetic retinopathy[J].Lancet,2010,376(9735):124-136.
[2] KOYA D,KING G L.Protein kinase C activation and the development of diabetic complications[J].Diabetes,1998,47(6):859-866.
[3] MIWA K,NAKAMURA J,HAMADA Y,NARUSE K,NAKASHIMA E,KATO K,et al.The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes[J].Diabetes Res Clin Pract,2003,60(1):1-9.
[4] DU X L,EDELSTEIN D,ROSSETTI L,FANTUS I G,GOLDBERG H,ZIYADEH F,et al.Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation[J].Proc Natl Acad Sci USA,2000,97(22):12222-12226.
[5] HAMMES H P.Diabetic retinopathy:hyperglycaemia,oxidative stress and beyond[J].Diabetologia,2018,61(1):29-38.
[6] DAMMAK A,HUETE-TORAL F,CARPENA-TORRES C,MARTIN-GIL A,PASTRANA C,CARRACEDO G.From oxidative stress to inflammation in the posterior ocular diseases:diagnosis and treatment[J].Pharmaceutics,2021,13(9):1376.
[7] KANG Q,YANG C.Oxidative stress and diabetic retinopathy:molecular mechanisms,pathogenetic role and therapeutic implications[J].Redox Biol,2020,37:101799.
[8] MILLER D J,CASCIO M A,ROSCA M G.Diabetic retinopathy:the role of mitochondria in the neural retina and microvascular disease[J].Antioxidants (Basel),2020,9(10):905.
[9] POPRAC P,JOMOVA K,SIMUNKOVA M,KOLLAR V,RHODES C J,VALKO M.Targeting free radicals in oxidative stress-related human diseases[J].Trends Pharmacol Sci,2017,38(7):592-607.
[10] SIES H,BERNDT C,JONES D P.Oxidative stress[J].Annu Rev Biochem,2017,86:715-748.
[11] BROWNLEE M.The pathobiology of diabetic complications:a unifying mechanism[J].Diabetes,2005,54(6):1615-1625.
[12] ESHAQ R S,WRIGHT W S,HARRIS N R.Oxygen delivery,consumption,and conversion to reactive oxygen species in experimental models of diabetic retinopathy[J].Redox Biol,2014,2:661-666.
[13] DU Y,VEENSTRA A,PALCZEWSKI K,KERN T S.Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina[J].Proc Natl Acad Sci USA,2013,110(41):16586-16591.
[14] PAL S,RAO G N,PAL A.High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells[J].Life Sci,2020,256:117914.
[15] HAMADA Y,ARAKI N,KOH N,NAKAMURA J,HORIUCHI S,HOTTA N.Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway[J].Biochem Biophys Res Commun,1996,228(2):539-543.
[16] DAGHER Z,PARK Y S,ASNAGHI V,HOEHN T,GERHARDINGER C,LORENZI M.Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy[J].Diabetes,2004,53(9):2404-2411.
[17] GLOMB M A,MONNIER V M.Mechanism of protein modification by glyoxal and glycolaldehyde,reactive intermediates of the Maillard reaction[J].J Biol Chem,1995,270(17):10017-10026.
[18] YAMAGISHI S,NAKAMURA,MATSUI T,INAGAKI Y,TAKENAKA K,JINNOUCHI Y,et al.Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression[J].J Biol Chem,2006,281(29):20213-20220.
[19] YAMAGISHI S,MATSUI T.Advanced glycation end products (AGEs),oxidative stress and diabetic retinopathy[J].Curr Pharm Biotechnol,2011,12(3):362-368.
[20] SENA C M,MATAFOME P,CRISOSTOMO J,RODRIGUES L,FERNANDES R,PEREIRA P,et al.Methylglyoxal promotes oxidative stress and endothelial dysfunction[J].Pharmacol Res,2012,65(5):497-506.
[21] WANG N,WANG L,ZHANG C,TAN H Y,ZHANG Y,FENG Y.Berberine suppresses advanced glycation end products-associated diabetic retinopathy in hyperglycemic mice[J].Clin Transl Med,2021,11(11):e569.
[22] NAGY T,FISI V,FRANK D,KATAI E,NAGY Z,MISETA A.Hyperglycemia-induced aberrant cell proliferation; a metabolic challenge mediated by protein O-GlcNAc modification[J].Cells,2019,8(9):999.
[23] HART G W,HOUSLEY M P,SLAWSON C.Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins[J].Nature,2007,446(7139):1017-1022.
[24] DU X,MATSUMURA T,EDELSTEIN D,ROSSETTI L,ZSENGELLER Z,SZABO C,et al.Inhibition of GAPDH activity by poly (ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells[J].J Clin Invest,2003,112(7):1049-1057.
[25] GUREL Z,SHEIBANI N.O-linked beta-N-acetylglucosamine (O-GlcNAc) modification:a new pathway to decode pathogenesis of diabetic retinopathy[J].Clin Sci (Lond),2018,132(2):185-198.
[26] GERALDES P,KING G L.Activation of protein kinase C isoforms and its impact on diabetic complications[J].Circ Res,2010,106(8):1319-1331.
[27] WANG Q J.PKD at the crossroads of DAG and PKC signaling[J].Trends Pharmacol Sci,2006,27(6):317-323.
[28] DAS EVCIMEN N,KING G L.The role of protein kinase C activation and the vascular complications of diabetes[J].Pharmacol Res,2007,55(6):498-510.
[29] JIANG Y,ZHANG Q,STEINLE J J.Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina[J].Growth Factors,2015,33(3):192-199.
[30] VOLPE C M O,VILLAR-DELFINO P H,DOS ANJOS P M F,NOGUEIRA-MACHADO J A.Cellular death,reactive oxygen species (ROS) and diabetic complications[J].Cell Death Dis,2018,9(2):119.
[31] SENANAYAKE P,DRAZBA J,SHADRACH K,MILSTED A,RUNGGER-BRANDLE E,NISHIYAMA K,et al.Angiotensin II and its receptor subtypes in the human retina[J].Invest Ophthalmol Vis Sci,2007,48(7):3301-3311.
[32] OLA M S,ALHOMIDA A S,FERRARIO C M,AHMAD S.Role of tissue renin-angiotensin system and the Chymase/angiotensin-(1-12) axis in the pathogenesis of diabetic retinopathy[J].Curr Med Chem,2017,24(28):3104-3114.
[33] BEHI T,KOTWANI A.Potential of angiotensin II receptor blockers in the treatment of diabetic retinopathy[J].Life Sci,2017,176:1-9.
[34] PARK S W,YUN J H,KIM J H,KIM K W,CHO C H,KIM J H.Angiopoietin 2 induces pericyte apoptosis via alpha3beta1 integrin signaling in diabetic retinopathy[J].Diabetes,2014,63(9):3057-3068.
[35] MORI F,HIKICHI T,NAGAOKA T,TAKAHASHI J,KITAYA N,YOSHIDA A.Inhibitory effect of losartan,an AT1 angiotensin II receptor antagonist,on increased leucocyte entrapment in retinal microcirculation of diabetic rats[J].Br J Ophthalmol,2002,86(10):1172-1174.
[36] VUJOSEVIC S,MURACA A,ALKABES M,VILLANI E,CAVARZERAN F,ROSSETTI L,et al.Early microvascular and neural changes in patients with type 1 and type 2 diabetes mellitus without clinical signs of diabetic retinopathy[J].Retina,2019,39(3):435-445.
[37] LI Z,WEN X,ZENG P,LIAO Y,FAN S,ZHANG Y,et al.Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography[J].Acta Diabetol,2019,56(5):531-539.
[38] DOW C,MANCINI F,RAJAOBELINA K,BOUTRON-RUAULT M C,BALKSU B,BONNET F,et al.Diet and risk of diabetic retinopathy:a systematic review[J].Eur J Epidemiol,2018,33(2):141-156.
[39] GHADIRI SOUFI F,ARBABI-AVAL E,REZAEI KANAVI M,AHMADIEH H.Anti-inflammatory properties of resveratrol in the retinas of type 2 diabetic rats[J].Clin Exp Pharmacol Physiol,2015,42(1):63-68.
[40] YANG F,YU J,KE F,LAN M,LI D,TAN K,et al.Curcumin alleviates diabetic retinopathy in experimental diabetic rats[J].Ophthalmic Res,2018,60(1):43-54.
[41] NEELAM K,GOENADI C J,LUN K,YIP C C,AU EONG K G.Putative protective role of lutein and zeaxanthin in diabetic retinopathy[J].Br J Ophthalmol,2017,101(5):551-558.
[42] ROBLES-RIVERA R R,CASTELLANOS-GONZALEZ J A,OLVERA-MONTANO C,FLOREA-MARTIN R A,LOPZ-CONTRERAS A K,AREVALO-SIMENTAL D E,et al.Adjuvant therapies in diabetic retinopathy as an early approach to delay its progression:the importance of oxidative stress and inflammation[J].Oxid Med Cell Longev,2020,2020:3096470.
[43] VALLE M S,RUSSO C,MALAGUARNERA L.Protective role of vitamin D against oxidative stress in diabetic retinopathy[J].Diabetes Metab Res Rev,2021,37(8):e3447.
[44] NAKAI K,FUJII H,KONO K,GOTO S,KITAZAWA R,KITAZAWA S,et al.Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats[J].Am J Hypertens,2014,27(4):586-595.
[45] JIANG J,CHE X,QIAN Y,LU S,WANG Z.Myricitrin exerts protective effect on retina in diabetic retinopathy via modulating oxidative stress expression of VEGF and apoptosis in experimental rats:a docking confirmation study[J].Mol Cell Toxicol,2022,18:149-158.
[46] MEI X,ZHANG T,OUYANG H,LU B,WANG Z,JI L.Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy[J].Biochem Pharmacol,2019,159:82-95.
[47] WU S,NING Y,ZHAO Y,SUN W,THORIMBERT S,DECHOUX L,SOLLOGOUB M,ZHANG Y.Research progress of natural product gentiopicroside-a secoiridoid compound[J].Mini Rev Med Chem,2017,17(1):62-77.
[48] ZHANG X,SHI E,YANG L,FU W,ZHOU,X.Gentiopicroside attenuates diabetic retinopathy by inhibiting inflammation,oxidative stress,and NF-κB activation in rat model[J].Eur J Inflamm,2019,17(4):205873921984783.