[1]董敬红,薛嘉睿,张荣荣,等.病理性近视眼影像学生物标志物的研究现状[J].眼科新进展,2022,42(5):413-416.[doi:10.13389/j.cnki.rao.2022.0084]
　DONG Jinghong,XUE Jiarui,ZHANG Rongrong,et al.Update of imaging biomarkers of pathological myopia[J].Recent Advances in Ophthalmology,2022,42(5):413-416.[doi:10.13389/j.cnki.rao.2022.0084]
点击复制

病理性近视眼影像学生物标志物的研究现状/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年5期
页码:
413-416
栏目:
文献综述
出版日期:
2022-05-05

文章信息/Info

Title:
Update of imaging biomarkers of pathological myopia
作者:
董敬红; 薛嘉睿; 张荣荣; 吴昌凡
241001　安徽省芜湖市，皖南医学院附属第一医院弋矶山医院眼科
Author(s):
DONG Jinghong; XUE Jiarui; ZHANG Rongrong; WU Changfan
Department of Opthalmology,Yijishan Hospital of Wannan Medical University,Wuhu 241001,Anhui Province,China
关键词:
病理性近视; 影像学; 生物标志物
Keywords:
pathological myopia;  imaging;  biomarker
分类号:
R778.1
DOI:
10.13389/j.cnki.rao.2022.0084
文献标志码:
A
摘要:
高度近视和病理性近视的患病率正逐年增加，会造成严重的视力损害和社会危害。然而对高度近视和病理性近视的早期诊断、进展预判和治疗效果的评估等问题尚未解决。近年来，影像学技术的不断发展以及多模态成像的应用为病理性近视的诊断、疾病进展的监测及治疗效果的评估提供了有力的依据，尤其部分特异性影像学生物标志物的发现更有助于病理性近视的早期诊治和对其相关机制的认识。因此，本文就眼底照相、光学相干断层扫描和光学相干断层扫描血管造影中的病理性近视影像学生物标志物进行综述。
Abstract:
The prevalence of high myopia and pathological myopia is increasing year by year, causing serious visual impairment and social harm. However, the problems concerning early diagnosis, progress prediction, and therapeutic effect assessment of high myopia and pathological myopia have not been solved. In recent years, the continuous development of imaging technology and the application of multimodal imaging have provided a powerful basis for the diagnosis of pathological myopia, the monitoring of disease progression, and the evaluation of therapeutic effect. In particular, the discovery of some specific imaging biomarkers facilitates the early diagnosis and treatment of pathological myopia and the understanding of related mechanisms. This paper reviews the imaging biomarkers of pathological myopia found in fundus photography, optical coherence tomography, and optical coherence tomography angiography.

参考文献/References:

［1］　ZOU M,WANG S,CHEN A,LIU Z,YOUNG C A,ZHANG Y,et al.Prevalence of myopic macular degeneration worldwide:a systematic review and meta-analysis［J］.Br J Ophthalmol,2020，104（12）:1748-1754.
［2］　HAGEN L A,GJELLE J V B,ARNEGARD S,PEDERSEN H R,GILSON S J,BARAAS R C.Prevalence and possible factors of myopia in norwegian adolescents［J］.Sci Rep,2018,81:13479.
［3］　WONG T Y,FERREIRA A,HUGHES R,CARTER G,MITCHELL P.Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization:an evidence-based systematic review［J］.Am J Ophthalmol,2014,1571:9-25.
［4］　YOSHIHARA N,YAMASHITA T,OHNO-MATSUI K,SAKAMOTO T.Objective analyses of tessellated fundi and significant correlation between degree of tessellation and choroidal thickness in healthy eyes［J］.PLoS One,2014,97:e103586.
［5］　JAGADEESH D,PHILIP K,NADUVILATH T J,FEDTKE C,JONG M,ZOU H,et al.Tessellated fundus appearance and its association with myopic refractive error［J］.Clin Exp Optom,2019,1024:378-384.
［6］　TERASAKI H,YAMASHITA T,YOSHIHARA N,KII Y,TANAKA M,NAKAO K,et al.Location of tessellations in ocular fundus and their associations with optic disc tilt,optic disc area,and axial length in young healthy eyes［J］.PLoS One,2016,116:e0156842.
［7］　YOKOI T,JONAS J B,SHIMADA N,NAGAOKA N,MORIYAMA M,YOSHIDA T,et al.Peripapillary diffuse chorioretinal atrophy in children as a sign of eventual pathologic myopia in adults［J］.Ophthalmology,2016,1238:1783-1787.
［8］　TOKORO T.Atlas of posterior fundus changes in pathologic myopia［M］.Tokyo:Springer,1998.
［9］　VERKICHARLA P K,OHNO-MATSUI K,SAW S M.Current and predicted demographics of high myopia and an update of its associated pathological changes［J］.Ophthalmic Physiol Opt,2015,355:465-475.
［10］　WANG Y,YE J,SHEN M,YAO A,XUE A,FAN Y,et al.Photoreceptor degeneration is correlated with the deterioration of macular retinal sensitivity in high myopia［J］.Invest Ophthalmol Vis Sci,2019,608:2800-2810.
［11］　DHAKAL R,VUPPARABOINA K K,VERKICHARLA P K.Anterior sclera undergoes thinning with increasing degree of myopia［J］.Invest Ophthalmol Vis Sci,2020,614:6.
［12］　WONG C W,PHUA V,LEE S Y,WONG T Y,CHEUNG C M.Is choroidal or scleral thickness related to myopic macular degeneration?［J］.Invest Ophthalmol Vis Sci,2017,582:907-913.
［13］　KUO A N,VERKICHARLA P K,MCNABB R P,CHEUNG C Y,HILAL S,FARSIU S,et al.Posterior eye shape measurement with retinal OCT compared to MRI［J］.Invest Ophthalmol Vis Sci,2016,579:OCT196-203.
［14］　KUO A N,MCNABB R P,CHIU S J,EL-DAIRI M A,FARSIU S,TOTH C A,et al.Correction of ocular shape in retinal optical coherence tomography and effect on current clinical measures［J］.Am J Ophthalmol,2013,1562:304-311.
［15］　BREHER K,OHLENDORF A,WAHL S.Myopia induces meridional growth asymmetry of the retina:a pilot study using wide-field swept-source OCT［J］.Sci Rep,2020,101:10886.
［16］　MINAMI S,ITO Y,UENO S,KATAOKA K,TAKEUCHI J,ITO H,et al.Analysis of macular curvature in normal eyes using swept-source optical coherence tomography［J］.Jpn J Ophthalmol,2020,642:180-186.
［17］　CAILLAUX V,GAUCHER D,GUALINO V,MASSIN P,TADAYONI R,GAUDRIC A.Morphologic characterization of dome-shaped macula in myopic eyes with serous macular detachment［J］.Am J Ophthalmol,2013,1565:958-967.
［18］　LIANG I C,SHIMADA N,TANAKA Y,NAGAOKA N,MORIYAMA M,YOSHIDA T,et al.Comparison of clinical features in highly myopic eyes with and without a dome-shaped macula［J］.Ophthalmology,2015,1228:1591-1600.
［19］　LEE G W,KIM J H,KANG S W,KIM J.Structural profile of dome-shaped macula in degenerative myopia and its association with macular disorders［J］.BMC Ophthalmol,2020,201:202.
［20］　WANG L,LIN B W,YIN X F,HUANG W L,WANG Y Z,PANG L.Visual acuity and size of choroidal neovascularization in highly myopic eyes with a dome-shaped macula［J］.J Ophthalmol,2020,2020:8852156.
［21］　HENAINE-BERRA A,ZAND-HADAS I M,FROMOW-GUERRA J,GARCIA-AGUIRRE G.Prevalence of macular anatomic abnormalities in high myopia［J］.Ophthalmic Surg Lasers Imaging Retina,2013,442:140-144.
［22］　CHENG C,TEO K,TAN C S,LEE S Y,LOH B K,WONG E,et al.Myopic retinoschisis in asians:structural features and determinants of visual acuity and prognostic factors for progression［J］.Retina,2016,364:717-726.
［23］　张立,张成成,叶应嘉,蒋海翔.双眼先天性黄斑视网膜劈裂症1例［J］.国际眼科杂志,2013,13(2):213.
ZHANG L,ZHANG C C,YE Y J,JIANG H X.A case study of congenital macular retinal cleavage in both eyes ［J］.Int Eye Sci,2013,13(2):213.
［24］　MIYATA M,OOTO S,HATA M,YAMASHIRO K,TAMURA H,AKAGI-KURASHIGE Y,et al.Detection of myopic choroidal neovascularization using optical coherence tomography angiography［J］.Am J Ophthalmol,2016,165:108-114.
［25］　BAGCHI A,SCHWARTZ R,HYKIN P,SIVAPRASAD S.Diagnostic algorithm utilising multimodal imaging including optical coherence tomography angiography for the detection of myopic choroidal neovascularisation［J］.Eye (Lond),2019,337:1111-1118.
［26］　LI S,SUN L,ZHAO X,HUANG S,LUO X,ZHANG A,et al.Assessing the activity of myopic choroidal neovascularization:comparison between optical coherence tomography angiography and dye angiography［J］.Retina,2020,409:1757-1764.
［27］　GIORNO P,IACONO P,SCARINCI F,DI RENZO A,VARANO M,PARRAVANO M.Microvasculature changes of myopic choroidal neovascularization and the predictive value of feeder vessel disappearance after ranibizumab treatment revealed using optical coherence tomography angiography［J］.Ophthalmologica,2020,2434:263-270.
［28］　OHNO-MATSUI K,YOSHIDA T,FUTAGAMI S,YASUZUMI K,SHIMADA N,KOJIMA A,et al.Patchy atrophy and lacquer cracks predispose to the development of choroidal neovascularisation in pathological myopia［J］.Br J Ophthalmol,2003,875:570-573.
［29］　SAYANAGI K,HARA C,FUKUSHIMA Y,SAKIMOTO S,KAWASAKI R,SATO S,et al.Flow pattern and perforating vessels in three different phases of myopic choroidal neovascularization seen by swept-source optical coherence tomography angiography［J］.Graefes Arch Clin Exp Ophthalmol,2021,259(9):2015-2024.
［30］　LI M,YANG Y,JIANG H,GREGORI G,ROISMAN L,ZHENG F,et al.Retinal microvascular network and microcirculation assessments in high myopia［J］.Am J Ophthalmol,2017,174:56-67.
［31］　SAYANAGI K,IKUNO Y,UEMATSU S,NISHIDA K.Features of the choriocapillaris in myopic maculopathy identified by optical coherence tomography angiography［J］.Br J Ophthalmol,2017,101(11):1524-1529.
［32］　AL-SHEIKH M,PHASUKKIJWATANA N,DOLZ-MARCO R,RAHIMI M,IAFE N A,FREUND K B,et al.Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes［J］.Invest Ophthalmol Vis Sci,2017,584:2063-2069.
［33］　WONG C W,TEO Y C K,TSAI S T A,TING S W D,YEO Y S I,WONG W K D,et al.Characterization of the choroidal vasculature in myopic maculopathy with optical coherence tomographic angiography［J］.Retina,2019,399:1742-1750.
［34］　MO J,DUAN A,CHAN S,WANG X,WEI W.Vascular flow density in pathological myopia:an optical coherence tomography angiography study［J］.BMJ Open,2017,72:e013571.
［35］　陈秋莹，贺江南，华怡红，樊莹，许迅.高度近视继发视盘周围脉络膜空腔视盘血流密度的变化［J］.国际眼科杂志,2017,17（7）:1307-1312.
CHEN Q Y,HE J N,HUA Y H,FAN Y,XU X.Peripapillary vessel density and the relevant factors in highly myopic eyes with peripapillary intrachoroidal cavitation［J］．Int Eye Sci,2017,17(7):1307-1312.
［36］　CHEN Q,HE J,HUA Y,FAN Y.Exploration of peripapillary vessel density in highly myopic eyes with peripapillary intrachoroidal cavitation and its relationship with ocular parameters using optical coherence tomography angiography［J］.Clin Exp Ophthalmol,2017,459:884-893.
［37］　COMUNE C,MONTORIO D,CENNAMO G.Optical coherence tomography angiography in myopic peripapillary intrachoroidal cavitation complicated by choroidal neovascularization［J］.Eur J Ophthalmol,2021,31(4):1920-1924.
［38］　ISHIDA T,JONAS J B,ISHII M,SHINOHARA K,IKEGAYA Y,OHNO-MATSUI K.Peripapillary arterial ring of Zinn-Haller in highly myopic eyes as detected by optical coherence tomography angiography［J］.Retina,2017,372:299-304.
［39］　郑志坤，黎铧，李娟娟．高度近视眼视盘旁Zinn-Haller动脉环荧光血管造影特征分析［J］.眼科新进展,2015,35(5):479-481.
ZHENG Z K,LI H,LI J J.Characteristic analysis of Zinn-Haller arterial ring by fundus fluorescein angiography in high myopia ［J］.Rec Adv Ophthalmol,2015,35(5):479-481.
［40］　COLLINS M J,BUEHREN T,ISKANDER D R.Retinal image quality,reading and myopia［J］.Vision Res,2006,461(2):196-215.
［41］　POPE J M,VERKICHARLA P K,SEPEHRBAND F,SUHEIMAT M,SCHMID K L,ATCHISON D A.Three-dimensional MRI study of the relationship between eye dimensions,retinal shape and myopia［J］.Biomed Opt Express,2017,85:2386-2395.
［42］　ZHANG W,LI Y,NGUYEN V P,DEROUIN K,XIA X,PAULUS Y M,et al.Ultralow energy photoacoustic microscopy for ocular imaging in vivo［J］.J Biomed Opt,2020,256:1-8.
［43］　XIE D,LI Q,GAO Q,SONG W,ZHANG H F,YUAN X.In vivo blind-deconvolution photoacoustic ophthalmoscopy with total variation regularization［J］.J Biophotonics,2018,119:e201700360.

相似文献/References:

[1]金昱 石安娜 刘维锋 石浔 王永波.频域OCT在光动力疗法治疗病理性近视脉络膜新生血管中的应用[J].眼科新进展,2012,32(10):000.
[2]黄志坚 宋艳萍 金中秋 丁琴 陈中山.光动力疗法联合玻璃体内注射Bevacizumab治疗病理性近视合并脉络膜新生血管[J].眼科新进展,2013,33(4):000.
[3]王晓霞 史志洁 林娜 刘晓瑞.光学相干断层扫描在病理性近视黄斑裂孔中的应用[J].眼科新进展,2013,33(9):000.
[4]陆秉文,吴星伟. Ranibizumab玻璃体内注射治疗病理性近视脉络膜新生血管研究进展[J].眼科新进展,2014,34(9):897.[doi:10.13389/j.cnki.rao.2014.0248]
[5]丁雯芝,邹俊.病理性近视脉络膜新生血管发病机制的研究进展[J].眼科新进展,2014,34(10):987.[doi:10.13389/j.cnki.rao.2014.0274]
[6]陈珊娜,郑丽梅,洪荣照,等. 饼式后巩膜加固术治疗未成年人病理性近视临床研究[J].眼科新进展,2015,35(4):351.[doi:10.13389/j.cnki.rao.2015.0094]
　CHEN Shan-Na,ZHENG Li-Mei,HONG Rong-Zhao,et al. Clinical observation of cake-type sclera reinforcement for pathological myopia in minor[J].Recent Advances in Ophthalmology,2015,35(5):351.[doi:10.13389/j.cnki.rao.2015.0094]
[7]田楠楠,亢泽峰,张庆.加减驻景方对病理性近视脉络膜新生血管动物模型血管内皮生长因子及色素上皮衍生因子表达的影响[J].眼科新进展,2015,35(10):906.[doi:10.13389/j.cnki.rao.2015.0247]
　TIAN Nan-Nan,KANG Ze-Feng,ZHANG Qing.Effects of modified Zhu Jing prescriptions on expression of VEGF and PEDF in pathologic myopia with choroidal neovascularization animal model[J].Recent Advances in Ophthalmology,2015,35(5):906.[doi:10.13389/j.cnki.rao.2015.0247]
[8]修立恒,李佳林,李常栋,等.玻璃体内注射雷珠单抗治疗病理性近视合并脉络膜新生血管疗效观察[J].眼科新进展,2015,35(11):1067.[doi:10.13389/j.cnki.rao.2015.0292]
　XIU Li-Heng,LI Jia-Lin,LI Chang-Dong,et al.Pathological myopia combined with choroidal neovascularization treated by intravitreal injection of ranibizumab[J].Recent Advances in Ophthalmology,2015,35(5):1067.[doi:10.13389/j.cnki.rao.2015.0292]
[9]刘李平,宋徽,冀垒兵,等.玻璃体内注射雷珠单抗治疗病理性近视黄斑部脉络膜新生血管[J].眼科新进展,2016,36(7):667.[doi:10.13389/j.cnki.rao.2016.0177]
　LIU Li-Ping,SONG Hui,JI Lei-Bing,et al.Intravitreal ranibizumab injections for pathologic myopia macular choroidal neovascularization[J].Recent Advances in Ophthalmology,2016,36(5):667.[doi:10.13389/j.cnki.rao.2016.0177]
[10]刘维锋,赵雁之,李春英,等.高度近视眼后巩膜形态、黄斑轮廓形态临床观察[J].眼科新进展,2017,37(12):1158.[doi:10.13389/j.cnki.rao.2017.0292]
　LIU Wei-Feng,ZHAO Yan-Zhi,LI Chun-Ying,et al.Shapes of posterior sclera and macular in high myopia[J].Recent Advances in Ophthalmology,2017,37(5):1158.[doi:10.13389/j.cnki.rao.2017.0292]

备注/Memo

备注/Memo:
安徽省卫生健康委科研项目资助（编号：AHWJ2021b120）
更新日期/Last Update: 2022-05-21