[1]屈如意,周梦贤,毕宏生,等.巨噬细胞极化在眼科疾病发生发展过程中的作用机制研究进展[J].眼科新进展,2022,42(3):239-243.[doi:10.13389/j.cnki.rao.2022.0049]
　QU Ruyi,ZHOU Mengxian,BI Hongsheng,et al.Research advances in the role of macrophage polarization in the occurrence and development of ophthalmic diseases[J].Recent Advances in Ophthalmology,2022,42(3):239-243.[doi:10.13389/j.cnki.rao.2022.0049]
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巨噬细胞极化在眼科疾病发生发展过程中的作用机制研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年3期
页码:
239-243
栏目:
文献综述
出版日期:
2022-03-05

文章信息/Info

Title:
Research advances in the role of macrophage polarization in the occurrence and development of ophthalmic diseases
作者:
屈如意; 周梦贤; 毕宏生; 郭大东
250014　山东省济南市，山东中医药大学［屈如意（2021级硕士研究生），周梦贤（2020级硕士研究生）］；250002　山东省济南市，山东省中西医结合眼病防治重点实验室，山东省眼病防治研究院（毕宏生，郭大东）
Author(s):
QU Ruyi1; ZHOU Mengxian1; BI Hongsheng2; GUO Dadong2
1.Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China
2.Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases；Shandong Academy of Eye Disease Prevention and Therapy，Jinan 250002，Shandong Province，China
关键词:
巨噬细胞极化; 年龄相关性黄斑变性; 自身免疫性葡萄膜炎; 视网膜病变; 干燥综合征; 角膜炎
Keywords:
macrophage polarization;  age-related macular degeneration;  autoimmune uveitis;  retinopathy;  Sjgren’s syndrome;  ceratitis
分类号:
R771
DOI:
10.13389/j.cnki.rao.2022.0049
文献标志码:
A
摘要:
巨噬细胞是单核吞噬细胞系统的主要细胞群，充当先天性免疫和适应性免疫的哨兵。在微环境信号作用下，巨噬细胞可被不同的激活物极化为不同功能的M1型、M2型巨噬细胞。巨噬细胞极化既可以发生在生理条件下，也可以发生在病理条件下，并贯穿疾病发生、发展以及转归的全过程。很多眼科疾病的病理过程都和巨噬细胞极化密切相关，巨噬细胞极化及炎症因子介导的免疫反应是眼病发生的重要机制。本文简要综述了巨噬细胞的不同极化表型以及调节巨噬细胞极化平衡为治疗靶点在年龄相关性黄斑变性、自身免疫性葡萄膜炎、视网膜病变、干燥综合征以及角膜炎等眼科疾病中发挥的作用。
Abstract:
Macrophages are the main cell group in the mononuclear phagocyte system. They serve as sentinels for innate immunity and adaptive immunity. Under the effect of microenvironment signals, macrophages can be polarized to M1 or M2 type macrophages with different functions by different activators. Macrophage polarization occurs not only under physiological conditions but also under pathological conditions throughout the entire process of disease occurrence, development, and prognosis. Many pathological processes of eye diseases are closely related to macrophage polarization. The immune response mediated by macrophage polarization and inflammatory cytokine is important in the pathogenesis of eye diseases. This article mainly reviews the different polarization phenotypes of macrophages and the role of regulating the macrophage polarization in the treatment of eye diseases such as age-related macular degeneration, autoimmune uveitis, diabetic retinopathy, Sjogren’s syndrome, and ceratitis.

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备注/Memo

备注/Memo:
山东省自然科学基金重点项目（编号：ZR2020KC024）;国家自然科学基金项目（编号：81873163）
更新日期/Last Update: 2022-03-05