参考文献/References:
[1] CHEN Y Y,WU T T,HO C Y,YEH T C,SUN G C,KUNG Y H,et al.Dapagliflozin prevents NOX- and SGLT2-dependent oxidative stress in lens cells exposed to fructose-induced diabetes mellitus[J].Int J Mol Sci,2019,20(18):4357.
[2] YANG J,ZHAO S,TIAN F.SP1-mediated lncRNA PVT1 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract via miR-214-3p/MMP2 axis[J].J Cell Mol Med,2020,24(1):554-561.
[3] DING W,CAO C,GAO Y,ZHOU X,LAI Y.Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a,27b,148a,298,and 451a levels [J].Xenobiotica,2020,50(11):1267-1274.
[4] KOPACZ A,KLOSKA D,FORMAN H J,JOZKOWICZ A,GROCHOT-PRZECZEK A.Beyond repression of Nrf2:an update on Keap1 [J].Free Radic Biol Med,2020,157:63-74.
[5] SONG X,LONG D.Nrf2 and ferroptosis:a new research direction for neurodegenerative diseases [J].Front Neurosci,2020,14:267.
[6] CUADRADO A,ROJO A I,WELLS G,HAYES J D,COUSIN S P,RUMSEY W L,et al.Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases [J].Nat Rev Drug Discov,2019,18(4):295-317.
[7] LIU X F,HAO J L,XIE T,MALIK T H,LU C B,LIU C,et al.Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress [J].Aging Cell,2017,16(5):934-942.
[8] CHITRA P S,CHAKI D,BOIROJU N K,MOKALLA T R,GADDE A K,AGRAHARAM S G,et al.Status of oxidative stress markers,advanced glycation index,and polyol pathway in age-related cataract subjects with and without diabetes [J].Exp Eye Res,2020,2020:108230.
[9] AHMAD A,AHSAN H.Biomarkers of inflammation and oxidative stress in ophthalmic disorders [J].J Immunoassay Immunochem,2020,41(3):257-271.
[10] BATLIWALA S,XAVIER C,LIU Y,WU H L,PANG I H.Involvement of Nrf2 in ocular diseases [J].Oxid Med Cell Longev,2017,2017:1703810.
[11] BOUCHER B J,RE NIROOMAND M,FOTOUHI A,IRANNEJAD N.Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized controlled trial [J].Diabetes Res Clin Pract,2019,148(1):1-9.
[12] URUNO A,YAGISHITA Y,YAMAMOTO M.The Keap1-Nrf2 system and diabetes mellitus [J].Arch Biochem Biophys,2015,566:76-84.
[13] WU H,JIA L.Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling[J].Biosci Rep,2019,39(11):20192501.
[14] ZUO H,WANG S,FENG J,LIU X.BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling[J].Biochimie,2019,165:100-107.
[15] YAN J,PANG Y,ZHUANG J,LIN H,ZHANG Q,HAN L,et al.Selenepezil,a selenium-containing compound,exerts neuroprotective effect via modulation of the Keap1-Nrf2-ARE pathway and attenuates Aβ-induced cognitive impairment in vivo[J].ACS Chem Neurosci,2019,10(6):2903-2914.
[16] ASHRAF O,NASR M,NEBSEN M,SAID A M A,SAMMOUR O.In vitro stabilization and in vivo improvement of ocular pharmacokinetics of the multi-therapeutic agent baicalin:delineating the most suitable vesicular systems[J].Int J Pharm,2018,539(1/2):83-94.
[17] ZHU D Q,WANG S S,LAWLESS J,HE J C,ZHENG Z G.Dose dependent dual effect of baicalin and herb huangqin extract on angiogenesis[J].PLoS One,2016,11: e0167125.
[18] LU X Y,HE W,YANG W L,LI J L,HAN W Q,LIU Q,et al.Dual effects of baicalin on osteoclast differentiation and bone resorption[J].J Cell Mol Med,2018,22:5029-5039.
[19] CHLEDZIK S,STRAWA J,MATUSZEK K,NAZARUK J.Pharmacological effects of scutellarin,an active component of genus scutellaria and erigeron:a systematic review[J].Am J Chin Med,2018,46(2):319-337.
[20] TU W,WANG H,LI S,LIU Q,SHA H.The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases[J].Aging Dis,2019,10(3):637-651.
[21] XU Z,WEI Y,GONG J,CHO H,PARK J K,SUNG E R,et al.NRF2 plays a protective role in diabetic retinopathy in mice[J].Diabetologia,2014,57(1):204-213.
[22] LI J,QIAO Z,HU W,ZHANG W,SHAH S W A,ISHFAQ M.Baicalin mitigated mycoplasma gallisepticum-induced structural damage and attenuated oxidative stress and apoptosis in chicken thymus through the Nrf2/HO-1 defence pathway[J].Vet Res,2019,50(1):83.
[23] YU H,CHEN B,REN Q.Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway[J].Artif Cells Nanomed Biotechnol,2019,47(1):3657-3663.
[24] MENG X,HU L,LI W.Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway[J].Naunyn Schmiedebergs Arch Pharmacol,2019,392(11):1421-1433.
[25] SHI J,WU G,ZOU X,JIANG K.Enteral baicalin,a flavone glycoside,reduces indicators of cardiac surgery-associated acute kidney injury in rats[J].Cardiorenal Med,2019,9(1):31-40.
[26] CHEN G,CHEN X,NIU C,HUANG X,AN N,SUN J,et al.Baicalin alleviates hyperglycemia-induced endothelial impairment 1 via Nrf2[J].J Endocrinol,2018,JOE-18-0457.
[27] FANG J,WANG H,ZHOU J,DAI W,ZHU Y,ZHOU Y,et al.Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway[J].Drug Des Devel Ther,2018,12:2497-2508.
[28] SHI L,HAO Z,ZHANG S,WEI M,LU B,WANG Z,et al.Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway:the involvement of ERK1/2 and PKC[J].Biochem Pharmacol,2018,150(1):9-23.