[1]余雯,余霈,吴梦凡,等.玻璃体替代物在玻璃体视网膜疾病中的应用研究进展[J].眼科新进展,2020,40(12):1193-1196.[doi:10.13389/j.cnki.rao.2020.0265]
　YU Wen,YU Pei,WU Mengfan,et al.Research progress of vitreous substitutes in vitreoretinopathy[J].Recent Advances in Ophthalmology,2020,40(12):1193-1196.[doi:10.13389/j.cnki.rao.2020.0265]
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玻璃体替代物在玻璃体视网膜疾病中的应用研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年12期
页码:
1193-1196
栏目:
文献综述
出版日期:
2020-12-05

文章信息/Info

Title:
Research progress of vitreous substitutes in vitreoretinopathy
文章编号:
1193
作者:
余雯; 余霈; 吴梦凡; 余震
315400　浙江省宁波市，余姚余邵眼科医院（余雯）；453003　河南省新乡市，新乡医学院基础医学院（余霈）；02115　美国马萨诸塞州波士顿哈佛医学院布莱根妇女医院整形外科（吴梦凡）；02114　美国马萨诸塞州波士顿哈佛医学院马萨诸塞州眼耳医院（余震）
Author(s):
YU Wen1; YU Pei2; WU Mengfan3; YU Zhen4
1.The Yuyao Yushao Eye Hospital，Ningbo 315400，Zhejiang Province，China
2.School of Basic Medical Sciences,Xinxiang Medical University，Xinxiang 453003,Henan Province,China
3.Division of Plastic Surgery,Department of Surgery,Brigham and Women’s Hospital and Harvard Medical School,Boston 02115,MA,USA
4.Angiogenesis Laboratory,Department of Ophthalmology,Massachusetts Eye and Ear Infirmary,Harvard Medical School,Boston 02114,MA,USA
关键词:
玻璃体替代物; 玻璃体视网膜疾病; 水凝胶
Keywords:
vitreous substitute;  vitreoretinopathy;  hydrogel
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2020.0265
文献标志码:
A
摘要:
玻璃体替代物是玻璃体-视网膜手术中用于治疗视网膜疾病（如复杂的视网膜脱离、黄斑裂孔、糖尿病视网膜病变的并发症以及后段眼外伤）的玻璃体内填塞剂。在玻璃体切除治疗视网膜脱离的手术中，术者需在玻璃体切除后在玻璃体内填充玻璃体替代物，以使脱离的视网膜重新附着。但目前临床上可用的玻璃体替代物仅能做到短期维持。尽管研究人员进行了多年的深入研究，但仍未找到理想的玻璃体替代物。本综述列举了临床上需要应用玻璃体替代物的眼部疾病，并从临床和科研两个角度总结了现有玻璃体替代物的临床应用和研究进展。其中，聚合物水凝胶由于其具有良好的生物相容性，并且和天然玻璃体具有相似的物理性质，被认为是人工玻璃体替代物的未来，尤其是热敏智能水凝胶，最有可能成为理想的玻璃体替代物。
Abstract:
Vitreous substitutes are vitreous cavity packers used in vitreoretinal surgery to treat retinal diseases (e.g., complex retinal detachment, macular hole, complications of diabetic retinopathy, and posterior ocular trauma). In vitrectomy to treat retinal detachment, the surgeon needs to fill the vitreous cavity in the vitreous cavity after vitrectomy to reattach the detached retina. However, currently available vitreous substitutes can only achieve short-term maintenance. Although the researchers have conducted in-depth research for many years, they have not yet found an ideal vitreous substitute. This review lists the eye diseases that require vitreous substitutes in clinical practice and summarizes the clinical use and research progress of existing vitreous substitutes from both clinical and scientific perspectives. Among them, polymer hydrogels are considered to be the future of artificial vitreous substitutes due to their good biocompatibility and similar physical properties to natural vitreous bodies. Especially thermo sensitive smart hydrogels are most likely to be an ideal vitreous substitute.

参考文献/References:

［1］　LARADJI A,SHUI Y B,KARAKOCAK B B,EVANS L,HAMILTON P,RAVI N.Bioinspired thermosensitive hydrogel as a vitreous substitute:synthesis,properties,and progress of animal studies［J］.Materials(Basel),2020,13(6):1337.
［2］　SU X,TAN M J,LI Z,WONG M,RAJAMANI L,LINGAM G,et al.Recent progress in using biomaterials as vitreous substitutes［J］.Biomacromolecules,2015,16(10):3093-3102.
［3］　YU Z,MA S,WU M,CUI H,WU R,CHEN S,et al.Self-assembling hydrogel loaded with 5-FU PLGA microspheres as a novel vitreous substitute for proliferative vitreoretinopathy［J］.J Biomed Mater Res A,2020,［Online ahead of print］.
［4］　LIU Z,LIOW S S,LAI S L,ALLI-SHAIK A,HOLDER G E,PARIKH B H,et al.Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade［J］.Nat Biomed Eng,2019,3(8):598-610.
［5］　BAINO F.Towards an ideal biomaterial for vitreous replacement:Historical overview and future trends［J］.Acta Biomater,2011,7(3):921-935.
［6］　PASU S,BELL L,ZENASNI Z,LANZ D,SIMMONDS I A,THOMPSON A,et al.Facedown positioning following surgery for large full-thickness macular hole:a multicenter randomized clinical trial［J］.JAMA Ophthalmol,2020,138(7):725-730.
［7］　WANG K,HAN Z.Injectable hydrogels for ophthalmic applications［J］.J Control Release,2017,268:212-224.
［8］　ESMAELI B,ELNER S G,SCHORK M A,ELNER V M.Visual outcome and ocular survival after penetrating trauma.A clinicopathologic study［J］.Ophthalmology,1995,102(3):393-400.
［9］　BAYOUDH W,FRENTZ M,CARSTESEN D,DITTRICH B,REISMANN C,SCHRAGE N F,et al.Intraocular silicone implant to treat chronic ocular hypotony-preliminary feasibility data［J］.Graefes Arch Clin Exp Ophthalmol,2016,254(11):2131-2139.
［10］　NORTON E W.Intraocular gas in the management of selected retinal detachments［J］.Trans Am Acad Ophthalmol Otolaryngol,1973,77(2):85-98.
［11］　BHENDE M,RAMAN R,SINGH N,JAIN M,SHARMA T,GOPAL L,et al.Risk factors for endophthalmitis after pars plana vitrectomies in a tertiary eye institute in India［J］.Ophthalmol Retina,2018,2(8):779-784.
［12］　BARTH H,CRAFOORD S,ARNER K,GHOSH F.Inflammatory responses after vitrectomy with vitreous substitutes in a rabbit model［J］.Graefes Arch Clin Exp Ophthalmol,2019,257(4):769-783.
［13］　UESUGI K,SAKAGUCHI H,HAYASHIDA Y,HAYASHI R,BABA K,SUGANUMA Y,et al.A self-assembling peptide gel as a vitreous substitute:a rabbit study［J］.Invest Ophthalmol Vis Sci,2017,58(10):4068-4075.
［14］　INOUE M,IRIYAMA A,KADONOSONO K,TAMAKI Y,YANAGI Y.Effects of perfluorocarbon liquids and silicone oil on human retinal pigment epithelial cells and retinal ganglion cells［J］.Retina,2009,29(5):677-681.
［15］　LIN X,SUN X,WANG Z,JIANG Z,LIU Y,WANG P,et al.Three-year efficacy and safety of a silicone oil-filled foldable-capsular-vitreous-body in three cases of severe retinal detachment［J］.Transl Vis Sci Technol,2016,5(1):2.
［16］　BARTH H,CRAFOORD S,ANDREASSON S,GHOSH F.A cross-linked hyaluronic acid hydrogel(Healaflow?) as a novel vitreous substitute［J］.Graefes Arch Clin Exp Ophthalmol,2016,254(4):697-703.
［17］　GAO Q Y,FU Y,HUI Y N.Vitreous substitutes:challenges and directions［J］.Int J Ophthalmol,2015,8(3):437-440.
［18］　ZENONI S,COMI N,FONTANA P,ROMANO M R.The combined use of heavy and light silicone oil in the treatment of complicated retinal detachment with 360 masculine retinal breaks:tamponade effect or filling effect?［J］.Ann Acad Med Singap,2012,41(10):440-443.
［19］　MIKHAIL M A,MANGIORIS G,BEST R M,MCGIMPSEY S,CHAN W C.Management of giant retinal tears with vitrectomy and perfluorocarbon liquid postoperatively as a short-term tamponade［J］.Eye(Lond),2017,31(9):1290-1295.
［20］　JANUSCHOWSKI K,SCHNICHELS S,HURST J,HOHENADL C,REITHER C,RICKMANN A,et al.Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute［J］.PLoS One,2019,14(1):e0209217.
［21］　SHAFAIE S,HUTTER V,BROWN M B,COOK M T,CHAU D Y S.Diffusion through the ex vivo vitreal body - Bovine,porcine,and ovine models are poor surrogates for the human vitreous［J］.Int J Pharm,2018,550(1-2):207-215.
［22］　SANTHANAM S,LIANG J,STRUCKHOFF J,HAMILTON P D,RAVI N.Biomimetic hydrogel with tunable mechanical properties for vitreous substitutes［J］.Acta Biomater,2016,43:327-337.
［23］　LIANG J,STRUCKHOFF J J,DU H,HAMILTON P D,RAVI N.Synthesis and characterization of in situ forming anionic hydrogel as vitreous substitutes［J］.J Biomed Mater Res B Appl Biomater,2017,105(5):977-988.
［24］　FENG S,CHEN H,LIU Y,HUANG Z,SUN X,ZHOU L,et al.A novel vitreous substitute of using a foldable capsular vitreous body injected with polyvinylalcohol hydrogel［J］.Sci Rep,2013,3:1838.
［25］　MORANDIM-GIANNETTI ADE A,SILVA R C,MAGALHAES O J,SCHOR P,BERSANETTI P A.Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute［J］.J Biomed Mater Res B Appl Biomater,2016，104(7):1386-1395.
［26］　CHANG J,TAO Y,WANG B,GUO B H,XU H,JIANG Y R,et al.An in situ-forming zwitterionic hydrogel as vitreous substitute［J］.J Mater Chem B，2015,3(6):1097-1105.
［27］　TAO Y,TONG X,ZHANG Y,LAI J,HUANG Y,JIANG Y R,et al.Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material［J］.Acta Biomater,2013,9(2):5022-5030.
［28］　TRAM N K,JIANG P,TORRES-FLORES T C,JACOBS K M,CHANDLER H L,SWINDLE-REILLY K E.A hydrogel vitreous substitute that releases antioxidant［J］.Macromol Biosci,2020,20(2):e1900305.
［29］　王睿,毕春潮,李凤至,孙连义.同期行硅油取出C3F8填充联合巩膜扣带术治疗硅油填充术后下方视网膜脱离患者的手术疗效［J］.眼科新进展,2016,36(8):770-772.
WANG R,BI C C,LI F Z,SUN L Y.Silicone oil removal combined with scleral buckling and C3F8 tamponade for inferior retinal detachment after silicone oil filled［J］.Rec Adv Ophthalmol，2016,36(8):770-772.
［30］　鲍庆,陈佳,邢怡桥,杜磊,梅海峰.硅油眼复发性视网膜脱离的特点及临床处理［J］.眼科新进展,2017,37(6):576-578.
BAO Q，CHEN J，XING Y Q，DU L，MEI H F.Clinical characteristics and management of recurrent retinal detachment in silicone oil tamponade eyes［J］.Rec Adv Ophthalmol，2017,37(6):576-578.
［31］　冯松福,陈晗,陆晓和,高前应.聚乙烯醇水凝胶模拟自然玻璃体的实验研究［J］.眼科新进展,2018，38(1):13-17.
FENG S F，CHEN H，LU X H，GAO Q Y.A study of polyvinyl alcohol hydrogel simulating human vitreous body［J］.Rec Adv Ophthalmol，2018，38(1):13-17.
［32］　冯松福,陈晗,陆晓和.聚乙烯醇(PVA)水凝胶填充兔玻璃体腔的安全性及有效性研究［J］.眼科新进展,2018,38(7):615-619.
FENG S F，CHEN H，LU X H.Safety and efficacy of filling the vitreous cavity with polyvinyl alcohol hydrogel in rabbits［J］.Rec Adv Ophthalmol，2018,38(7):615-619.

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备注/Memo:
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更新日期/Last Update: 2020-12-05