[1]何海龙,侯思梦,周春媛,等.不同级别豹纹状眼底对黄斑区视网膜血管密度及厚度的影响[J].眼科新进展,2020,40(9):857-861.[doi:10.13389/j.cnki.rao.2020.0195]
 HE Hailong,HOU Simeng,ZHOU Chunyuan,et al.Effects of different grades of fundus tessellation on macular retinal vessel density and thickness[J].Recent Advances in Ophthalmology,2020,40(9):857-861.[doi:10.13389/j.cnki.rao.2020.0195]
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年9期
页码:
857-861
栏目:
应用研究
出版日期:
2020-09-05

文章信息/Info

Title:
Effects of different grades of fundus tessellation on macular retinal vessel density and thickness
作者:
何海龙侯思梦周春媛赵欣宇王进达万修华
100005 北京市,首都医科大学附属北京同仁医院北京同仁眼科中心,北京市眼科研究所,北京市眼科学与视觉科学重点实验室(何海龙,侯思梦,王进达,万修华);100038 北京市,首都医科大学附属北京世纪坛医院(周春媛);100005 北京市,中国医学科学院基础医学研究所,北京协和医学院基础学院(赵欣宇)
Author(s):
HE Hailong1HOU Simeng1ZHOU Chunyuan2ZHAO Xinyu3WANG Jinda1WAN Xiuhua1
1.Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100005,China
2.Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China
3.Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005,China
关键词:
光学相干断层扫描血管成像技术近视视网膜血管密度
Keywords:
optical coherence tomography angiography myopia retinal blood flow density
分类号:
R774
DOI:
10.13389/j.cnki.rao.2020.0195
文献标志码:
A
摘要:
目的 运用光学相干断层扫描血管成像技术(optical coherence tomography angiography,OCTA)对不同级别豹纹状眼底黄斑区视网膜进行测量,探究不同级别豹纹状眼底黄斑区视网膜浅层及深层血管密度和厚度的差异。方法 前瞻性非随机对照研究。收集2019年1月至2019年6月在首都医科大学附属北京同仁医院眼科就诊的高度近视(SE<-6.00 D)眼底豹纹状改变的患者共52例(63眼),按照眼底豹纹状改变的级别将其分为四组:0级组(18眼)、1级组(22眼)、2级组(12眼)、3级组(11眼)。选取黄斑中心凹周围区、黄斑旁中心凹以及黄斑中心凹为观察指标,通过OCTA自动分层获得黄斑区视网膜浅层和深层的血管密度及视网膜厚度,采用秩和检验、方差分析以及SNK检验对数据进行分析。结果 四组患者的年龄呈非正态分布,差异无统计学意义(P=0.64)。黄斑中心凹周围区以及黄斑旁中心凹区:四组患者间视网膜浅层及深层血管密度差异均有统计学意义(均为P<0.05);视网膜厚度:以0级组作为参照组,0级组与1级组、2级组、3级组差异均有统计学意义(均为P<0.05),且呈负相关关系。在黄斑中心凹区域:四组患者间视网膜浅层及深层血管密度和黄斑区视网膜厚度差异均无统计学意义(均为P>0.05)。结论 随着豹纹状眼底级别的加深,眼底黄斑中心凹周围区以及旁中心凹区视网膜浅层及深层血管密度有统计学差异,且视网膜厚度随豹纹状眼底的级别加重呈进行性变薄趋势。OCTA可为评估不同级别豹纹状眼底视网膜的组织结构变化提供参考资料。
Abstract:
Objective To explore the effect of different grades of fundus tessellation on macular retinal superficial and deep vessel density and thickness by using optical coherence tomography angiography (OCTA).Methods This was prospective, non-randomized, controlled study. From January 2019 to June 2019, 52 patients (63 eyes) with fundus tessellation (SE<-6.00 D) was included of Beijing Tongren Hospital. We divided patients into 4 groups according to the different grades of fundus tessellation, including 0-grade group (18 eyes), 1-grade group (22 eyes), 2-grade group (12 eyes), 3-grade group (11 eyes). The macular region was divided into the fovea, the parafovea zone and the perifovea zone. Macular superficial and deep vascular density and retinal thickness were measured by OCTA. Rank-sum test, analysis of variance, SNK test were used to analyze the collected data from the four groups.Results The age of 4 groups patients showed abnormal distribution, and the difference was not statistically significant (P=0.64). In the perifovea and parafovea zone, there were significant differences in the macular retinal superficial and deep vascular density and retinal thickness (all P<0.05). As for retinal thickness, taking the 0- grade group as the reference, the difference was statistically significant between 0-grade group and 1-grade, 2-grade and 3-grade groups (all P<0.05), with a negative correlation. In the fovea: There were no significant differences in the macular retinal superficial, deep vascular density and retinal thickness (all P>0.05).Conclusion With the increasing degree of fundus tessellation, there are statistical differences in macular retinal superficial and deep vascular density of the perifovea and parafovea zone, and retinal thickness gradually becomes thinner with the increasing degree of fundus tessellation in a linear pattern. OCTA can effectively and conveniently detect the macular retinal vessel density and thickness in different grades of fundus tessellation.

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更新日期/Last Update: 2020-09-05