参考文献/References:
[1] YUAN M,HAN Y,FANG Y,CHU C I.Childbearing may increase the risk of nondiabetic cataract in Chinese women’s old age[J].J Ophthalmol,2015,2015:385815.
[2] BAE J H,SHIN D S,LEE S C,HWANG I C.Sodium intake and socioeconomic status as risk factors for development of age-related cataracts: The Korea National Health and Nutrition Examination Survey[J].PLoS One,2015,10(8):e0136218.
[3] BERBER P,GRASSMANN F,KIEL C,WEBER B H.An eye on age-related macular degeneration: the role of micrornas in disease pathology[J].Mol Diagn Ther,2017,21(1):31-43.
[4] ORANG A V,BARZEGARI A .MicroRNAs in colorectal cancer: from diagnosis to targeted therapy[J].Asian Pac J Cancer Prev,2014,15(17):6989-6999.
[5] GU S,RONG H,ZHANG G,KANG L,YANG M,GUAN H.Functional SNP in 3’-UTR microrna-binding site of znf350 confers risk for age-related cataract[J].Hum Mutat,2016,37(11):1223-1230.
[6] KUMAR S,VIJAYAN M,BHATTI J S,REDDY P H.MicroRNAs as peripheral biomarkers in aging and age-related diseases[J].Prog Mol Biol Transl Sci,2017,146:47-94.
[7] LIANG N,ZHOU X,ZHAO M,ZHAO D,ZHU Z,LI S,YANG H.Down-regulation of microRNA-26b modulates non-small cell lung cancer cells chemoresistance and migration through the association of PTEN[J].Acta Biochim Biophys Sin,2015,47(7):530-538.
[8] KHAN S Y,HACKETT S F,LEE M C,POURMAND N,TALBOT C C J,RIAZUDDIN S A.Transcriptome profiling of developing murine lens through RNA sequencing[J].Invest Ophthal Vis Sci,2015,56(8):4919-4926.
[9] CHUNZI L,HONGBO H .Downregulation of miR-26b impact on lens epithelial cells in cataract rat [J].Int J Clin Exp Pathol,2016,9(9):8784-8790.
[10] BAI J,YU N,MU H,DONG L,ZHANG X.Histidine protects human lens epithelial cells against H2O2-induced oxidative stress injury through the NF-кB pathway[J].J Cell Biochem,2018,119(2):1637-1645.
[11] SHALKAMI A S,HASSAN M I A,ABD EL-GHANY A A.Perindopril regulates the inflammatory mediators,NF-κB/TNF-α/IL-6,and apoptosis in cisplatin-induced renal dysfunction.[J].Naunyn Schmiedebergs Arch Pharmacol,2018,391(11):1247-1255.
[12] CHEN X,XIAO W,CHEN W,LIU X,WU M,BO Q,et al.MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway[J].Cell Death Differ,2017,24(8):1431-1442.
[13] LIANG H,XU C,PAN Z,ZHANG Y,XU Z,CHEN Y,et al.The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis[J].Mol Ther,2014,22(6):1122-1133.
[14] SARAVANAMUTHU S S,LE T T,GAO C Y,COJOCARU R I,PANDIYAN P,LIU C,et al.Conditional ablation of the Notch2 receptor in the ocular lens[J].Dev Biol,2012,362(2):219-229.
[15] LI Q L,ZHANG H Y,QIN Y J,MENG Q L,YAO X L,GUO H K.MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulator[J].Int J Ophthalmol,2016,9(11):1555-1560.
[16] WANG S,GUO C,YU M,NING X,YAN B,ZHAO J,et al.Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract[J].BMC Ophthalmol,2018,18(1):93.
[17] ZHENG T,LU Y .SIRT1 protects human lens epithelial cells against oxidative stress by inhibiting p53-dependent apoptosis[J].Curr Eye Res,2016,41(8):1068-1075.
[18] FAN F,ZHUANG J,ZHOU P,LIU X,LUO P.MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2[J].Oncotarget,2017,8(66):110209-110220.
[19] SUN Y M,LIN K Y,CHEN Y Q .Diverse functions of miR-125 family in different cell contexts[J].J Hematol Oncol,2013,6(1):6.
[20] QIN Y,ZHAO J,MIN X,WANG M,LUO W,WU D,et al.MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract[J].Biochim Biophys Acta,2014,1842(12):2439-2447.
[21] ZHAO Y,LI X,ZHU S .rs78378222 polymorphism in the 3’-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells[J].Mol Med Rep,2016,14(3):2305-2310.
[22] HE G Y,HU J L,ZHOU L,ZHU X H,XIN S N,ZHANG D,et al.The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer[J].Br J Cancer,2016,115(11):1367-1378.
[23] JIN X,JIN H,SHI Y,GUO Y,ZHANG H.Long non-coding RNA KCNQ1OT1 promotes cataractogenesis via miR-214 and activation of the caspase-1 pathway[J].Cell Physiol Biochem,2017,42(1):295-305.
[24] CHEN B,MA J,LI C,WANG Y.Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial-mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells[J].Mol Med Rep,2018,18(1):16-24.
[25] LU B,CHRISTENSEN I T,MA L W,WANG X L,JIANG L F,WANG C X, et al.miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts[J].Mol Med Rep,2018,17(4):5021-5028.
[26] REN H,TAO H,GAO Q,SHEN W,NIU Z,ZHANG J,et al.MiR-326 antagomir delays the progression of age-related cataract by upregulating FGF1-mediated expression of betaB2-crystallin[J].Biochem Biophys Res Commun,2018,505(2):505-510.
[27] ZENG K,FENG Q G,LIN B T,MA D H,LIU C M.Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice[J].Biosci Rep,2017,37(4):BSR20170695.
[28] ZHANG L,CHENG R,HUANG Y.miR-30a inhibits BECN1-mediated autophagy in diabetic cataract[J].Oncotarget,2017,8(44):77360-77368.
[29] XU C G,YANG M F,FAN J X,WANG W.miR-30a and miR-205 are downregulated in hypoxia and modulate radiosensitivity of prostate cancer cells by inhibiting autophagy via TP53INP1[J].Eur Rev Med Pharmacol Sci,2016,20(8):1501-1508.
[30] LIN C,WANG Z,LI L,HE Y,FAN J,LIU Z,et al.The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma[J].Appl Microbiol Biotechnol,2015,99(20):8487-8494.
[31] ZHANG L,WANG Y,LI W,TSONIS P A,LI Z,XIE L,et al.microRNA-30a regulation of epithelial-mesenchymal transition in diabetic cataracts through targeting SNAI1[J].Sci Rep,2017,7(1):1117.
[32] WU C R,YE M,QIN L,YIN Y,PEI C.Expression of lens-related microRNAs in transparent infant lenses and congenital cataract[J].Int J Ophthalmol,2017,10(3):361-365.
[33] BYKHOVSKAYA Y,SELDIN M F,LIU Y,RANSOM M,LI X,RABINOWIZ Y S.Independent origin of c.57 C > T mutation in mir184 associated with inherited corneal and lens abnormalities[J].Ophthalmic Genet,2015,36(1):95-97.
[34] BYKHOVSKAYA Y,CANEDO A L C,WRIGHT K W,RABINOWIZ Y S.C.57 C > T Mutation in MIR 184 is responsible for congenital cataracts and corneal abnormalities in a five-generation family from Galicia,Spain[J].Ophthalmic Genet,2015,36(3):244-247.
[35] KORHAN P,ERDAL E,ATABEY N.MiR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility,invasion and branching-morphogenesis by directly targeting c-Met[J].Biochem Biophys Res Commun,2014,450(4):1304-1312.
[36] DONG N,TANG X,XU B.MiRNA-181a inhibits the proliferation,migration,and epithelial-mesenchymal transition of lens epithelial cells[J].Invest Ophthalmol Vis Sci,2015,56(2):993-1001.
[37] KUBO E,SHIBATA S,SHIBATA T,KIYOKAWA E,SASAKI H,SINGH D P.FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity[J].J Cell Mol Med,2017,21(5):916-928.