[1]李冠瑜,孙丰源.非编码RNA对葡萄膜黑色素瘤发生机制影响研究新进展[J].眼科新进展,2020,40(2):197-200.[doi:10.13389/j.cnki.rao.2020.0047]
　LI Guanyu,SUN Fengyuan.Recent advances in mechanism of non-coding RNA in uveal melanoma[J].Recent Advances in Ophthalmology,2020,40(2):197-200.[doi:10.13389/j.cnki.rao.2020.0047]
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非编码RNA对葡萄膜黑色素瘤发生机制影响研究新进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年2期
页码:
197-200
栏目:
文献综述
出版日期:
2020-02-05

文章信息/Info

Title:
Recent advances in mechanism of non-coding RNA in uveal melanoma
作者:
李冠瑜; 孙丰源
300384　天津市，天津医科大学眼科医院眼视光学院眼科研究所
Author(s):
LI Guanyu; SUN Fengyuan
Eye Institute and School of Optometry，Tianjin Medical University Eye Hospital，Tianjin 300384，China
关键词:
葡萄膜黑色素瘤; 微小RNA; 长链非编码RNA; 机制
Keywords:
uveal melanoma; microRNA; long non-coding RNA; mechanism
分类号:
R773.4
DOI:
10.13389/j.cnki.rao.2020.0047
文献标志码:
A
摘要:
葡萄膜黑色素瘤是成人最常见的一种眼内原发性肿瘤，恶性程度高，患者长期存活率低，易于肝转移。MicroRNA（miRNA）是一种单链非编码微小RNA，参与调节信使RNA的转录后翻译。长链非编码RNA（lncRNA）是一种长链（长度大于200 nt）核糖核酸，不具有蛋白质编码的功能。有研究表明，miRNAs和lncRNAs在葡萄膜黑色素瘤的发生发展过程中均起到调控作用。本文总结了近五年关于miRNAs和lncRNAs对葡萄膜黑色素瘤发生机制影响研究新进展，以期发现更多的可用于该病诊疗的新靶点。
Abstract:
Uveal melanoma is one of the most common primary intraocular tumors in adults.It has a high degree of malignancy,low long-term survival rate and is prone to having liver metastasis.MicroRNA (miRNA) is a single-stranded,non-coding microRNA that regulates post-transcriptional translation of messenger RNA.Long non-coding RNA (lncRNA) is a long-chain ribonucleic acid (longer than 200 nt),which does not have the function of protein coding.Studies have shown that both miRNAs and lncRNAs play a regulatory role in the occurrence and development of uveal melanoma.The article summarizes recent advances in the study of the mechanisms of miRNAs and lncRNAs in uveal melanoma in the past five years,in order to find more new targets for diagnosis and treatment of uveal melanoma.

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更新日期/Last Update: 2020-02-05