[1]闫春妮,黄磊,宋晓瑾,等.视网膜脱离行玻璃体切除硅油填充术后继发青光眼患者房水中IL-2、IL-6、MCP-1的表达[J].眼科新进展,2019,39(12):1182-1185.[doi:10.13389/j.cnki.rao.2019.0272]
　YAN Chun-Ni,HUANG Lei,SONG Xiao-Jin,et al.Expression of IL-2，IL-6，and MCP-1 in aqueous humor of patients with secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling[J].Recent Advances in Ophthalmology,2019,39(12):1182-1185.[doi:10.13389/j.cnki.rao.2019.0272]
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视网膜脱离行玻璃体切除硅油填充术后继发青光眼患者房水中IL-2、IL-6、MCP-1的表达/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年12期
页码:
1182-1185
栏目:
应用研究
出版日期:
2019-12-05

文章信息/Info

Title:
Expression of IL-2，IL-6，and MCP-1 in aqueous humor of patients with secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling
作者:
闫春妮; 黄磊; 宋晓瑾; 程丽娜
710002　陕西省西安市，西安市第一医院眼科，陕西省眼科研究所，陕西省眼科学重点实验室（闫春妮，黄磊，程丽娜）；710002　陕西省西安市，空军军医大学西京医院眼科，全军眼科研究所（宋晓瑾）
Author(s):
YAN Chun-Ni; HUANG Lei; SONG Xiao-Jin; CHENG Li-Na
Department of Ophthalmology，Xi’an No 1 Hospital，Shaanxi Ophthalmological Institute，Shaanxi Key Laboratory of Ophthalmology （YAN Chun-Ni，HUANG Lei，CHENG Li-Na），Xi’an 710002，Shaanxi Province，China；Department of Ophthalmology，Xijing Hospital of the Air Force Military Medical University，Institute of Ophthalmology of the PLA（SONG Xiao-Jin），Xi’an 710002，Shaanxi Province，China
关键词:
视网膜脱离; 玻璃体切除硅油填充术; 继发性青光眼; 白细胞介素-2; 白细胞介素-6; 单核细胞趋化蛋白-1
Keywords:
retinal detachment; vitrectomy and silicone oil filling; secondary glaucoma; interleukin-2; interleukin-6; monocyte chemoattractant protein-1
分类号:
R775
DOI:
10.13389/j.cnki.rao.2019.0272
文献标志码:
A
摘要:
目的　探讨视网膜脱离行玻璃体切除硅油填充术后继发青光眼患者房水中白细胞介素-2（interleukin-2，IL-2）、白细胞介素-6（interleukin-6，IL-6）、单核细胞趋化蛋白-1（monocyte chemotactic protein-1，MCP-1）的表达及意义。方法　回顾性分析本院2015年6月至2016年12月视网膜脱离行玻璃体切除硅油填充术后继发青光眼患者24例（继发青光眼组）及眼压正常行硅油取出术患者50例（对照组），检测2组患者房水中IL-2、IL-6、MCP-1水平，并分析其相关性及对术后继发青光眼的预测价值。结果　继发青光眼组患者房水中IL-2、IL-6和MCP-1水平分别为（0.28±0.04）μg·L-1、（18.21±2.17）ng·L-1、（3.96±0.46）μg·L-1，均显著高于对照组患者［（0.19±0.03）μg·L-1、（10.49±2.32）ng·L-1、（3.07±0.44）μg·L-1］（均为P＜0.05）；继发青光眼组患者房水中IL-2与IL-6呈正相关（r=0.616，P=0.000）；IL-2与MCP-1呈正相关（r=0.594，P=0.000）；IL-6与MCP-1呈正相关（r=0.608，P=0.000）。房水中IL-2预测视网膜脱离行玻璃体切除硅油填充术后继发青光眼ROC曲线下面积（area under curve，AUC）为0.845，敏感度为75.0%，特异度为90.0%；房水中IL-6预测术后继发青光眼AUC为0.896，敏感度为70.8%，特异度为95.9%；房水中MCP-1预测术后继发青光眼AUC为0.872，敏感度为87.5%，特异度为80.0%；三者联合检测的AUC为0.978，敏感度为91.7%，特异度为96.0%。结论　视网膜脱离行玻璃体切除硅油填充术后继发青光眼患者房水中IL-2、IL-6、MCP-1水平升高，三者联合检测对术后继发青光眼预测价值高于三者单独检测，对术后筛查青光眼具有一定的参考价值。
Abstract:
Objective　To investigate the levels and significances of interleukin-2 (IL-2)，interleukin-6 (IL-6)，and monocyte chemoattractant protein-1 (MCP-1)in aqueous humor of patients with secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling.Methods　From June 2015 to December 2016，24 patients with secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling (secondary glaucoma group) and patients with normal intraocular pressure who underwent silicone oil removal (control group) were retrospectively analyzed，and the levels of IL-2，IL-6，and MCP-1 in aqueous humor of the two groups were measured，and the correlation and their predictive values for secondary glaucoma after operation were analyzed.Results　The levels of IL-2，IL-6，and MCP-1 in aqueous humor of secondary glaucoma patients were (0.28±0.04)μg· L-1，(18.21±2.17)ng·L-1，(3.96±0.46)μg·L-1，respectively，which were significantly higher than those of the control group ［(0.19±0.03)μg· L-1，(10.49±2.32)ng·L-1，(3.07±0.44)μg·L-1］ (all P<0.05)；there was a positive correlation between IL-2 and IL-6 in aqueous humor of secondary glaucoma patients (r=0.616，P=0.000)；IL-2 and IL-6 was positively correlated with MCP-1 (r=0.594，0.608，both P=0.000)；the area under the ROC curve (ACU) of IL-2 in aqueous humor for predicting secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling was 0.845，sensitivity was 75.0%，specificity was 90.0%；the ACU of IL-6 in aqueous humor for predicting secondary glaucoma after operation was 0.896，sensitivity was 70.80%，specificity was 95.9%；the ACU of MCP-1 in aqueous humor for predicting secondary glaucoma after operation was 0.872，sensitivity was 87.5%，specificity was 80.0%；the ACU of combined detection in aqueous humor for predicting secondary glaucoma after operation was 0.978，the sensitivity was 91.70%，and the specificity was 96.0%.Conclusion　The levels of IL-2，IL-6 and MCP-1 increase in aqueous humor of patients with secondary glaucoma after vitrectomy for retinal detachment and silicone oil filling，and the predictive value of combined detection for secondary glaucoma after operation is higher than that of single detection，and it has reference value for screening glaucoma after operation.

参考文献/References:

［1］　KOKAVEC J，WU Z，SHERWIN J C，ANG A J，ANG G S.Nd：YAG laser vitreolysis versus pars plana vitrectomy for vitreous floaters［J］.Cochrane Database Syst Rev，2017，6（1）：1-18.
［2］　NARANG P，AGARWAL A，AGARWAL A.Single-pass four-throw pupilloplasty for secondary angle-closure glaucoma associated with silicon oil tamponade［J］.Eur J Ophthalmol，2018，1（1）：1-5.
［3］　CAI C H，HUANG C L，LI H，LV S，ZHANG Y Y，SONG S F.Correlations between IL-2/IL-6 levels and retinal nerve fiber layer damage in primary angle-closure glaucoma［J］.Immunol J，2016，32（9）：790-794.
蔡春华，黄翠玲，李华，吕莎，张永烨，宋胜仿.IL-2、IL-6与原发性闭角型青光眼视网膜神经纤维层损伤的相关性研究［J］.免疫学杂志，2016，32（9）：790-794.
［4］　ZHANG Y，YANG Q M，GUO F，CHEN X，XIE L.Levels of multiple inflammatory cytokines in aqueous humor of patients with chronic primary angle-closure glaucoma［J］.Ophthalmol CHN，2017，26（4）：229-233.
张勇，杨钦媚，郭凤，陈侠，谢琳.慢性闭角型青光眼患者房水中炎症因子浓度升高［J］.眼科，2017，26（4）：229-233.
［5］　JANCO L，TKACOVA VILLEMOVA K，ONDREJKOVA M，VIDA R，BARTOS M，MESAROSOVA M.Retinal tamponade with silicone oil—long term results［J］.Cesk Slov Oftalmol，2014，70（5）：178-182.
［6］　RIZZO S，BARCA F.Vitreous substitute and tamponade substances for microincision vitreoretinal surgery［J］.Dev Ophthalmol，2014，54（1）：92-101.
［7］　LAI C C，CHEN Y P，WANG N K，CHUANG L H，LIU L，CHEN K J，et al.Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes［J］.Ophthalmology，2015，122（9）：1889-1898.
［8］　SCHEERLINCK L M，SCHELLEKENS P A，LIEM A T，STEIJNS D，LEEUWEN R V.Incidence，risk，factors，and clinical characteristics of unexplained visual loss after intraocular silicone oil for macula—on retinal detachment［J］.Retina，2016，36（2）：342-350.
［9］　TEKE M，ELGIN U，SEN E，OZDAL P，OZTURK F.Intravitreal silicone oil induced changes in corneal biomechanics［J］.Int Ophthalmol，2014，34（3）：457-463.
［10］　ROSCA C，MUNTEANU M，TAMASOI I，PETROVIC Z，BALICA N，NICULA C，et al.Calcification of hydrophilic acrylic intraocular lens in eyes with silicone oil tamponade—an interventional case series report［J］.Acta Ophthalmol，2016，94（6）：625-627.
［11］　FEREYDOUN F，MOSTAFA F，FARSHAD O，ALIVAND A.Pars plana vitrectomy and silicone oil injection in phakic and pseudophakic eyes；corneal endothelial changes［J］.J Ophthalmic Vis Res，2014，9（3）：310-313.
［12］　SCHWARTZ S，FLYNN H，LEE W，WANG X.Tamponade in surgery for retinal detachment associated with proliferative vitreoretinopathy［J］.Cochrane Database Syst Rev，2014，14（2）：1-41.
［13］　YANG X，HONDUR G，TEZEL G.Antioxidant treatment limits neuroinflammation in experimental glaucoma［J］.Invest Ophthalmol Vis Sci，2016，57（4）：2344-2354.
［14］　OHIRA S，INOUE T，IWAO K，TAKAHASHI E，TANIHARA H.Factors influencing aqueous proinflammatory cytokines and growth factors in uveitic glaucoma［J］.PLoS One，2016，11（1）：1-13.
［15］　JIANG Y N，CHEN N H.Mechanism of CCL2/MCP-1 in its relevant diseases［J］.Chin Pharmacol Bull，2016，32（12）：1634-1638.
姜懿纳，陈乃宏.CCL2/MCP-1在其相关疾病的机制研究［J］.中国药理学通报，2016，32（12）：1634-1638.
［16］　WANG Y，CHEN S，LIU Y，HUANG W，LI X，ZHANG X.Inflammatory cytokine profiles in eyes with primary angle-closure glaucoma［J］.Biosci Rep，2018，38（6）：BSR20181411.
［17］　PROWLE J，CALZAVACCA P，LICARI E，LIGABO E V，ECHEVERRI J E，BAGSHAW S M，et al.Combination of biomarkers for diagnosis of acute kidney injury after cardiopulmonary bypass［J］.Ren Fail，2015，37（3）：1-9.

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更新日期/Last Update: 2019-12-17