[1]王烽,邵毅,闵幼兰,等.光学相干断层扫描血管造影在翼状胬肉患者角膜厚度测量中的应用[J].眼科新进展,2019,39(10):932-936.[doi:10.13389/j.cnki.rao.2019.0212]
　WANG Feng,SHAO Yi,MIN You-Lan,et al.Optical coherence tomography angiography in the measurement of corneal thickness in pterygium patients[J].Recent Advances in Ophthalmology,2019,39(10):932-936.[doi:10.13389/j.cnki.rao.2019.0212]
点击复制

光学相干断层扫描血管造影在翼状胬肉患者角膜厚度测量中的应用/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年10期
页码:
932-936
栏目:
应用研究
出版日期:
2019-10-05

文章信息/Info

Title:
Optical coherence tomography angiography in the measurement of corneal thickness in pterygium patients
作者:
王烽; 邵毅; 闵幼兰; 杨林; 吴威; 徐曼薇; 高桂平
330006　江西省南昌市，南昌大学第一附属医院眼科
Author(s):
WANG Feng; SHAO Yi; MIN You-Lan; YANG Lin; WU Wei; XU Man-Wei; GAO Gui-Ping
Department of Ophthalmology，the First Affiliated Hospital of Nanchang University，Nanchang 330006，Jiangxi Pro-vince，China
关键词:
翼状胬肉; 光学相干断层扫描血管造影; 角膜全层厚度; 角膜上皮厚度
Keywords:
pterygium; optical coherence tomography angiography; corneal whole layer thickness; corneal epithelial thickness
分类号:
R777.33
DOI:
10.13389/j.cnki.rao.2019.0212
文献标志码:
A
摘要:
目的　通过光学相干断层扫描血管造影（optical coherence tomography angiography，OCTA）技术检测翼状胬肉患者翼状胬肉周边角膜各区域厚度及上皮厚度的变化。方法　选取翼状胬肉女性患者（右眼，翼状胬肉组）和正常女性（右眼，正常组）各44人。用OCTA技术分别对翼状胬肉组和正常组角膜各区域全层厚度及上皮厚度进行测量。对角膜进行25分区，中央区（M2）为角膜中央2 mm区域，内环、中环、外环直径范围分别为距角膜中央5 mm、7 mm和9 mm。将角膜的内环、中环和外环的每个区域划分为下方(I)、颞下(IT)、颞侧(T)、颞上(ST)、上(S)、鼻上(SN)、鼻侧(N)以及鼻下(IN)8个方位。翼状胬肉组各区域(除翼状胬肉区域SN、N、IN区外)与正常组角膜对应区域全层厚度及上皮厚度进行两两比较。结果　翼状胬肉组角膜的上方（S5、S7、S9区），下方（I5、I7、I9区）角膜全层及上皮厚度均较正常组角膜厚（均为 P<0.05），中央区及其他区域角膜全层厚度差异均无统计学意义（均为P>0.05）。角膜的S5、S7、S9区为翼状胬肉组各环中角膜上皮所占角膜总厚度比例最大的区域，角膜的IT5、IT7、IT9区为所占比例最小的区域。IT5、T7、T9区为正常组各环角膜上皮所占角膜总厚度比例最大的区域，S5、S7、S9区为所占比例最小的区域。中央区（M2）角膜上皮占各角膜全层厚度的比例最大，从内到外逐渐下降。结论　OCTA技术可以发现翼状胬肉患者上下方角膜厚度和角膜上皮厚度明显增厚。
Abstract:
Objective　To investigate the whole layer thickness of cornea around pterygium,and the alteration in epithelial thickness in pterygium patients by using the optical coherence tomography angiography (OCTA).Methods　Totally 44 right eyes from female pterygium patients (pterygium group) and 44 right eyes from female healthy control subjects (healthy control group) were selected in the study.OCTA was applied to measure the thickness of each zone in whole layers and epithelial thickness in cornea of each subject.The cornea was divided into 25 zones with a diameter of 2 mm in centre,a diameter of 5 mm for inner ring,7 mm for middle ring,and 9 mm for outer ring.Each region of the inner,middle and outer ring of the cornea was divided into 8 directional zones,namely,inferior (I),inferior temporal (IT),lateral temporal (T),superior temporal (ST),superior temporal (S),superior nasal (SN),nasal side (N),and inferior nasal (IN).Pairwise comparison of corneal whole layer thickness and epithelial thickness between the pterygium group and the healthy control group was conducted for all regions (except the pterygium zones of SN,N,IN).Results　Compared with the healthy control group,the whole layer thickness and epithelial thickness in the top cornea (S5 and S7,S9 zone),below (I5 and I7,and I9 zone) cornea in pterygium group were significantly increased (all P<0.05).However,no statistical differences were observed in the whole layer thickness of the central and the other zones in cornea between the two groups (all P>0.05).In addition,in the pterygium group,S5 and S7,and S9 zones of each corneal ring were shown to be the ones with highest percentage of epithelial thickness/the whole layer thickness,while IT5,IT7,and IT9 zones were shown to be the ones with lowest percentage of epithelial thickness/the whole layer thickness.However,in the healthy control group,IT5,T7 and T9 zones of each corneal ring were shown to be the ones with highest percentage of epithelial thickness/the whole layer thickness,while S5,S7,and S9 zones were shown to be the ones with lowest percentage of epithelial thickness/the whole layer thickness.Besides,the central corneal epithelium (M2) was shown to be the one with the highest percentage of epithelial thickness/the whole layer thickness with a gradual decrease from the inner ring to the outer ring.Conclusion　OCTA can be applied to detect the significant increases in thickness of upper and lower cornea and epithelial thickness of cornea in pterygium patients.

参考文献/References:

［1］　PEI R，GAO H，XU S Y，ZHANG M.Expression of CD105，TGF-1 and iNOS in pterygium and its significance［J］.J Clin Res，2015，32 (12)：2429-2431.
裴瑞，高珩，许淑云，张萌.CD105、TGF-β1与iNOS在翼状胬肉中的表达及其意义［J］.医学临床研究，2015，32(12)：2429-2431.
［2］　GONEN T，SEVER O，HOROZOGLU F，YASAR M，KESKINBORA K H.Endothelial cell loss：Biaxial small-incision torsional phacoemulsification versus biaxial small-incision longitudinal phacoemulsification［J］.J Cataract Refract Surg，2012，38(11)：1918-1924.
［3］　ZHU N，ZHANG Z C.Phacoemulsification of cataract and corneal endothelial cell injury［J］.Int Eye Sci，2013，13 (7)：1344-1347.
朱妮，张仲臣.白内障超声乳化手术与角膜内皮细胞损伤［J］.国际眼科杂志，2013，13(7)：1344-1347.
［4］　FERNANDES M，SANGWAN V S，BANSAL A K，GANGOPADHYAY N，SRIDHAR M S，GARG P，et al.Outcome of pterygium surgery：analysis over 14 years［J］.Eye，2005，19(11)：1182-1190.
［5］　ZHU P W，ZOU X X，LIU K C，HAN Y，LIN Z R，YE L，et al.Clinical study on optical coherence tomography angiography (OCTA) in corneal thickness measurement［J］.Rec Adv Ophthalmol，2017，37(8)：732-735.
朱佩文，邹雪香，刘康成，韩云，林志荣，叶蕾，等.光学相干断层扫描血管造影(OCTA)在角膜厚度测量中的临床研究［J］.眼科新进展，2017，37(8)：732-735.
［6］　FRANCOZ M，KARAMOKO I，BAUDOUIN C，LABB A.Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography［J］.Invest Ophthalmol Vis Sci，2011，52(12)：9116-9123.
［7］　ROCHA K M，STRAZIOTA C P，STULTING R D，RANDLEMAN J B.Spectral-Domain OCT analysis of regional epithelial thickness profiles in keratoconus，postoperative corneal ectasia，and normal eyes［J］.J Refract Surg，2013，29(3)：173-179.
［8］　ANG M，SIM D A，KEANE P A，SNG C C A，EGAN C，TUFAIL A，et al.Optical coherence tomography angiography for anterior segment vasculature imaging［J］.Ophthalmology，2015，122(9)：1740-1747.
［9］　SPAIDE R F，JR K J，COONEY M J.Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography［J］.JAMA Ophthalmol，2015，133(1)：45-50.
［10］　PAN Z Q.Corneal stem cells and limbal defects［J］.Int Ophthalmol Surv，1996，20(4)：303-309.
潘志强.角膜干细胞和角膜缘缺陷症［J］.国际眼科纵览，1996，20(4)：303-309.
［11］　ZHOU J Q，ZHOU X T.New progress in corneal thickness measurement［J］.Int Ophthalmol Surv，2007，31(4)：239-242.
周佳奇，周行涛.角膜厚度测量新进展［J］.国际眼科纵览，2007，31(4)：239-242.
［12］　JIA Y，WEI E，WANG X，ZHANG X，MORRISON J C，PARIKH M，et al.Optical coherence tomography angiography of optic disc perfusion in glaucoma［J］.Ophthalmology，2014，121(7)：1322-1332.
［13］　JIA Y，TAN O，TOKAYER J，POTSAID B，WANG Y，LIU J J，et al.Split-spectrum amplitude-decorrelation angiography with optical coherence tomography［J］.Opt Express，2012，20(4)：4710-4725.
［14］　MIWA Y，MURAKAMI T，SUZUMA K，UJI A，YOSHITAKE S，FUJIMOTO M，et al.Relationship between functional and structural changes in diabetic vessels in optical coherence tomography angiography［J］.Sci Rep，2016，6：29064.
［15］　DONG X F，ZHONG H.Research progress of angi-oct in the clinical application of ophthalmic diseases［J］.Rec Adv Ophthalmol，2016，36(7)：697-700.
董秀芬，钟华.Angio-OCT在眼科疾病临床应用中研究进展［J］.眼科新进展，2016，36(7)：697-700.
［16］　ANG M，CAI Y，SHAHIPASAND S，SIM D A，KEANE P A，SNG C C A，et al.Enface optical coherence tomography angiography for corneal neovascularisation［J］.Br J Ophthalmol，2016，100(5)：616-621.
［17］　WANG Y，ZHAO F，ZHU W，XU J，ZHENG T，SUN X.In vivo confocal microscopic evaluation of morphologic changes and dendritic cell distribution in pterygium［J］.Am J Ophthalmol，2010，150(5)：650-655.
［18］　ECKARD A，STAVE J，GUTHOFF R F.In vivo investigations of the corneal epithelium with the confocal Rostock Laser Scanning Microscope (RLSM)［J］.Cornea，2006，25(2)：127-131.
［19］　WANG H S，QU H Q，CHU Y，YANG Y F，HONG J，WANG W，et al.Analysis and application of in vivo confocal microscopy in preoperative histopathological characteristics of primary pterygium［J］.Chin J Pract Ophthalmol，2013，31 (1)：50-54.
王昊舒，曲洪强，初颖，杨艳芳，洪晶，王薇，等.活体共聚焦显微镜在原发性翼状胬肉术前组织病理学特点分析应用［J］.中国实用眼科杂志，2013，31(1)：50-54.
［20］　YANG X Q，LI S S，XIANG W，ZHUANG W J，ZHAO J J.3 d - OCT，the Orbscan Ⅱ with ultrasonic corneal thickness gauge comparison of measuring central corneal thickness［J］.Ningxia Med J，2013，35 (1)：9-11.
杨学秋，李珊珊，向伟，庄文娟，赵静静.3D-OCT、OrbscanⅡ与超声角膜测厚仪测量中央角膜厚度的比较［J］.宁夏医学杂志，2013，35(1)：9-11.

相似文献/References:

[1]吴恺 刘二华 谭钢 邵毅.雷公藤多甙对体外培养的人翼状胬肉上皮鳞状化生的影响[J].眼科新进展,2012,32(6):000.
[2]叶芬 田农 薛春燕 施宇华 曹茜 黄振平.翼状胬肉面积与术后残余像差之间的关系[J].眼科新进展,2013,33(1):000.
[3]贾烨 赖兆光.翼状胬肉切除术式对术后眼表修复的影响[J].眼科新进展,2013,33(1):000.
[4]李新宇 王娟 徐玲娟 胡军 胡维琨 李贵刚.绷带型角膜接触镜在翼状胬肉手术中的应用[J].眼科新进展,2013,33(8):000.
[5]李景翠 张雪菲.组织因子在翼状胬肉中的表达[J].眼科新进展,2012,32(2):000.
[6]彭立 谢青 蔡枫 李爱国.同步辐射微束X射线检测翼状胬肉实验条件的探讨[J].眼科新进展,2013,33(11):000.
[7]石一宁,张纯涛.TGF-β1、TGF-βRⅡ及Smad4蛋白在原发性翼状胬肉中的表达[J].眼科新进展,2010,30(5):000.
[8]黄 焱 杨 静 张 娣 马惠杰 廖 凯沈 平 袁 安.自体角膜缘干细胞移植与常规翼状胬肉切除术疗效比较[J].眼科新进展,2009,29(1):000.
[9]范少君,陈元芝.细胞生长因子与翼状胬肉的关系研究新进展[J].眼科新进展,2014,34(5):494.[doi:10.13389/j.cnki.rao.2014.0136]
　FAN Shao-Jun,CHEN Yuan-Zhi.Relationship between cell growth factor and pterygium[J].Recent Advances in Ophthalmology,2014,34(10):494.[doi:10.13389/j.cnki.rao.2014.0136]
[10]张海江,霍鸣,董洁玉,等.核心蛋白多糖抑制翼状胬肉成纤维细胞增生的实验研究[J].眼科新进展,2014,34(8):725.[doi:10.13389/j.cnki.rao.2014.0198]
　ZHANG Hai-Jiang,HUO Ming,DONG Jie-Yu,et al.Inhibitive effects of Decorin on proliferation of cultured human pterygium fibroblasts[J].Recent Advances in Ophthalmology,2014,34(10):725.[doi:10.13389/j.cnki.rao.2014.0198]

备注/Memo

备注/Memo:
江西省自然科学基金资助（编号：20181BAB205034）；江西省教育厅科技计划项目(编号：GJJ170048)；江西省卫计委科技计划项目(编号：201810311210291002)
更新日期/Last Update: 2019-10-12