[1]刘欣欣,卢爱东,王亚星,等.北方社区中老年人群血浆中同型半胱氨酸水平与视网膜血管直径的相关性研究[J].眼科新进展,2019,39(8):785-789.[doi:10.13389/j.cnki.rao.2019.0179]
 LIU Xin-Xin,LU Ai-Dong,WANG Ya-Xing,et al.Correlation between homocysteine and retinal vessel diameter in the middle-aged and elderly in a northern community[J].Recent Advances in Ophthalmology,2019,39(8):785-789.[doi:10.13389/j.cnki.rao.2019.0179]
点击复制

北方社区中老年人群血浆中同型半胱氨酸水平与视网膜血管直径的相关性研究/HTML
分享到:

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年8期
页码:
785-789
栏目:
应用研究
出版日期:
2019-08-05

文章信息/Info

Title:
Correlation between homocysteine and retinal vessel diameter in the middle-aged and elderly in a northern community
作者:
刘欣欣卢爱东王亚星魏文斌陈朔华吴寿岭
063000 河北省唐山市,开滦总医院眼科(刘欣欣,卢爱东);100730 北京市,首都医科大学附属北京同仁医院北京同仁眼科中心(王亚星,魏文斌);063000 河北省唐山市,开滦员工健康保健中心(陈朔华);063000 河北省唐山市,开滦总医院心内科(吴寿岭)
Author(s):
LIU Xin-XinLU Ai-DongWANG Ya-XingWEI Wen-BinCHEN Shuo-HuaWU Shou-Ling
Department of Ophthalmology,Kailuan General Hospital(LIU Xin-Xin,LU Ai-Dong),Tangshan 063000,Hebei Province,China;Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University(WANG Ya-Xing,WEI Wen-Bin),Beijing 100730,China;The Kailuan Employees Health Care Center(CHEN Shuo-Hua),Tangshan 063000,Hebei Province,China;Department of Cardiology,Kailuan General Hospital(WU Shou-Ling),Tangshan 063000,Hebei Province,China
关键词:
同型半胱氨酸视网膜中央动脉直径视网膜中央静脉直径动静脉比
Keywords:
homocysteinecentral retinal artery equivalentcentral retinal vein equivalentarteriovenous ratio
分类号:
R774
DOI:
10.13389/j.cnki.rao.2019.0179
文献标志码:
A
摘要:
目的 探讨中老年人血浆中同型半胱氨酸(homocysteine,Hcy)水平与视网膜血管直径之间的关系。方法 本研究为横断面研究,研究人群为开滦研究中参加2012-2013年健康体检人群(年龄≥40岁),其中行眼底彩照者3447人,应用软件分析视网膜血管直径。最终纳入统计分析共3401人,分析血浆中Hcy水平对视网膜中央动脉直径(central retinal artery equivalent,CRAE)、视网膜中央静脉直径(central retinal vein equivalent,CRVE)和动静脉比(arteriovenous ratio,AVR)的影响。将基线Hcy水平四分位分组,用 Logistic 回归分析不同Hcy水平分组对AVR的影响。结果 本研究共入选3401人,其中男1910人、女1491人,年龄(56.81±10.17)岁,Hcy为0.09~70.60(15.27±9.11)mmol·L-1,其中CRAE为(174.29±24.59)μm,CRVE为(281.74±28.66)μm,AVR 为0.62±0.11。Hcy四分位数分别为9.50 mmol·L-1、13.30 mmol·L-1和18.20 mmol·L-1。Spearman相关分析显示,血浆中Hcy水平与CRAE呈负相关(r=-0.125,P<0.001),与CRVE呈负相关(r=-0.093,P<0.001),Hcy与AVR呈负相关(r=-0.050,P=0.004)。将Hcy分别和CRAE、CRVE和AVR进行多因素线性回归分析显示,Hcy是CRAE(β=-0.147)、CRVE(β=-0.120)的影响因素(均为P<0.05)。Logistic回归分析不同Hcy分位值对AVR的影响发现,其不是AVR的危险因素。性别分层后进一步行多因素线性回归分析发现,男性血浆中Hcy水平与CRAE(β=-0.132)、CRVE(β=-0.136)均有相关性(均为P<0.05)。结论 CRAE和CRVE均随着血浆中Hcy水平的增加而变窄,而这种现象似乎只发生在男性人群中。
Abstract:
Objective To investigate the relationship between the level of plasma homocysteine (Hcy) and retinal vessel diameter in middle-aged and elderly people.Methods This study was a cross-sectional study,and the subjects were from the Kailuan study in 2012-2013 (age≥40 years).Totally 3447 individuals had an analytical results of fundus color check.The retinal vascular diameter was analyzed by software and 3401 individuals were finally included in the statistical analysis.The effects of plasma Hcy on central retinal artery equivalent (CRAE),central retinal vein equivalent (CRVE) and arteriovenous ratio (AVR) were analyzed.The baseline Hcy level was divided into four sub-groups by quartiles,and Logistic regression was used to analyze the effects of different Hcy groups on AVR.Results Totally 3401 individuals were selected in this study,including 1910 males and 1491 females.The mean age was(56.81±10.17)years.The value of Hcy was (0.09-70.6)(15.27±9.11)mmol·L-1,CRAE was (174.29±24.59)μm,CRVE was(281.74±28.66)μm and AVR was (0.62±0.11),respectively.The quartiles of Hcy were 9.50 mmol·L-1,13.30 mmol·L-1 and 18.20 mmol·L-1,respectively.Spearman correlation analysis showed that Hcy was negatively correlated with CRAE(r=-0.125,P<0.001),CRVE (r=-0.093,P<0.001),and AVR(r=-0.050,P=0.004).Multivariate linear regression analysis showed that Hcy was a risk factor of CRAE (β=-0.147) and CRVE (β=-0.120) (both P<0.05).Logistic regression analysis of the effects of different Hcy level on AVR showed that it was not a risk factor for AVR.After gender stratification,further multivariate linear regression analysis showed that plasma Hcy was a risk factor for CRAE(β=-0.132)and CRVE(β=-0.136)in male person(both P<0.05).Conclusion CRVE and CRVE get narrow with the increase of plasma Hcy levels and this phenomenon seems to occur only in the male population.

参考文献/References:

[1] PENG H Y,MAN C F,XU J,FAN Y.Elevated homocysteine levels and risk of cardiovascular and all-cause mortality:a meta-analysis of prospective studies[J].J Zhejiang Univ Sci B,2015,16(1):78-86.
[2] KATSIKI N,PEREZ-MARTINEZ P,MIKHAILIDIS D P.Homocysteine and non-cardiac vascular disease[J].Curr Pharm Des,2017,23(22):3224-3232.
[3] IBRAHIM A S,MANDER S,HUSSEIN K A,ELSHERBINY N M,SMITH S B,AI-SHABRAWEY M,et al.Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration[J].Oncotarget,2016,7(8):8532-8545.
[4] LI J,ZHANG H,SHI M,YAN L,XIE M.Homocysteine is linked to macular edema in type 2 diabetes[J].Curr Eye Res,2014,39(7):730-735.
[5] Al WADANI F,KHANDEKAR R,SALIM G,AI ALI M,RAMZI S.Hyperhomocysteinia is a risk factor for retinal venous occlusion:a case control study[J].Indian J Ophthalmol,2014,62(3):291-294.
[6] HOWARD K P,KLEIN B E,DREYER J O,DANFORTH L G,KLEIN R.Cross-sectional associations of medication and supplement use with retinal vascular diameter in the Beaver Dam Eye Study[J].JAMA Ophthalmol,2014,132(1):23-31.
[7] Population and Employment Statistics Department and National Statistics Bureau,China population statistical yearbook[M].Beijing:China Statistical Publishing House,2006:74-76.
国家统汁局人口和就业统计司.中国人口统计年鉴(2006)[M].北京:中国统计出版社,2006:74-76.
[8] YAO T,WANG Z F,LI L,LI W,YANG H,CHEN S H,et al.Relations between serum homocysteinemia and carotid artery plapues[J].Chin J Epidemiol,2012,33(8):846-849.
姚涛,王张锋,李丽,李雯,杨慧,陈朔华,等.血浆同型半胱氨酸水平与颈动脉斑块的相关性研究[J].中华流行病学杂志,2012,33(8):846-849.
[9] WANG L,CUI L,WANG Y,VAIDYA A,CHEN S,ZhANG C,et al.Resting heart rate and the risk of developing impaired fasting glucose and diabetes:the Kailuan prospective study[J].Int J Epidemiol,2015,44(2):689-699.
[10] KNUDTSON M D,LEE K E,HUBBARD L D,WONG T Y,KLEIN R,KLEIN B E.Revised formulas for summarizing retinal vessel diameters[J].Curr Eye Res,2003,27(3):143-149.
[11] LAI W K,KAN M Y.Homocysteine-induced endothelial dysfunction[J].Ann Nutr Metab,2015,67(1):1-12.
[12] De SILVA D A,MANZANO J J,WOON F P,LIU E Y,LEE M P,GAN H Y,et al.Associations of retinal microvascular signs and intracranial large artery disease[J].Stroke,2011,42(3):812-814.
[13] ZHU Y,WANG J,MENG X,LIU G F,GAO X X.Effects of blood pressure,lipid and glucose on retinal vessel diameter[J].Rec Adv Ophthalmol,2015,35(5):470-472.
朱岩,汪军,孟忻,刘广峰,高新晓.血压、血脂和血糖对视网膜血管直径的影响[J].眼科新进展,2015,35(5):470-472.
[14] BAO S,HUANG W,LIANG Y,JING L,WANG F,PENG Y,et al.Retinal vessel diameter and chronic kidney disease in rural China:a cross-sectional study[J].Medicine (Baltimore),2015,94(49):e2076.
[15] GOPINATH B,WANG J J,FLOOD V M,BURLUTSKY G,WONG T Y,MITCHELL P.The associations between blood levels of homocysteine,folate,vitamin B12,and retinal vascular caliber[J].Am J Ophthalmol,2009,148(6):902-909.
[16] Van HECKE M V,DEKKER J M,NIJPELS G,TEERLINK T,JAKOBS C,STOLK R P,et al.Homocysteine,S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities:the Hoorn Study[J].Clin Sci,2008,114(7):479-487.
[17] OMAE T,NAGAOKA T,TANANO I,YOSHIDA A.Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production[J].Invest Ophthalmol Vis Sci,2013,54(3):2288-2295.

相似文献/References:

[1]马宇 刘意 郭娟 周利晓.金纳多联合血栓通对视网膜静脉阻塞患者同型半胱氨酸水平的影响[J].眼科新进展,2013,33(9):000.
[2]黄漓莉,于健,周素娴,等.同型半胱氨酸和视黄醇结合蛋白4与糖尿病视网膜病变的相关性研究[J].眼科新进展,2016,36(3):244.[doi:10.13389/j.cnki.rao.2016.0065]
 HUANG Li-Li,YU Jian,ZHOU Su-Xian,et al.Correlation analysis of Hcy and RBP4 with diabetic retinopathy[J].Recent Advances in Ophthalmology,2016,36(8):244.[doi:10.13389/j.cnki.rao.2016.0065]
[3]马晓敏,刘丹.视网膜静脉阻塞患者血小板参数及同型半胱氨酸水平的临床分析[J].眼科新进展,2017,37(10):973.[doi:10.13389/j.cnki.rao.2017.0247]
 MA Xiao-Min,LIU Dan.Clinical analysis of platelet parameters and homocysteine in patients with retinal vein occlusion[J].Recent Advances in Ophthalmology,2017,37(8):973.[doi:10.13389/j.cnki.rao.2017.0247]
[4]秦丰,任佳绪,耿雯,等.糖尿病患者血清中同型半胱氨酸水平与视网膜神经节细胞层厚度的相关性研究[J].眼科新进展,2018,38(6):542.[doi:10.13389/j.cnki.rao.2018.0126]
 QIN Feng,REN Jia-Xu,GENG Wen,et al.Correlation between serum homocysteine level and retinal ganglion cell layer thickness in diabetic patients[J].Recent Advances in Ophthalmology,2018,38(8):542.[doi:10.13389/j.cnki.rao.2018.0126]
[5]徐卫星,徐军.糖尿病视网膜病变患者血清同型半胱氨酸、维生素B12及叶酸与氧化应激的关系[J].眼科新进展,2018,38(6):556.[doi:10.13389/j.cnki.rao.2018.0130]
 XU Wei-Xing,XU Jun.Correlation of serum homocysteine,vitamin B12 and folic acid with oxidative stress in patients with diabetic retinopathy[J].Recent Advances in Ophthalmology,2018,38(8):556.[doi:10.13389/j.cnki.rao.2018.0130]

更新日期/Last Update: 2019-07-31