[1]王爔烔,朱勤,胡敏,等.视网膜感光神经节细胞研究进展[J].眼科新进展,2019,39(4):379-384.[doi:10.13389/j.cnki.rao.2019.0087]
 WANG Xi-Tong,ZHU Qin,HU Min,et al.Research progress on intrinsically photosensitive retinal ganglion cells[J].Recent Advances in Ophthalmology,2019,39(4):379-384.[doi:10.13389/j.cnki.rao.2019.0087]
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视网膜感光神经节细胞研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年4期
页码:
379-384
栏目:
文献综述
出版日期:
2019-04-05

文章信息/Info

Title:
Research progress on intrinsically photosensitive retinal ganglion cells
作者:
王爔烔朱勤胡敏周圆
650021 云南省昆明市,昆明医科大学第四附属医院眼科,云南省眼科研究所,云南省眼科疾病研究重点实验室
Author(s):
WANG Xi-TongZHU QinHU MinZHOU Yuan
Department of Ophthalmology,the Fourth Affiliated Hospital of Kunming Medical University,Kunming 650021,Yunnan Province,China
关键词:
视网膜感光神经节细胞黑视素成像视觉非成像视觉生理功能
Keywords:
intrinsically photosensitive retinal ganglion cellsmelanopsinvisual imagingnon-imaging visionphysiological function
分类号:
R774
DOI:
10.13389/j.cnki.rao.2019.0087
文献标志码:
A
摘要:
视网膜感光神经节细胞(intrinsically photosensitive retinal ganglion cells,ipRGCs)是哺乳动物视网膜上一种特殊类型的神经节细胞,它能表达一种视网膜色素蛋白即黑视素蛋白,因此具备自主对光产生反应的能力。ipRGCs本质上是光敏细胞,参与成像和非成像视觉过程。本文对ipRGCs的细胞分类、信号转导、中枢投射、生理功能以及其在疾病研究中最新的研究进展进行综述。
Abstract:
Intrinsically photosensitive retinal ganglion cells (ipRGCs),a special type of ganglion cell in the mammalian retina,can express a retinal pigment protein,melanopsin,so it has the ability to autonomously respond to light.ipRGCs are essentially light-sensitive cells involved in both imaging and non-imaging visual processes.This review summarizes the cell classification,signaling,central projection,physiological functions of ipRGCs and their latest research progress in disease research.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81560168);昆明医科大学研究生创新基金资助(编号:2018S182);云南省眼科疾病研究重点实验室项目(编号:2017DG008);院士和领军人才培养项目(编号:2017HC010);院士专家工作站项目(编号:2017IC064)
更新日期/Last Update: 2019-04-15