[1]任胜卫,庞辰久,孙飒,等.新型角膜内皮镜SP-1P检测中央角膜厚度的临床应用[J].眼科新进展,2019,39(4):336-339.[doi:10.13389/j.cnki.rao.2019.0075]
　REN Sheng-Wei,PANG Chen-Jiu,SUN Sa,et al.Application of new corneal endoscope SP-1P in the measurement of central corneal thickness[J].Recent Advances in Ophthalmology,2019,39(4):336-339.[doi:10.13389/j.cnki.rao.2019.0075]
点击复制

新型角膜内皮镜SP-1P检测中央角膜厚度的临床应用/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年4期
页码:
336-339
栏目:
应用研究
出版日期:
2019-04-05

文章信息/Info

Title:
Application of new corneal endoscope SP-1P in the measurement of central corneal thickness
作者:
任胜卫; 庞辰久; 孙飒; 杨凯丽; 代丽娟; 孟志红; 鲁传琴
450003　河南省郑州市，河南省眼科研究所，河南省立眼科医院，河南省人民医院，郑州大学人民医院
Author(s):
REN Sheng-Wei; PANG Chen-Jiu; SUN Sa; YANG Kai-Li; DAI Li-Juan; MENG Zhi-Hong; LU Chuan-Qin
Henan Eye Institute & Henan Eye Hospital，Henan Provincial People’s Hospital，People’s Hospital of Zhengzhou University，Zhengzhou 450003，Henan Province，China
关键词:
中央角膜厚度; A型超声角膜测厚仪; 角膜内皮镜SP-1P; 眼前节光学相干断层扫描仪
Keywords:
central corneal thickness; type-A ultrasonic corneal thickness gauge; corneal endoscope SP-1P; anterior segment optical coherence tomography
分类号:
R778.1
DOI:
10.13389/j.cnki.rao.2019.0075
文献标志码:
A
摘要:
目的　研究角膜内皮镜SP-1P测量中央角膜厚度（central corneal thickness，CCT）的重复性，以及与A型超声角膜测厚仪（A超）和眼前节光学相干断层扫描仪（anterior segment optical coherence tomography，AS-OCT）检测CCT的一致性。方法　前瞻性临床研究。收集2017年8月至10月在河南省眼科研究所准分子激光治疗中心矫正近视的患者114例（均纳入右眼），年龄为（22.14±4.83）岁，采用角膜内皮镜SP-1P连续测量3次CCT，同时通过AS-OCT和A超分别测量CCT，测量结果采用方差分析进行比较，进一步应用Bland-Altman法对一致性进行分析。结果　角膜内皮镜SP-1P 3次测得的CCT值分别为（521.33±27.90）μm、（521.70±27.83）μm、（521.69±27.69）μm，差异无统计学意义（F=0.728，P=0.395）；Bland-Altman分析结果显示，3次测量间的差值均至少95.6%的点在95％的一致性界限内。A超及AS-OCT测得的CCT值分别为（544.50±30.48）μm和（520.75±28.62）μm，其中角膜内皮镜SP-1P和AS-OCT测得的CCT值均较A超所测CCT值偏低，差异均具有统计学意义（均为P<0.001）；而角膜内皮镜SP-1P和AS-OCT测量结果相比，差异无统计学意义（P=0.162）。结论　角膜内皮镜SP-1P测量CCT具有良好的重复性和稳定性，角膜内皮镜SP-1P和AS-OCT具有同等的准确性及良好的一致性，可以相互替代；但二者测得的CCT值均较A超偏低。
Abstract:
Objective　To investigate the repeatability of a new corneal endoscope SP-1P for central corneal thickness （CCT） measurement and further to analyze the consistency of CCT measured by corneal endoscope SP-1P，type-A ultrasonic corneal thickness gauge （A ultrasound） and anterior segment optical coherence tomography （AS-OCT）.Methods　A retrospective clinical study was performed in Henan eye institute ophthalmic excimer laser treatment center from August to October 2017.A total of 114 patients （all right eyes） aged （22.14±4.83）years old for correction of myopia were included in the current study.The CCT values of individuals were measured three times by corneal endoscope SP-1P，and were also measured by A ultrasound and AS-OCT，respectively.Analysis of variance was used to evaluate the difference，and Bland-Altman method was used to analyze the consistency.Results　The CCT values of three repeated corneal endoscope SP-1P measurements were （521.33±27.90）μm，（521.70±27.83）μm and （521.69±27.69）μm，respectively.The difference was not statistically significant among different measured methods （F=0.728，P=0.395）.The analysis of Bland-Altman showed that at least 95.6% of the differences among the three repeated measurements were within the 95% consistency limit.The CCT values measured by A ultrasound and AS-OCT were （544.50±30.48）μm and （520.75±28.62）μm，respectively.The CCT values measured by AS-OCT and corneal endoscope SP-1P were lower as comparison with measured by A ultrasound，and the differences were statistically significant （all P<0.001），but no statistically difference was obtained between the CCT values measured by AS-OCT and corneal endoscope SP-1P（P=0.162）.Conclusion　By using corneal endoscope SP-1P，the measurement of CCT had a good repeatability and stability.Furthermore，corneal endoscope SP-1P and AS-OCT have a similar accuracy and good consistency，but the CCT values were lower measured by SP-1P and AS-OCT than measured by A-ultrasound.

参考文献/References:

［1］　LACKNER B，SCHMIDINGER G，PIEH S，FUNOVICS M A，SKORPIK C.Repeatability and reproducibility of central corneal thickness measurement with Pentacam，Orbscan，and ultrasound［J］.Optom Vis Sci，2005，82（10）：892-899.
［2］　BECHMANN M，THIEL M J，NEUBAUER A S，ULLRICH S，LUDWIG K，KENYON K R.Central corneal thickness measurement with a retinal optical coherence tomography device versus standard ultrasonic pachymetry［J］.Cornea，2001，20（1）：50-54.
［3］　BLAND J M，ALTMAN D G.Statistical methods for assessing agreement between two methods of clinical measurement［J］.Lancet，1986，1（8476）：307-310.
［4］　O’DONNELL C，HARTWIG A，RADHAKRISHNAN H.Comparison of central corneal thickness and anterior chamber depth measured using LenStar LS900，Pentacam，and Visante AS-OCT［J］.Cornea，2012，31（9）：983-988.
［5］　ZHAO B，MA S J，CHEN G，WANG Y Y.Analysis of corneal thickness measured by fourier domain optical coherence tomography combined with A-scan ultrasound pachymetry and ultrasound biomicroscopy［J］.Rec Adv Ophthalmol，2013，33（7）：661-663.
赵博，马世江，陈革，王永毅.傅立叶域光学相干断层扫描、A型超声测厚仪和超声生物显微镜测量角膜厚度的相关性分析［J］.眼科新进展，2013，33（7）：661-663.
［6］　GONZALEZ-PEREZ J，QUEIRUGA PINEIRO J，SANCHEZ GARCIA ，GONZALEZ MEIJOME J M.Comparison of central corneal thickness measured by standard ultrasound pachymetry，corneal topography，tono-pachymetry and anterior segment optical coherence tomography［J］.Curr Eye Res，2018，43（7）：866-872.
［7］　GONUL S，KOKTEKIR B E，BAKBAK B，GEDIK S.Comparison of central corneal thickness measurements using optical low-coherence reflectometry，Fourier domain optical coherence tomography，and Scheimpflug camera［J］.Arq Bras Oftalmol，2014，77（6）：345-350.
［8］　IMSEK A，BILAK，GULER M，APKIN M，BILGIN B，REYHAN A H.Comparison of central corneal thickness measurements obtained by RTVue OCT，Lenstar，Sirius Topography，and Ultrasound Pachymetry in healthy subjects［J］.Semin Ophthalmol，2016，31（5）：467-472.
［9］　GOKCINAR N B，YUMUSAK E，ORNEK N，YORUBULUT S，ONARAN Z.Agreement and repeatability of central corneal thickness measurements by four different optical devices and an ultrasound pachymeter［J］.Int Ophthalmol，2018.［Epub ahead of print］.
［10］　ZHANG H H.Relationship between corneal endothelial cell changes and staging of diabetic retinopathy［J］.J Xinxiang Med Univ，2014，31（10）：842-844.
张厚洪.角膜内皮细胞变化与糖尿病性视网膜病变分期的关系［J］.新乡医学院学报，2014，31（10）：842-844.
［11］　BOVELLE R，KAUFMAN S C，THOMPSON H W，HAMANO H.Corneal thickness measurements with the Topcon SP-2000P specular microscope and an ultrasound pachymeter［J］.Arch Ophthalmol，1999，117（7）：868-870.
［12］　SUZUKI S，OSHIKA T，OKI K，SAKABE I，IWASE A，AMANO S，et al.Corneal thickness measurements：scanning-slit corneal topography and noncontact specular microscopy versus ultrasonic pachymetry［J］.J Cataract Refract Surg，2003，29（7）：1313-1318.
［13］　PENG H Y，PANG C J，WANG Y F，KONG Z，WANG L Y.Comparative study of central corneal and midperipheral corneal thickness measurements with specular microscopy，Slit-scanning pachymetry，anterior segment optical coherence tomography and ultrasound pachymetry［J］.Chin J Pract Ophthalmol，2012，30（8）：936-940.
彭海英，庞辰久，王英飞，孔众，王丽娅.角膜内皮镜Orbscan Ⅱ眼前节OCT及超声法测量角膜中央及旁中央厚度的比较研究［J］.中国实用眼科杂志，2012，30（8）：936-940.

相似文献/References:

[1]周琼 黄敬.盐酸丙美卡因滴眼液对兔眼中央角膜厚度及角膜上皮形态学的影响[J].眼科新进展,2012,32(7):000.
[2]汤勇 刘才远.LASIK、Epi-LASIK、SBK、Fem-LASIK及SMILE术中角膜切削误差的对比研究[J].眼科新进展,2013,33(9):000.
[3]孙宏霞 陶晨雯 刘苏冰 聂晓丽 买志彬 辛宝莉.四种方法测量近视患者中央角膜厚度的比较研究[J].眼科新进展,2012,32(9):000.
[4]郑江娉 廖敏华.不同手术方式对高度近视合并白内障患者中央角膜厚度及视觉质量的影响[J].眼科新进展,2013,33(10):000.
[5]张亦农. 抗青光眼术后中央角膜厚度变化及其与眼压的相关性研究[J].眼科新进展,2014,34(3):251.
[6]孙倩,周跃华.远视眼与近视眼角膜生物力学研究及眼压的比较[J].眼科新进展,2014,34(10):971.[doi:10.13389/j.cnki.rao.2014.0269]
[7]郑彪,蔡艳霞,柯毅. 不同类型青光眼患者前部巩膜厚度与眼部生物学参数的相关性研究[J].眼科新进展,2015,35(2):177.[doi:10.13389/j.cnki.rao.2015.0048]
　ZHENG Biao,CAI Yan-Xia,KE Yi.Correlation between anterior sclera thickness and other ocular biological parameters in patients with different types of glaucoma[J].Recent Advances in Ophthalmology,2015,35(4):177.[doi:10.13389/j.cnki.rao.2015.0048]
[8]王明玥,肖伟,濮伟,等.婴儿先天性白内障摘出术后早期中央角膜厚度变化与眼压的相关性研究[J].眼科新进展,2015,35(10):931.[doi:10.13389/j.cnki.rao.2015.0254]
　WANG Ming-Yue,XIAO Wei,PU Wei,et al.Central corneal thickness changes of infantal congenital cataracts and its correlation with intraocular pressure following extraction surgery[J].Recent Advances in Ophthalmology,2015,35(4):931.[doi:10.13389/j.cnki.rao.2015.0254]
[9]毕文娇,吴洁,刘坤,等.Tomey OA-2000、IOL Master 700及 A 超角膜测厚仪测量近视患者中央角膜厚度的比较[J].眼科新进展,2019,39(8):776.[doi:10.13389/j.cnki.rao.2019.0177]
　BI Wen-Jiao,WU Jie,LIU Kun,et al.Comparison of central corneal thickness measured by Tomey OA-2000,IOL Master 700 and A ultrasound pachymetry in myopic eyes[J].Recent Advances in Ophthalmology,2019,39(4):776.[doi:10.13389/j.cnki.rao.2019.0177]
[10]徐畅,宋籽浔,王明玥,等.白内障摘出联合人工晶状体（IOL）植入术及无晶状体眼行IOL二期植入术患儿术后眼前节结构特点[J].眼科新进展,2019,39(10):929.[doi:10.13389/j.cnki.rao.2019.0211]
　XU Chang,SONG Zi-Xun,WANG Ming-Yue,et al.Anterior segmental biometry characteristics of children patients following cataract extraction combined with intraocular lens (IOL) implantation or secondary IOL implantation in aphakic eyes[J].Recent Advances in Ophthalmology,2019,39(4):929.[doi:10.13389/j.cnki.rao.2019.0211]

备注/Memo

备注/Memo:
国家自然科学基金青年科学基金项目（编号：81200664）；河南省自然科学基金（编号：182300410362）；河南省科技厅基础与前沿项目（编号：162300410235）
更新日期/Last Update: 2019-04-15