[1]张敏,李志坚,王亚敏.细胞焦亡在眼部疾病中的研究进展[J].眼科新进展,2019,39(1):082-85.[doi:10.13389/j.cnki.rao.2019.0019]
　ZHANG Min,LI Zhi-Jian,WANG Ya-Min.Research progress of pyroptosis in ocular diseases[J].Recent Advances in Ophthalmology,2019,39(1):082-85.[doi:10.13389/j.cnki.rao.2019.0019]
点击复制

细胞焦亡在眼部疾病中的研究进展/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年1期
页码:
082-85
栏目:
文献综述
出版日期:
2019-01-05

文章信息/Info

Title:
Research progress of pyroptosis in ocular diseases
作者:
张敏; 李志坚; 王亚敏
150001　黑龙江省哈尔滨市，哈尔滨医科大学附属第一医院眼科医院
Author(s):
ZHANG Min; LI Zhi-Jian; WANG Ya-Min
Eye Hospital，the First Affiliated Hospital of Harbin Medical University，Harbin 150001，Heilongjiang Province，China
关键词:
细胞焦亡; 老年性黄斑变性; 角膜炎; 白内障
Keywords:
pyroptosis; age-related macular degeneration; keratitis; cataract
分类号:
R77
DOI:
10.13389/j.cnki.rao.2019.0019
文献标志码:
A
摘要:
细胞焦亡与细胞凋亡、细胞坏死及自噬不同，是一种程序性促炎性细胞死亡方式。其主要信号通路包括依赖caspase-1的经典焦亡途径和依赖caspase-4/5、caspase-11的非经典焦亡途径。已有大量研究表明，细胞焦亡与感染性疾病、动脉粥样硬化性疾病、代谢性疾病及重要脏器非细菌性炎性疾病相关。近几年细胞焦亡在眼部疾病中也有部分研究，包括老年性黄斑变性、角膜炎、白内障等疾病。本文主要综述细胞焦亡的主要机制及其在眼部疾病中的研究进展。
Abstract:
Pyroptosis is a programmed pro-inflammatory cell death mode which different from apoptosis，necrosis and autophagy.The main signaling pathways include classic caspase-1-dependent pyroptosis and non-classical caspase-4/5-dependent and caspase-11 dependent pyroptosis.A large number of studies have shown that pyroptosis is associated with infectious diseases，atherosclerotic diseases，metabolic diseases and important non-bacterial inflammatory diseases of organs.In recent years，pyroptosis has been studied in some eye disease，including age-related macular degeneration，keratitis，cataract and other diseases.The main mechanism of pyroptosis and its progress in ocular diseases will be reviewed in this paper.

参考文献/References:

［1］　FINK S L，COOKSON B T.Apoptosis，pyroptosis，and necrosis：mechanistic description of dead and dying eukaryotic cells［J］.Infect Immun，2005，73（4）：1907-1916.
［2］　BERGSBAKEN T，FINK S L，COOKSON B T.Pyroptosis：host cell death and inflammation［J］.Nat Rev Microbiol，2009，7（2）：99-109.
［3］　CHEN X，HE W T，HU L，LI J，FANG Y，WANG X，et al.Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis［J］.Cell Res，2016，26（9）：1007-1020.
［4］　MAN S M，KANNEGANTI T D.Gasdermin D：the long-awaited executioner of pyroptosis［J］.Cell Res，2015，25（11）：1183-1184.
［5］　BROZ P.Immunology：Caspase target drives pyroptosis［J］.Nature，2015，526（7575）：642-643.
［6］　MARTINON F，BURNS K，TSCHOPP J.The inflammasome：a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta［J］.Mol Cell，2002，10（2）：417-426.
［7］　DING J，WANG K，LIU W，SHE Y，SUN Q，SHI J，et al.Erratum：Pore-forming activity and structural autoinhibition of the gasdermin family［J］.Nature，2016，535（7610）：111-116.
［8］　LIU X，ZHANG Z，RUAN J，PAN Y，MAGUPALLI V G，WU H，et al.Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores［J］.Nature，2016，535（7610）：153-158.
［9］　DUNAIEF J L，DENTCHEV T，YING G S，MILAM AH.The role of apoptosis in age-related macular degeneration［J］.Arch Ophthalmol，2002，120（11）：1435-1442.
［10］　AMBATI J，AMBATI B K，Yoo S H，LANCHULEV S，ADAMIS A P.Age-related macular degeneration：etiology，pathogenesis，and therapeutic strategies［J］.Surv Ophthalmol，2003，48（3）：257-293.
［11］　AMOAKU W M，CHAKRAVARTHY U，GALE R，GAVIN M，CHANCHI F，GIBSON J，et al.Defining response to anti-VEGF therapies in neovascular AMD［J］.Eye （Lond），2015，29（6）：721-731.
［12］　SINGH M，TYAGI S C.Hyperhomocysteinemia and age-related macular degeneration：role of inflammatory mediators and pyroptosis：a Proposal［J］.Med Hypotheses，2017，105：17-21.
［13］　CHEN S，SHEN D，POPP N A，OGILVY A J，TUO J，ABU-ASAB M，et al.Responses of Multipotent Retinal Stem Cells to IL-1β，IL-18，or IL-17［J］.J Ophthalmol，2015，2015：369312.
［14］　GAO J，CUI J Z，TO E，CAO S，MATSUBARA J A.Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye［J］.J Neuroinflammat，2018，15（1）：15.
［15］　VIRINGIPURAMPEER I A，METCALFE A L，BASHAR A E，SIVAK O，YANAI A，MOHAMMADI Z，et al.NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration［J］.Hum Mol Genet，2016，25（8）：1501-1516.
［16］　TSENG W A，THEIN T，KINNUNEN K，LASHKARI K，GREGORY M S，D’AMORE，P A，et al.NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization：implications for age-related macular degeneration［J］.Invest Ophthalmol Vis Sci，2013，54（1）：110-120.
［17］　BRANDSTETTER C，PATT J，HOLZ F G，KROHNE T U.Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis［J］.J Photochem Photobiol B，2016，161：177-183.
［18］　JIN X，JIN H，SHI Y，GUO Y，ZHANG H.Pyroptosis，a novel mechanism implicated in cataracts［J］.Mol Med Rep，2018，18（2）：2277-2285.
［19］　JIN X，JIN H，SHI Y，GUO Y，ZHANG H.Long non-coding RNA KCNQ1OT1 promotes cataractogenesis via miR-214 and activation of the caspase-1 pathway［J］.Cell Physiol Biochem，2017，42（1）：295-305.
［20］　QU W，WANG Y，WU Y，LIU Y，CHEN K，ZOU Z，et al.Triggering receptors expressed on myeloid cells 2 promotes corneal resistance against by inhibiting caspase-1-dependent pyroptosis［J］.Front Immunol，2018，9：1121.
［21］　BRICKER-ANTHONY C，HINES-BEARD J，REX TS.Molecular changes and vision loss in a mouse model of closed-globe blast trauma［J］.Invest Ophthalmol Vis Sci，2014，55（8）：4853-4862.
［22］　KIM L A，AMARNANI D，GNANAGURU G，TSENG W A，VAVVAS D G，D’AMORE，P A.Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms［J］.Invest Ophthalmol Vis Sci，2014，55（8）：4747-4758.

相似文献/References:

[1]周尚昆 唐由之 冯俊 陈有信 戴虹 王慧娟. 明睛颗粒治疗湿性老年性黄斑变性的临床研究[J].眼科新进展,2014,34(2):155.
[2]刘雪莲,白宁艳,李治清,等.视网膜脉络膜深层扫描在老年性黄斑变性患者诊断中的作用[J].眼科新进展,2015,35(10):952.[doi:10.13389/j.cnki.rao.2015.0259]
　LIU Xue-Lian,BAI Ning-Yan,LI Zhi-Qing,et al.Role of retinal choroidal deep scan in diagnosis of age-related macular degeneration[J].Recent Advances in Ophthalmology,2015,35(1):952.[doi:10.13389/j.cnki.rao.2015.0259]
[3]吴若欣,徐洁慧,温积全,等.玻璃体内注射康柏西普对渗出性老年性黄斑变性患者脉络膜厚度的影响[J].眼科新进展,2016,36(12):1172.[doi:10.13389/j.cnki.rao.2016.0312]
　WU Ruo-Xin,XU Jie-Hui,WEN Ji-Quan,et al.Effects of intravitreal conbercept injections on choroidal thickness in exudative age-related macular degeneration[J].Recent Advances in Ophthalmology,2016,36(1):1172.[doi:10.13389/j.cnki.rao.2016.0312]
[4]郝义,孙笑,刘玉秋,等.miRNA-146a在视网膜色素上皮细胞老化及老年性黄斑变性中的功能研究[J].眼科新进展,2017,37(2):117.[doi:10.13389/j.cnki.rao.2017.0031]
　HAO Yi,SUN Xiao,LIU Yu-Qiu,et al.Function of miR-146a in retinal pigment epithelial cells aging and age-related macular degeneration[J].Recent Advances in Ophthalmology,2017,37(1):117.[doi:10.13389/j.cnki.rao.2017.0031]
[5]赵永吉,丁秋爱,游志鹏.老年性黄斑变性免疫炎症机制的研究进展[J].眼科新进展,2017,37(11):1079.[doi:10.13389/j.cnki.rao.2017.0273]
　ZHAO Yong-Ji,DING Qiu-Ai,YOU Zhi-Peng.Advance in immune and inflammatory mechanisms of age-related macular degeneration[J].Recent Advances in Ophthalmology,2017,37(1):1079.[doi:10.13389/j.cnki.rao.2017.0273]
[6]黄定国,岑令平,张安琳,等.频域光学相干断层扫描观察康柏西普治疗老年性黄斑变性患者黄斑结构的变化[J].眼科新进展,2018,38(12):1157.[doi:10.13389/j.cnki.rao.2018.0273]
　HUANG Ding-Guo,CEN Ling-Ping,ZHANG An-Lin,et al.Changes in macular structure after treatment with conbercept for age-related macular degeneration by spectral domain optical coherence tomography[J].Recent Advances in Ophthalmology,2018,38(1):1157.[doi:10.13389/j.cnki.rao.2018.0273]
[7]黄晓旭,苏荣健,刘华.青蒿素对过氧化氢诱导的人视网膜色素上皮（RPE）细胞氧化应激损伤的抑制作用[J].眼科新进展,2019,39(4):306.[doi:10.13389/j.cnki.rao.2019.0069]
　HUANG Xiao-Xu,SU Rong-Jian,LIU Hua.Inhibition of Artemisinin on oxidative stress injury induced by hydrogen peroxide in human retinal pigment epithelium cells[J].Recent Advances in Ophthalmology,2019,39(1):306.[doi:10.13389/j.cnki.rao.2019.0069]
[8]朱美江,任成达,蔡雯婷,等.外周血液中miRNA表达与老年性黄斑变性相关性研究[J].眼科新进展,2019,39(7):677.[doi:10.13389/j.cnki.rao.2019.0156]
　ZHU Mei-Jiang,REN Cheng-Da,CAI Wen-Ting,et al.Correlation between the expression of circulating miRNAs and age-related macular degeneration[J].Recent Advances in Ophthalmology,2019,39(1):677.[doi:10.13389/j.cnki.rao.2019.0156]
[9]冯绮婷,梁瑜钦,黄雄飞,等.P-糖蛋白对H2O2诱导的视网膜色素上皮细胞氧化损伤的抑制作用[J].眼科新进展,2020,40(10):915.[doi:10.13389/j.cnki.rao.2020.0206]
　FENG Qiting,LIANG Yuqin,HUANG Xiongfei,et al.Inhibition effect of P-glycoprotein functional expression on oxidative damage of retinal pigment epithelial cells[J].Recent Advances in Ophthalmology,2020,40(1):915.[doi:10.13389/j.cnki.rao.2020.0206]
[10]崔俊,崔仁哲,刘熙文,等.艾塞那肽对4-羟基壬烯醛诱导人视网膜色素上皮细胞氧化应激损伤的抑制作用[J].眼科新进展,2020,40(11):1001.[doi:10.13389/j.cnki.rao.2020.0224]
　CUI Jun,CUI Renzhe,LIU Xiwen,et al.Inhibitory effect of exendin-4 on oxidative stress injury induced by 4-HNE in human retinal pigment epithelium cells[J].Recent Advances in Ophthalmology,2020,40(1):1001.[doi:10.13389/j.cnki.rao.2020.0224]

备注/Memo

备注/Memo:
国家自然科学基金面上项目（编号：81870643）
更新日期/Last Update: 2019-01-04