[1]王蕾,陶天畅,崇伟华,等.先天性视锥视杆细胞营养不良症患者血清脂质浓度的变化[J].眼科新进展,2018,38(7):647-650.[doi:10.13389/j.cnki.rao.2018.0152]
　WANG Lei,TAO Tian-Chang,CHONG Wei-Hua,et al.Changes in the serum lipids of patients with congenital cone-rod dystrophy[J].Recent Advances in Ophthalmology,2018,38(7):647-650.[doi:10.13389/j.cnki.rao.2018.0152]
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年7期
页码:
647-650
栏目:
应用研究
出版日期:
2018-07-05

文章信息/Info

Title:
Changes in the serum lipids of patients with congenital cone-rod dystrophy
作者:
王蕾; 陶天畅; 崇伟华; 李根林
100730　北京市，首都医科大学附属北京同仁医院，北京同仁眼科中心，北京市眼科学与视觉科学重点实验室
Author(s):
WANG Lei; TAO Tian-Chang; CHONG Wei-Hua; LI Gen-Lin
Beijing Tongren Eye Center，Beijing Tongren Hospital，Capital Medical University，Beijing Ophthalmology & Visual Science Key Laboratory，Beijing 100730，China
关键词:
视锥视杆细胞营养不良; 血清浓度水平; 低密度脂蛋白胆固醇; 高密度脂蛋白胆固醇; 甘油三酯; 总胆固醇
Keywords:
cone-rod dystrophy; serum concentration level; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; triglycerides; total cholesterol
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2018.0152
文献标志码:
A
摘要:
目的　分析先天性视锥视杆细胞营养不良症（cone-rod dystrophy，CORD）患者血清脂质浓度变化情况。方法　采用回顾性序列病例研究方法，选取临床诊断为CORD的患者50例作为CORD组，选取52位正常人作为正常对照组，按盲法由专业技术人员测量两组血清中低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C）、甘油三酯（triglycerides，TG）、总胆固醇（total cholesterol，TC）含量，并对两组测量结果进行比较，分析CORD患者体内血清脂质浓度的变化情况。结果　50例CORD患者中血脂水平异常者占48.00%，其中高TG血症者占54.17%，高TC血症者占12.50%，混合型高脂血症者占25.00%，低HDL-C血症者占8.33%。CORD患者中血清TG浓度［（1.874±1.745）mmol·L-1］和TC浓度［（4.719±0.746）mmol·L-1］与正常对照组［（0.848±0.316）mmol·L-1］和［（4.098±0.596）mmol·L-1］相比均显著升高，差异均有统计学意义（t=-4.171、-4.657，均为P=0.000）；HDL-C浓度［（1.138±0.290）mmol·L-1］与正常对照组［（1.386±0.226）mmol·L-1］相比显著下降，差异均有统计学意义（t=4.817，P=0.000）；LDL-C浓度［（2.579±0.541）mmol·L-1］与正常对照组［（2.408±0.551）mmol·L-1］相比差异无统计学意义（t=-1.584，P=0.116）。结论　CORD患者血清TG和TC浓度升高、HDL-C浓度降低，这可能与CORD的发病相关。
Abstract:
Objective　To analyze the serum lipids changes in patients with cone-rod dystrophy.Methods　A retrospective sequence case study was conducted in 50 patients with congenital cone-rod dystrophy （CORD） who were selected as the CORD group and 52 normal subjects as the normal group.The serum levels of low density lipoprotein cholesterol （LDL-C），high density lipoprotein cholesterol （HDL-C），triglycerides （TG） and total cholesterol （TC） were measured by professional technicians in hospital according to the single blind study.Data were analyzed statistically between the CORD group and normal group.Results　Among the 50 patients with CORD，48.00% had abnormal blood lipid levels，of whom 54.17% were hypertrichonemia，12.50% were hypercholesterolemia，25.00% were mixed hyperlipidaemia，and low HDL-C accounted for 8.33%，respectively.The serum concentrations of TG and TC were（1.874±1.745）mmol·L-1 and （4.719±0.746）mmol·L-1 in the CORD group，which were significantly higher than those of the normal group［（0.848±0.316）mmol·L-1 and （4.098±0.596）mmol·L-1］（t=-4.171，-4.657，both P=0.000），but the serum level of HDL-C was（1.138±0.290）mmol·L-1 in the CORD group，which was significantly lower than that of the normal group［（1.386±0.226）mmol·L-1］（t=4.817，P=0.000）.There was no significant difference in the serum level of LDL-C between CORD and normal group［（2.579±0.541）mmol·L-1 vs.（2.408±0.551）mmol·L-1］（t=-1.584，P=0.116）.Conclusion　Elevated serum concentrations of TG and TC，and decreased HDL-C level in CORD patients may be associated with the development of CORD.

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相似文献/References:

[1]陶天畅,王蕾,崇伟华,等.视锥视杆细胞营养不良患者脉络膜和视网膜血流的异常变化[J].眼科新进展,2018,38(5):444.[doi:10.13389/j.cnki.rao.2018.0103]
　TAO Tian-Chang,WANG Lei,CHONG Wei-Hua,et al.The anomalies of choroidal and retinal blood flow in cone-rod dystrophy[J].Recent Advances in Ophthalmology,2018,38(7):444.[doi:10.13389/j.cnki.rao.2018.0103]

备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81271046）；北京市自然科学基金项目暨北京市教育委员会科技发展计划重点项目（编号：KZ201510025025）
更新日期/Last Update: 2018-07-12