[1]李海东,毛剑波,程丹,等.2型糖尿病患者平均血小板体积与糖尿病黄斑水肿的关系[J].眼科新进展,2018,38(6):576-578.[doi:10.13389/j.cnki.rao.2018.0136]
　LI Hai-Dong,MAO Jian-Bo,CHENG Dan,et al.Correlation of mean platelet volume with diabetic macular edema in type 2 diabetic patients[J].Recent Advances in Ophthalmology,2018,38(6):576-578.[doi:10.13389/j.cnki.rao.2018.0136]
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2型糖尿病患者平均血小板体积与糖尿病黄斑水肿的关系/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年6期
页码:
576-578
栏目:
应用研究
出版日期:
2018-06-05

文章信息/Info

Title:
Correlation of mean platelet volume with diabetic macular edema in type 2 diabetic patients
作者:
李海东; 毛剑波; 程丹; 沈洁; 沈丽君
310020　浙江省杭州市，温州医科大学附属眼视光医院杭州院区
Author(s):
LI Hai-Dong; MAO Jian-Bo; CHENG Dan; SHEN Jie; SHEN Li-Jun
Eye Hospital of Wenzhou Medical University at Hangzhou，Hangzhou 310020，Zhejiang Province，China
关键词:
血小板参数; 平均血小板体积; 血小板平均分布宽度; 黄斑水肿; 2型糖尿病
Keywords:
platelet parameters;  mean platelet volume;  platelet distribution width;  macular edema;  type 2 diabetes mellitus
分类号:
R774.5
DOI:
10.13389/j.cnki.rao.2018.0136
文献标志码:
A
摘要:
目的　探讨2型糖尿病患者平均血小板体积（mean platelet volume，MPV）与糖尿病性黄斑水肿（diabetic macular edema，DME）的关系。方法　本研究共有四组患者，分别是健康对照组（组1，n=40例）、有糖尿病无糖尿病视网膜病变（diabetic retinopathy，DR）组（组2，n=40例）、有DR无DME组（组3，n=40例）和DR伴DME组（组4，n=40例），采集患者一般信息，散瞳眼底彩照和OCT检查，检测外周血血小板4参数：血小板计数（platelet count，PLT）、MPV、血小板平均分布宽度（platelet distribution width，PDW）和血小板压积（plateletcrit，PCT）。比较4组患者PLT、MPV、PDW和PCT。结果　四组间MPV和PDW差异均有统计学意义（均为P<0.05），而PLT和PCT差异均无统计学意义（均为P>0.05）。组间比较MPV和PDW显示，组3［（11.07±1.06）fL、（13.57±2.25）fL］和组4［（11.27±0.85）fL、（13.89±1.76）fL］分别均高于组1［（10.41±0.63）fL、（11.93±1.22）fL］和组2［（10.38±0.51）fL、（12.33±1.28）fL］（均为P<0.05）。组4的MPV和PDW均高于组3，但差异均无统计学意义（P=0.254、0.388）。男性患者MPV组间比较显示，组2（10.29±0.58）fL、组3（10.67±1.08）fL和组4（11.42±0.90）fL逐渐增大（P<0.05），而组1（10.27±0.55）fL和组2间差异无统计学意义（P>0.05）。女性患者MPV组间比较显示，组3（11.37±0.69）fL和组4（11.13±0.79）fL分别均高于组1（10.55±0.70）fL和组2（10.42±0.49）fL（均为P<0.05），组3和组4间差异无统计学意义（P>0.05）。结论　MPV升高可能是2型糖尿病DR患者发生DME的一个重要危险因素，监测血小板参数有助于DR病情监控。
Abstract:
Objective　To investigate the relationship between mean platelet volume （MPV） and diabetic macular edema （DME） in type 2 diabetic patients.Methods　The study included 4 patient groups：40 healthy control as group 1，40 diabetic patients without diabetic retinopathy（DR） as group 2，40 DR patients without DME as group 3，and 40 DR patients with DME as group 4.Then the collection of general information，fundus photograph and OCT were conducted for the measurement and comparison of serum levels of platelet parameters including platelet count （PLT），MPV，platelet distribution width （PDW） and plateletcrit （PCT）.Results　Significant differences were found in MPV and PDW among the four groups （all P<0.05），but there was no significant difference in PLT and PCT levels （all P<0.05）.Furthermore，MPV and PDW level was （11.07±1.06）fL and （13.57±2.25）fL in group 3，as well as （11.27±0.85）fL and （13.89±1.76）fL in group 4，respectively，which were both significantly higher than those in group 1 ［（10.41±0.63）fL and （11.93±1.22）fL］ as well as in group 2 ［（10.38±0.51）fL and （12.33±1.28）fL］ （all P<0.05）.Both MPV and PDW levels of group 4 were higher than those of group 3，but there was no significant difference （P=0.254，0.388）.As for males，MPV level was increased gradually in group 2 ［（10.29±0.58）fL］，group 3 ［（10.67±1.08）fL］ and group 4 ［（11.42±0.90）fL］（all P<0.05），but there was no significant difference between group 1 ［（10.27±0.55）fL］ and group 2.For females，MPV level was （11.37±0.69）fL in group 3 and （11.13±0.79）fL in group 4，both which were significantly higher than that in group 1 ［（10.55±0.70）fL］ and group 2 ［（10.42±0.49）fL］，respectively （all P<0.05），but there was no significant difference between group 3 and group 4 （P>0.05）.Conclusion　High MPV level may be an important risk factor for the development of DME in DR patients.Platelet parameter surveillance can aid in the monitoring of this disease.

参考文献/References:

［1］　XU X，ZHENG Y.Focusing on the treatment of diabetic macular edema［J］.Chin J Ocul Fundus Dis，2016，32（2）：119-121.
许迅，郑颖.重视对糖尿病黄斑水肿的治疗［J］.中华眼底病杂志，2016，32（2）：119-121.
［2］　PRAIDOU A，PAPAKONSTANTINOU E，ANDROUDI S，GEORGIADIS N，KARAKIULAKIS G，DIMITRAKOS S.Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in patients with non-proliferative diabetic retinopathy and clinically significant macula oedema［J］.Acta Ophthalmol，2011，89（3）：248-254.
［3］　BO Q Y，ZHANG Y，WU Y W，WANG F.Research advances of platelet derived growth factor family and its significance in neovascular eye［J］.Chin J Ophthalmol，2014，50（6）：471-475.
［4］　CITIRIK M，BEYAZYILDIZ E，SIMSEK M，BEYAZYILDIZ O，HAZNEDAROGLU I C.MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy［J］.Eye （Lond），2015，29（3）：376-379.
［5］　DEMIRTAS L，DEGIRMENCI H，AKBAS E M，OZCICEK A，TIMUROGLU A，GUREL A，et al.Association of hematological indicies with diabetes，impaired glucose regulation and microvascular complications of diabetes［J］.Int J Clin Exp Med，2015，8（7）：11420-11427.
［6］　Chinese Diabetes Society.Chinese guidelines for the management of type 2 diabetesmellitus（2013）［J］.Chin J Diabet Mell，2014，6（7）：447-498.
中华医学会糖尿病学分会.中国2型糖尿病防治指南（2013年版）［J］.中华糖尿病杂志，2014，6（7）：447-498.
［7］　Academic Group of Fundus Diseases in Chinese Ophthalmological Society.Chinese clinical managementguidelines for diabeticretinopathy（2014）［J］.Chin J Ophthalmol，2014，50（11）：851-865.
中华医学会眼科学会眼底病学组.我国糖尿病视网膜病变临床诊疗指南（2014年）［J］.中华眼科杂志，2014，50（11）：851-865.
［8］　AYHAN TUZCU E，ARICA S，LLHAN N，DAGLIOGLU M，COSKUN M，LLHAN O，et al.Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes mellitus［J］.Graefes Arch Clin Exp Ophthalmol，2014，252（2）：237-240.
［9］　MA F F，ZHANG Y X.Changes and clinical significance of platelet activation and four platelet parameters in diabetic retinopathy［J］.Rec Adv Ophthalmol，2017，37（2）：164-171.
马芳芳，张奕霞.血小板活化因子及血小板四参数在糖尿病视网膜病变中的变化及临床意义［J］.眼科新进展，2017，37（2）：164-171.
［10］　GUNGOR A A，GURSOY G，GUNGOR F，BAYRAM S M，ATALAY E.The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus［J］.Turk J Med Sci，2016，46（5）：1292-1299.
［11］　KIM M，KIM Y，LEE S J.Comparison of aqueous concentrations of angiogenic and inflammatory cytokines based on optical coherence tomography patterns of diabetic macular edema［J］.Indian J Ophthalmol，2015，63（4）：312-317.
［12］　MA F，ZHANG L J，SUN H，HAO Y M，ZHANG Y J.Investigation of platelet parameters of healthy adults in the northern area of Anhui province［J］.J Bengbu Med Coll，2012，37（12）：1522-1524.
马芳，张伦军，孙红，郝艳梅，张英杰.皖北地区健康成人血小板相关参数的调查［J］.蚌埠医学院学报，2012，37（12）：1522-1524.

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更新日期/Last Update: 2018-07-10