[1]王蕾,李根林.神经元-胶质细胞共生体系对神经营养因子活性影响的研究现状[J].眼科新进展,2018,38(4):389-392.[doi:10.13389/j.cnki.rao.2018.0091]
　WANG Lei,LI Gen-Lin.Research status of neuronal-glial cell symbiosis system on neurotrophic factor activity[J].Recent Advances in Ophthalmology,2018,38(4):389-392.[doi:10.13389/j.cnki.rao.2018.0091]
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神经元-胶质细胞共生体系对神经营养因子活性影响的研究现状/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年4期
页码:
389-392
栏目:
文献综述
出版日期:
2018-04-05

文章信息/Info

Title:
Research status of neuronal-glial cell symbiosis system on neurotrophic factor activity
作者:
王蕾; 李根林
100730　北京市，首都医科大学附属北京同仁医院，北京同仁眼科中心，北京市眼科学与视觉科学重点实验室
Author(s):
WANG Lei; LI Gen-Lin
Beijing Tongren Eye Center，Beijing Tongren Hospital，Capital Medical University，Beijing Ophthalmology & Visual Sciences Key Laboratory，Beijing 100730，China
关键词:
视网膜色素变性; 神经元-胶质细胞共生体系; 脑源性神经营养因子; 睫状神经营养因子; 胶质细胞源性神经营养因子
Keywords:
retinitis pigmentosa; neuronal-glial cell symbiosis system; brain-derived neurotrophic factors; ciliary neurotrophic factors; glial cell line-derived neurotrophic factors
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2018.0091
文献标志码:
A
摘要:
视网膜色素变性的病理特点是感光细胞和视网膜色素上皮细胞结构和功能的进行性丧失。神经营养因子对其保护作用越来越受到关注。脑源性神经营养因子、睫状神经营养因子和胶质细胞源性神经营养因子可通过直接和间接保护通路影响感光细胞活性。而神经元-胶质细胞共生体系介导的对感光细胞活性的间接保护作用更为重要。胶质细胞介导的神经营养因子治疗相关眼病取得了部分进展，这将为延缓视网膜色素变性病情发展提供一种新的有效手段。
Abstract:
Retinitis pigmentosa is characterized by the progressive loss of the structure and function of photoreceptors and retinal pigment epithelium.Neurotrophic factors are more and more concerned.Brain-derived neurotrophic factors，ciliary neurotrophic factors and glial cell line-derived neurotrophic factors can affect photoreceptor activity through direct and indirect protection pathways.Neuronal-glial cell symbiosis system mediated by the indirect protection of photoreceptors is more important.Studies on glial cell-mediated neurotrophic factors for the treatment of related eye disease have made some progress，which will provide a new and effective methodsto delay the development of RP.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81271046）；北京市自然科学基金项目暨北京市教育委员会科技发展计划重点项目（编号：KZ201510025025）
更新日期/Last Update: 2018-04-02