[1]郑彪,彭红娟,柯毅,等.视盘水肿患者视盘周围区域厚度参数的改变[J].眼科新进展,2017,37(11):1057-1059.[doi:10.13389/j.cnki.rao.2017.0267]
　ZHENG Biao,PENG Hong-Juan,KE Yi,et al.Changes in circumpapillary thickness parameters measured by optical coherence tomography in patients with optic disc edema[J].Recent Advances in Ophthalmology,2017,37(11):1057-1059.[doi:10.13389/j.cnki.rao.2017.0267]
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视盘水肿患者视盘周围区域厚度参数的改变/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年11期
页码:
1057-1059
栏目:
应用研究
出版日期:
2017-11-05

文章信息/Info

Title:
Changes in circumpapillary thickness parameters measured by optical coherence tomography in patients with optic disc edema
作者:
郑彪; 彭红娟; 柯毅; 方林彬; 黎宗汉
524001　广东省湛江市，广东医科大学附属医院眼科
Author(s):
ZHENG Biao; PENG Hong-Juan; KE Yi; FANG Lin-Bin; LI Zong-Han
Department of Ophthalmology,Affiliated Hospital of Guangdong Medical University，Zhanjiang 524001，Guangdong Province，China
关键词:
光学相干断层扫描; 视盘水肿; 视盘周围区域厚度参数; 视网膜神经纤维厚度; 视盘周围视网膜总厚度
Keywords:
optical coherence tomography; optic disc edema; circumpapillary thickness parameters; circumpapillary retinal nerve fiber layer thickness; circumpapillary total retinal thickness
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2017.0267
文献标志码:
A
摘要:
目的　采用光学相干断层扫描（optical coherence tomography，OCT） 观察视盘水肿患者视盘周围区域厚度参数的改变，为视盘水肿的临床评估寻找新方法。方法　选取2012年10月至2015年10月在我院门诊就诊和住院的视盘水肿患者36例（36眼）作为研究对象，同时选取在我院体检的无眼科疾病的正常人51人（51眼）作为对照组。所有研究对象均检测视力、裂隙灯、眼底及眼底照相，全部研究眼均行OCT扫描检测视盘周围视网膜神经纤维厚度（circumpapillary retinal nerve fiber layer thickness，cpRNFLT）及视盘周围视网膜总厚度（circumpapillary total retinal thickness，cpTRT）。结果　本研究选取的36例视盘水肿患者中轻度5例，中度15例，重度16例。OCT扫描后，连续检查3次均不能获得满意图像或计算机无法正确分析者将被剔除，最后有25例视盘水肿患者（轻度5例，中度14例，重度6例）符合分析cpRNFLT的要求；30例视盘水肿患者（轻度5例，中度15例，重度10例）符合分析cpTRT的要求；对照组有50人符合条件纳入研究。两组受试者年龄以及性别构成差异均无统计学意义（均为P>0.05）。OCT视网膜断面图显示视盘水肿组cpRNFLT及cpTRT光带明显增宽，神经纤维层下无反射区宽度增加；视盘水肿组患者的平均及各象限cpRNFLT明显增厚，cpRNFLT以上方增厚最明显，其次是下方，然后是鼻侧和颞侧，与对照组相比差异均有统计学意义（均为P<0.001）。OCT检查结果显示，视盘水肿组患者平均及各象限cpTRT明显增厚，cpTRT以下方增厚最明显，其次是上方，然后是鼻侧和颞侧，与对照组相比差异亦均有统计学意义（均为P<0.001）。结论　视盘水肿患者视盘周围区域厚度参数均较正常人明显增厚，这些参数可作为视盘水肿诊断以及研究的参考指标。
Abstract:
Objective　To observe the changes in the circumpapillary thickness parameters measured by optical coherence tomography(OCT) in patients with optic disc edema (ODE).Methods　Together 36 patients (36 eyes) diagnosed with ODE from October 2012 to October 2015 were included in the study，and 51 age-and gender-matched control subjects (51 eyes) were recruited from among healthy individuals with no history or evidence of current ocular disease.All the subjects were examined for visual acuity，slit lamp，fundus and fundus photography，and all the eyes underwent OCT scan to detect the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and circumpapillary total retinal thickness (cpTRT).Results　After OCT scan，25 ODE patients (5 mild，14 moderate and 6 severe patients) and 30 patients (5 mild，15 moderate and 10 severe patients) were in line with the requirements of cpRNFLT analysis and cpTRT analysis respectively；there were 50 controls meeting the requirements of this study.There was no significant difference in age and sex between ODE patients and the controls (all P>0.05).The mean cpRNFLT and cpRNFLT in each quadrant of ODE patients were significantly thickened than those of controls，and the superior cpRNFLT was the thickest，followed by the inferior，then the nasal and temporal cpRNFLT，and the difference was statistically significant (P<0.001).The mean cpTRT and cpTRT in each quadrant of ODE patients were significantly thickened than those of controls，and the inferior cpRNFLT was the thickest，followed by the superior，then the nasal and temporal cpRNFLT，and the difference was statistically significant (P<0.001).Conclusion　Significantly thickening of cpRNFLT and cpTRT has been observed in patients with ODE as compared with controls，so both circumpapillary thickness parameters measured by OCT can be considered as a new non-invasive quantitative index for the detection and research of ODE.

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更新日期/Last Update: 2017-11-01