参考文献/References:
［1］ 方灏,吴昌静,李斯慧,宋晓宇,李小曼.自噬与视网膜疾病［J］.解剖科学进展,2016,(4):429-431.
FANG H,WU CJ,LI SH,SONG XY,LI XM.Autophagy and retinal disease［J］.Prog Anat Sci,2016,(4):429-431.
［2］ 孙文杰,葛红岩,赵楚楚,杨章晖，刘平.自噬在晶状体发育及白内障的研究进展［J］.现代生物医学进展,2015,15(30):5998-6000.
SUN WJ,GE HY,ZHAO CC,YANG ZH,LIU P.Research progress of autophagy in lens development and cataract［J］.Prog Mod Biomed,2015,15 (30):5998-6000.
［3］ MORISHITA H,MIZUSHIMA N.Autophagy in the lens［J］.Exp Eye Res,2016,144(1):22-28.
［4］ COSTELLO MJ,BRENNAN LA,BASU S,CHAUSS D，MOHAMED A,GILLILAND KO,et al.Autophagy and mitophagy participate in ocular lens organelle degradation［J］.Exp Eye Res,2013,116(5):141-150.
［5］ ANDLEY UP,GOLDMAN JW.Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts［J］.Bba-Biomembranes,2016,1860(1):234-239.
［6］ WIGNES JA,GOLDMAN JW,WEIHL CC,BARTLEY MG，ANDLEY UP.P62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract［J］.Exp Eye Res,2013,115(2):263-273.
［7］ SAGONA AP,NEZIS IP,STENMARK H.Association of CHMP4B and autophagy with micronuclei:implications for cataract formation［J］.Biomed Res Int,2014,2014:974393.
［8］ CHEN JH,HUANG C,ZHANG B,YI N,LIANG J,Xu C,et al.Mutations of RagA GTPase in mTORC1 pathway are associated with autosomal dominant cataracts［J］.Plos Genet,2016,12(6):e1006090.
［9］ ZHOU J,YAO K,ZHANG Y,CHENG D,LAI K,YIN H,et al.Thioredoxin binding protein-2 regulates autophagy of human lens epithelial cells under oxidative stress via inhibition of Akt phosphorylation［J］.Oxid Med Cell Longe,2016,2016(13):1-17.
［10］ 闫泉.自噬在干性年龄相关性黄斑变性中的作用研究进展［J］.中华实验眼科杂志,2015,33(10):949-952.
YAN Q.The role of autophagy in the treatment of dry age-related macular degeneration［J］.Chin J Exp Ophthalmol,2015,33 (10):949-952.
［11］ KAI K,SINHA D,BLASIAK J,KAUPPINEN A,VERB Z,SALMINEN A,et al.Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration［J］.Autophagy,2013,9(7):973-984.
［12］ KAARNIRANTA K,KAUPPINEN A,BLASIAK J,SALMINEN A.Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration［J］.Future Med Chem,2012,4(17):2153-2161.
［13］ KLETTNER A,KAUPPINEN A,BLASIAK J,ROIDER J,SALMINEN A,KAARNIRANTA K.Cellular and molecular mechanisms of age-related macular degeneration:From impaired autophagy to neovascularization［J］.Int J Biochem Cell B,2013,45(7):1457-1467.
［14］ SZATMRI-TTH M,KRISTF E,VERB Z,AKHTAR S,FACSK A,FSS L,et al.Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration［J］.Cell Death Dis,2016,7(9):e2367.
［15］ ZHANG J,BAI Y,HUANG L,QI Y,ZHANG Q,LI S,et al.Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E:implications for age-related macular degeneration［J］.Cell Death Dis,2015,6(11):e1972.
［16］ JOHANSSON I,MONSEN VT,PETTERSEN K,MILDENBERGER J,MISUND K,KAARNIRANTA K,et al.The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells［J］.Autophagy,2015,11(9):1636-1651.
［17］ PUA HH,GUO J,KOMATSU M,HEY W.Autophagy is essential for mitochondrial clearance in mature T lymphocytes［J］.J Immunol,2009,182(7):4046-4055.
［18］ SANTEFORD A,WILEY LA,PARK S,BAMBA S,NAKAMURA R,GDOURA A,et al.Impaired autophagy in macrophages promotes inflammatory eye disease［J］.Autophagy,2016,12(10):1876-1885.
［19］ JIA X,LI J,SHI D,ZHAO Y,DONG Y,JU H,et al.Grouping annotations on the subcellular layered interactome demonstrates enhanced autophagy activity in a recurrent experimental autoimmune uveitis T cell line［J］.PLoS One,2015,10(8):e104404.
［20］ ZHENG M,YU H,ZHANG L,LI H,LIU Y,KIJLSTRA A,et al.Association of ATG5 gene polymorphisms with behcet’s disease and ATG10 gene polymorphisms with VKH syndrome in a Chinese han population［J］.Invest Ophthalmol Vis Sci,2015,56(13):8280-8287.
［21］ MOON EK,CHUNG DI,HONG YC,KONG HH.Autophagy protein 8 mediating autophagosome in encysting Acanthamoeba［J］.Mol Biochem Parasit,2009,168(1):43-48.
［22］ WANG Y,HUANG C,ZHANG H,WU R.Autophagy in glaucoma:Crosstalk with apoptosis and its implications.［J］.Brain Res Bull,2015,117(1):1-9.
［23］ PARK HY,KIM JH,PARK CK.Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model［J］.Cell Death Dis,2012,3(4):e290.
［24］ DENG S,WANG M,YAN Z,TIAN Z,CHEN H,YANG X,et al.Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model［J］.PLoS One,2013,8(10):e77100.
［25］ STOTHERT AR,FONTAINE SN,SABBAGH JJ,DICKEY CA.Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma［J］.Exp Eye Res,2015,144(1):38-45.
［26］ BO Q,MA S,HAN Q,WAN FE,LI X,ZHANG Y.Role of autophagy in photoreceptor cell survival and death［J］.Crit Rev Eukar Gene,2015,25(1):23-32.
［27］ ZHOU Z,DOGGETT TA,SENE A,APTER S,FERGUSONT A.Autophagy supports survival and phototransduction protein levels in rod photoreceptors［J］.Cell Death Differ,2015,22(3):488-498.
［28］ ELASRAG ME,SERGOUNIOTIS PI,MCKIBBIN M,PLAGNOL V，SHERIDAN E,WASEE MN,et al.Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement［J］.Am J Hum Genet,2015,96(6):948-954.
［29］ PERUSE KL,SAHU B,PARMAR T,MAENO H,ARAI E,LEY Z,et al.Di-retinoid-pyridinium-ethanolamine (A2E) accumulation and the maintenance of the visual cycle are independent of ATG7-mediated autophagy in the retinal pigmented epithelium［J］.J Biol Chem,2015,290(48):29035-29044.
［30］ SHELBY SJ,ANGADI PS,ZHENG QD,YAO J,JIA L,ZACKSAD N.Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment［J］.Exp Eye Res,2015,137(1):84-93.
［31］ CHINSKEY ND,ZHENG QD,ZACKS DN.Control of photoreceptor autophagy after retinal detachment:The switch from survival to death［J］.Invest Ophthalmol Vis Sci,2014,55(2):688-695.
［32］ DONG K,ZHU ZC,WANG FH,KEG J,YU Z,XU X.Activation of autophagy in photoreceptor necroptosis after experimental retinal detachment［J］.Int J Ophthalmol-Chin,2014,7(5):745-752.
［33］ KUNCHITHAPAUTHAM K,ROHRER B.Autophagy is one of the multiple mechanisms active in photoreceptor degeneration［J］.Autophagy,2007,3(1):65-66.
［34］ RODRGUEZMUELA N,HERNNDEZPINTO AM,SERRANOPUEBLA A,GARCA-LEDO L,LATORRES H,ROSAE J,et al.Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa［J］.Cell Death Differ,2015,22(3):476-487.
［35］ KOCH JC,LINGOR P.The role of autophagy in axonal degeneration of the optic nerve［J］.Exp Eye Res,2016,144(1):81-89.
［36］ 孟永,黄丽琴,郑健樑,张文忻，林健贤,李永平,等.三氧化二砷诱导的视网膜母细胞瘤SO-Rb50细胞自噬的研究［J］.中华实验眼科杂志,2012,30(12):1060-1064.
MENG Y,HUANG LQ,ZHENG JL,ZHANG WX,LIN JX,LI YP,et al.Study on autophagy of SO-Rb50 cells induced by arsenic trioxide［J］.Chin J Exp Ophthalmol,2012,30 (12):1060-1064.
［37］ ZHENG XY,LI LJ,LI W,JIANG PF，SHEN HQ，CHEN YH，et al.Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition［J］.Graefes Arch Clin Exp,2015,253(12):2309-2315.
［38］ LIU K,HUANG J,XIE M,YU Y,ZHU SH,KANG R，et al.MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell［J］.Autophagy,2014,10(3):442-452.
［39］ WANG Y,ABUASAB MS,SHEN D,ZHUANG Z，CHEW EY,CHAN CC.Upregulation of hypoxia-inducible factors and autophagy in von Hippel-Lindau-associated retinal hemangioblastoma［J］.Graefes Arch Clin Exp,2014,252(8):1319-1327.