[1]杜虹,陆慧琴,戴荣平.系统性红斑狼疮眼底病变评估和分型[J].眼科新进展,2017,37(8):766-769.[doi:10.13389/j.cnki.rao.2017.0194]
 DU Hong,LU Hui-Qin,DAI Rong-Ping.Evaluation and types of fundus characters in systemic lupus erythematosus[J].Recent Advances in Ophthalmology,2017,37(8):766-769.[doi:10.13389/j.cnki.rao.2017.0194]
点击复制

系统性红斑狼疮眼底病变评估和分型/HTML
分享到:

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年8期
页码:
766-769
栏目:
应用研究
出版日期:
2017-08-05

文章信息/Info

Title:
Evaluation and types of fundus characters in systemic lupus erythematosus
作者:
杜虹陆慧琴戴荣平
100730 北京市,中国医学科学院北京协和医院眼科(杜虹,戴荣平);710002 陕西省西安市第一医院眼科 (陆慧琴)
Author(s):
DU HongLU Hui-QinDAI Rong-Ping
Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences(DU Hong,DAI Rong-Ping),Beijing 100730,China;Department of Ophthalmology,the First Hospital of Xi’an (LU Hui-Qin),Xi’an 710002,Shaanxi Province,China
关键词:
系统性红斑狼疮眼底荧光血管造影Purtscher样视网膜病变活动性指数
Keywords:
systemic lupus erythematosusfluorescein fundus angiographyPurt-scher like retinopathyactivity index
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2017.0194
文献标志码:
A
摘要:
目的 分析系统性红斑狼疮患者的眼底表现特征。方法 对27例(54眼)眼底有病变的系统性红斑狼疮患者行荧光素眼底血管造影检查并与眼底检查结合进行综合分析。对患者的系统性红斑狼疮活动性指数(systemic lupus erythematosus disease activity index,SLEDAI)进行计算,并采用SPSS 19.0中的t检验进行统计分析。结果 27例患者的眼底表现可以分为4种类型,即毛细血管阻塞型(14例28眼)、动脉阻塞型(6例11眼)、静脉阻塞型(6例7眼)和脉络膜血管阻塞型(1例2眼)。24例患者进行了SLEDAI评分。5例动脉阻塞型患者的SLEDAI为(25.6±2.2)分,显著高于其他患者的SLEDAI评分(18.2±2.9)分(P<0.05)。结论 不同血管阻塞的分型有助于了解系统性红斑狼疮患者的眼底病变情况,并可能与疾病活动程度相关。动脉阻塞型的SLEDAI评分高于其他类型。
Abstract:
Objective To analyze the clinical characteristics of fundus changes in systemic lupus erythematosus (SLE) patients.Methods Color fundus and FFA were performed in 27 SLE patients (54 eyes) with fundus abnormalities.Clinical characteristics were analyzed.SLE disease activity index (SLEDAI) was evaluated in the patients.SLEDAI was analyzed by SPSS 19.0 Student-t test.Results Four clinical types were found in 27 patients.Capillary obstruction was found in 28 eyes of 14 patients,retinal artery occlusion in 11 eyes of 6 patients,retinal vein occlusion in 7 eyes of 6 patients,choroidal vessel obstruction in 2 eyes of 1 patient.SLEDAI was evaluated in 24 patients.SLEDAI in 5 patients with retinal artery occlusion was (25.6±2.2) scores,which was significantly higher than other patients(18.2±2.9)scores (P<0.05).Conclusion This clinical typing scheme may help to know fundus abnormalities in SLE patient,and it may be related to SLE activity.SLEDAI in patients with retinal artery occlusion is higher than other patients.

参考文献/References:

[1] 唐雪梅.系统性红斑狼疮遗传学研究进展 [J].中华实用儿科临床杂志,2016,31(21):1601-1604.
TANG XM.Advances in the genetics of systemic lupus erythematosus[J].Chin J Appl Clin Pediatr,2016,31(21):1601-1604.
[2] LEE JH,KIM SS,KIM GT.Microvascular findings in patients with systemic lupus erythematosus assessed by fundus photography with fluorescein angiography[J].Clin Exp Rheumatol,2013,31(6):871-876.
[3] 陈乔,聂尚武,王晓琴,陈盼.合并视网膜大血管阻塞的系统性红斑狼疮的临床观察[J].国际眼科杂志,2015,15(12):2167-2170.
CHEN Q,NIE SW,WANG XQ,CHEN P.Clinic observation of systemic lupus erythematosus complicated with major retinal vascular occlusion[J].Int Eye Sci,2015,15(12):2167-2170.
[4] AU A,O’DAY J.Renew of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphospholipid syndrome:associations,visual outcomes,complications and treatment[J].Clin Exper Ophthalmol,2004,32(1):87-100.
[5] 戴荣平,董方田,郑霖,王造文,于伟泓,许卓在,等.Purtscher样视网膜病变[J].中华眼科杂志,2007,43(5):447-450.
DAI RP,DONG FT,ZHENG L,WANG ZW,YU WH,XU ZZ,et al.The clinical features of Purtscher-like retinopathy[J].Chin J Ophthalmol,2007,43(5):447-450.
[6] GRIFFITHS B,MOSCA M,GORDON C.Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices[J].Best Pract Res Clin Rheumatol,2005,19(5),685-708.
[7] BARKENH HJ,MUHAYA M.Optic neuritis and retinal vasculitis as primary manifestation of systemic lupus erythematosus[J].Med J Malaysia,2002,57(4):490-492.
[8] SILPA-ARCHA S,LEE JJ,FOSTER CS.Ocular manifestations in systemic lupus erythematosus[J].Br J Ophthalmol,2016,100(1):135-141.
[9] WU C,DAI R,DONG F,WANG Q.Purtscher-like retinopathy in systemic lupus erythematosus[J].Am J Ophthalmol,2014,158(6):1335-1341.
[10] 夏晓茹,徐宏,秦苇,刘银和,朱小春.系统性红斑狼疮的视网膜血管病变程度与疾病活动的相关性[J].温州医科大学学报,2014,44(4):268-271.
XIA XR,XU H,QIN W,LIU YH,ZHU XC.Correlative study on retinal vascular lesions on systemic lupus erythematosus and disease activity[J].J Wenzhou Med Univ,2014,44(4):268-271.
[11] 周慧颖,叶俊杰,王淑然.系统性红斑狼疮眼底病变的特征[J].中华眼视光学与视觉科学杂志,2015,17(5):270-274.
ZHOU HY,YE JJ,WANG SR.Observation of the ocular fundus manifestations of systemic lupus erythematosus[J].Chin J Optom Ophthalmol Vis Sci,2015,17(5):270-274.
[12] TOLBA DA,EL-FAYOUMI DM,ABDELAZIZ MS,NABIH MH.Fluorescein angiographic findings in patients with active systemic lupus erythematosus[J].Ocul Immunol Inflamm,2016,20(1):1-7.
[13] EDOUARD S,DOUAT J,SAILLER L,ARLET P,ASTUDILLO L P.Bilateral choroidopathy in systemic lupus erythematosus[J].Lupus,2011,20(11):1209-1210.
[14] 辛梅,张美霞,张军军.全身应用皮质类固醇激素致中心性浆液性脉络膜视网膜病变的临床特征[J].中华眼视光学与视觉科学杂志,2013,15(1):10-13.
XIN M,ZHANG MX,ZHANG JJ.Clinical features of central serous chorioretinopathy caused by systemic application of corticosteroids[J].Chin J Optom Ophthalmol Vis Sci,2013,15(1):10-13.
[15] DE ANDRADE FA,GUIMARES-MOREIRA BG,BORTOLOTI-AZEVEDO LG,PROVENZANOS G,VIEIRA-MORAES JH,MENDES-KLUMB E,et al.Neuro-ophthalmologic manifestations in systemic lupus erythematosus[J].Lupus,2017,26(5):522-528.

相似文献/References:

[1]李娟娟 李燕.慢性中心性浆液性脉络膜视网膜病变视网膜色素上皮细胞萎缩轨迹的临床观察[J].眼科新进展,2013,33(8):000.
[2]刘卫华 杨新怀 黄勤 聂鑫 覃旭方 全婵娟.OCT与FFA在中心性浆液性脉络膜视网膜病变检查中的应用比较[J].眼科新进展,2013,33(9):000.
[3]陆莹 赵菊莲.进口与国产荧光素钠在眼底血管造影中不良反应的对比研究[J].眼科新进展,2012,32(3):000.
[4]李娟娟 李燕.先天性及获得性视盘血管袢的临床观察[J].眼科新进展,2013,33(11):000.
[5]冀向宁,刘玉青,韩风梅,等. OCT与FFA在糖尿病视网膜病变临床前期的应用比较[J].眼科新进展,2014,34(7):662.[doi:10.13389/j.cnki.rao.2014.0181]
[6]李士清,李晓华,李萍,等.近红外自发荧光联合荧光血管造影在黄斑脉络膜裂伤合并视神经钝挫伤中的应用[J].眼科新进展,2014,34(10):934.[doi:10.13389/j.cnki.rao.2014.0258]
[7]万敏婕,杨先凤.SD-OCT及FFA在白内障术后黄斑囊样水肿研究中的应用[J].眼科新进展,2015,35(1):055.[doi:10.13389/j.cnki.rao.2015.0016]
 WAN Min-Jie,YANG Xian-Feng.Evaluation of cystoid macular edema using optical coherence tomography and fundus fluorescein angiography after cataract surgery[J].Recent Advances in Ophthalmology,2015,35(8):055.[doi:10.13389/j.cnki.rao.2015.0016]
[8]罗洁,杨海军,李小平. 频域OCT与FFA在糖尿病视网膜病变患者中的应用[J].眼科新进展,2015,35(5):463.[doi:10.13389/j.cnki.rao.2015.0126]
 LUO Jie,YANG Hai-Jun,LI Xiao-Ping. Application comparative study on frequency domain OCT and FFA in patients with diabetic retinopathy[J].Recent Advances in Ophthalmology,2015,35(8):463.[doi:10.13389/j.cnki.rao.2015.0126]
[9]庄海容,刘平,胡学政. 高度近视患者黄斑区脉络膜新生血管的特征分析[J].眼科新进展,2015,35(8):743.[doi:10.13389/j.cnki.rao.2015.0203]
 ZHUANG Hai-Rong,LIU Ping,HU Xue-Zheng. Characteristics analysis of high myopia patients with macular choroidal neovascularization[J].Recent Advances in Ophthalmology,2015,35(8):743.[doi:10.13389/j.cnki.rao.2015.0203]
[10]王敏,王怀华,徐楠楠,等. 局灶性脉络膜凹陷的临床特征分析[J].眼科新进展,2015,35(9):866.[doi:10.13389/j.cnki.rao.2015.0236]
 WANG Min,WANG Huai-Hua,XU Nan-Nan,et al. Clinical characteristics of focal choroidal excavation[J].Recent Advances in Ophthalmology,2015,35(8):866.[doi:10.13389/j.cnki.rao.2015.0236]

更新日期/Last Update: 2017-08-14