[1]吴凤鸣,李亚军,肖满意,等.屈光不正性弱视儿童白质结构变化的扩散张量成像（DTI）分析[J].眼科新进展,2017,37(6):551-554.[doi:10.13389/j.cnki.rao.2017.0139]
　WU Feng-Ming,LI Ya-Jun,XIAO Man-Yi,et al.DTI analysis on white matter changes in children with ametropic amblyopia[J].Recent Advances in Ophthalmology,2017,37(6):551-554.[doi:10.13389/j.cnki.rao.2017.0139]
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屈光不正性弱视儿童白质结构变化的扩散张量成像（DTI）分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年6期
页码:
551-554
栏目:
应用研究
出版日期:
2017-06-05

文章信息/Info

Title:
DTI analysis on white matter changes in children with ametropic amblyopia
作者:
吴凤鸣; 李亚军; 肖满意; 魏欣; 郝铸; 刘锦
410000　湖南省长沙市，中南大学湘雅二医院
Author(s):
WU Feng-Ming; LI Ya-Jun; XIAO Man-Yi; WEI Xin; HAO Zhu; LIU Jin
Second Xiangya Hospital，Central South University，Changsha 410000，Hunan Province，China
关键词:
弱视; 屈光不正; 扩散张量成像; 确定性追踪; 部分各向异性值; 纤维束数目值
Keywords:
amblyopia; ametropia; diffusion tensor imaging; deterministic tractography; fractional anisotropy; tract count
分类号:
R777.4
DOI:
10.13389/j.cnki.rao.2017.0139
文献标志码:
A
摘要:
目的　应用扩散张量成像（diffusion tensor imaging，DTI）技术和确定性追踪全脑分析法评估双眼屈光不正弱视儿童脑白质神经纤维结构的异常，并分析其与视力的相关性。方法　收集中南大学湘雅二医院眼科14例临床确诊双眼屈光不正性弱视患儿为试验组，14例正常儿童为对照组。所有儿童均采用磁共振成像系统进行扫描，行常规MRI检查、3DT1WI扫描，及平面回波序列（EPI）扫描得到扩散加权成像。运用确定性追踪法对所有DTI图像进行定量分析，将研究组部分各向异性（fractional anisotropy，FA）值、纤维束体积及纤维束数目显著改变的纤维束作为感兴趣区，与视力之间作相关性分析。结果　试验组相比对照组在右侧腹侧通路和背侧通路、右侧视辐射及胼胝体FA值下降，双侧腹侧通路和背侧通路、左侧视辐射、胼胝体体部纤维束体积相比对照组下降，右侧背侧通路纤维束数目相比对照组减少。FA值、纤维束数目和纤维束体积之间，FA值与视力的回归系数最大，纤维束数目和纤维束体积回归系数小，右侧视辐射、右侧腹侧通路及胼胝体体部的FA值与视力的相关系数分别为0.486、0.534和0.456，右侧腹侧通路FA值与视力的相关系数最大。结论　屈光不正性弱视患者双侧视辐射、双侧腹侧背侧通路及胼胝体体部白质纤维束结构均有异常，可导致屈光不正弱视患者物体识别、空间位置及运动识别能力减退。右侧腹侧通路FA值对视力的影响最大。
Abstract:
Objective　To evaluate white matter nerve fiber changes of children with binocular ametropic amblyopia by applying the technology of diffusion tensor imaging and the whole brain analysis method of deterministic tractography，and analyze its correlation with visual acuity.Methods　Fourteen binocular ametropic amblyopia children was collected from the Second Xiangya Hospital of Central South University as study subject of experimental group，14 cases of normal sight children as the control group.All children were scanned by MRI system，conventional MRI examination，3DT1WI scan were made，then echo-planar sequence scanning was used to obtain diffusion tensor imaging.Quantitative analysis was made to all diffusion tensor imaging using deterministic tractography.Using the experimental group tracts with statistic changes of FA value，volume and tract count as the region of interest(ROI)，the correlation analysis with vision for each ROI was performed.Results　Isoametropic amblyopia children demonstrated low FA values in the right ventral and dorsal pathway，right optic radiation and corpus callosum compared to control group.There was low volume of fibers in the bilateral ventral and dorsal pathway，the left optic radiation and body of corpus callosum compared to control group.The tract count of right dorsal pathway had reduced compared to control group.Among FA value，tract count and volume，FA value had the maximum regression coefficient with visual acuity，the regression coefficient of tract count and volume was small.The relative correlation coefficient of FA value at right optic radiation，right ventral pathway and body of corpus callosum with vision acuity were 0.486，0.534 and 0.456，respectively，the right ventral pathway had the maximum correlation with visual acuity.Conclusion　Isoametropic amblyopia patients shows abnormal structure on bilateral optic radiation，bilateral ventral and dorsal pathway and body of corpus callosum，these may cause the capability loss of object recognition and spatial position recognition.The FA value of right ventral pathway has the maximum influence on visual acuity.

参考文献/References:

［1］　甘晓玲.弱视的定义、分类及疗效评价标准［J］.中国斜视与小儿眼科杂志，1996，4（3）：3.
GAN XL.The definition，classification and evaluation criteria of amblyopia［J］.Chin J Strabismus Pediatr Ophthalmol，1996，4（3）：3.
［2］　CHOI MY，LEE KM，HWANG JM，CHOI DG，LEE DS，PARK KH.Comparison between anisometropic and strabismic amblyopia using functional magnetic resonance imaging［J］.Br J Ophthalmol，2001，85（9）：1052-1056.
［3］　BARRETT BT，BRADLEY A，CANDY TR.The relationship between anisometropia and amblyopia［J］.Prog Retin Eye Res，2013，36（2）：120-158.
［4］　JONES DK，KNOSCHE TR，TURNER R.White matter integrity，fiber count，and other fallacies：the do’s and don’ts of diffusion MRI［J］.Neuroimage，2013，73（3）：239-254.
［5］　BARNES GR，LI X，THOMPSON B，SINGH KD，DUMOULIN SO，HESS RF.Decreased gray matter concentration in the lateral geniculate nuclei in human amblyopes［J］.Invest Ophthalmol Vis Sci，2010，51（3）：1432-1438.
［6］　HESS RF，THOMPSON B，GOLE GA，MULLEN KT.The amblyopic deficit and its relationship to geniculo-cortical processing streams［J］.J Neurophysiol，2010，104（1）：475-483.
［7］　QI S，MU YF，CUI LB，LI R，SHI M，LIU Y.Association of optic radiation integrity with cortical thickness in children with anisometropic amblyopia［J］.Neurosci Bull，2016，32（1）：51-60.
［8］　CHAN KC，CHENG JS，FAN S，ZHOU IY，YANG J，WU EX.In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced MRI and diffusion tensor imaging［J］.Neuroimage，2012，59（3）：2274-2283.
［9］　LI Q，JIANG Q，GUO M，LI Q，CAI C，YIN X.Grey and white matter changes in children with monocular amblyopia：voxel-based morphometry and diffusion tensor imaging study［J］.Br J Ophthalmol，2013，97（4）：524-529.
［10］　KIKINIS Z，MAKRIS N，FINN CT，BOUIX S，LUCIA D，COLEMAN MJ.Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome［J］.Brain Imaging Behav，2013，7（3）：316-325.
［11］　ORTIBUS E，VERHOEVEN J，SUNAERT S，CASTEELS I，COCK PD，LAGAE L.Integrity of the inferior longitudinal fasciculus and impaired object recognition in children：a diffusion tensor imaging study［J］.Dev Med Child Neurol，2012，54（1）：38-43.
［12］　LI Q，ZHAI L，JIANG Q，QIN W，LI Q，YIN X.Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia［J］.Neurosci Lett，2015，597（1）：7-12.
［13］　杨益刚，郭娴吟，王忠.弥散张量成像检测单眼成人弱视患者视放射及胼胝体白质发育情况［J］.实用临床医学，2015，16（7）：69-72.
YANG YG，GUO XY，WANG Z.Diffusion tensor imaging in the detection of optic radiation and corpus callosum white matter development in monocular amblyopia［J］.Pract Clin Med，2015，16（7）：69-72.
［14］　FARZIN F，NORCIA AM.Impaired visual decision-making in individuals with amblyopia［J］.J Vis，2011，11（14）：6.
［15］　刁丽梅，陈子蓉，黄东红.左侧颞叶癫痫患者执行功能损害与钩束弥散张量成像参数的相关性［J］.中国神经精神疾病杂志，2013，39（8）：474-478.
DIAO LM，CHEN ZR，HUANG DH.Correlation between executive function impairment and the parameters of the uncinate bundle diffusion tensor imaging in patients with left temporal lobe epilepsy［J］.Chin J Nervous Mental Diseases，2013，39（8）：474-478.

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备注/Memo

备注/Memo:
湖南省自然科学基金资助（编号：13jj5013）
更新日期/Last Update: 2017-06-28