[1]何珂,张鹏,李晓清,等.炎性肠病患者病情与脉络膜厚度的关系[J].眼科新进展,2017,37(5):469-472.[doi:10.13389/j.cnki.rao.2017.0119]
　HE Ke,ZHANG Peng,LI Xiao-Qing,et al.Relationship between disease activity and choroidal thickness in patients with inflammatory bowel disease[J].Recent Advances in Ophthalmology,2017,37(5):469-472.[doi:10.13389/j.cnki.rao.2017.0119]
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炎性肠病患者病情与脉络膜厚度的关系/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年5期
页码:
469-472
栏目:
应用研究
出版日期:
2017-05-05

文章信息/Info

Title:
Relationship between disease activity and choroidal thickness in patients with inflammatory bowel disease
作者:
何珂; 张鹏; 李晓清; 杨琦; 丁小艳; 郭省香; 李淼; 王建洲
710018　陕西省西安市，西安市第三医院眼科（何珂，张鹏，李晓清，丁小艳，郭省香，李淼，王建洲）；710018　陕西省西安市，西安市第三医院消化内科（杨琦）
Author(s):
HE Ke; ZHANG Peng; LI Xiao-Qing; YANG Qi; DING Xiao-Yan; GUO Sheng-Xiang; LI Miao; WANG Jian-Zhou
Department of Ophthalmology，the Third Hospital of Xi’an（HE Ke，ZHANG Peng，LI Xiao-Qing，DING Xiao-Yan，GUO Sheng-Xiang，LI Miao，WANG Jian-Zhou），Xi’an 710018，Shaanxi Province，China；Department of Gastroenterology，the Third Hospital of Xi’an（YANG Qi），Xi’an 710018，Shaanxi Province，China
关键词:
炎性肠病; 溃疡性结肠炎; 克隆恩病; 脉络膜; 葡萄膜炎; 光学相干断层扫描
Keywords:
inflammatory bowel disease; ulcerative colitis; crohn’s disease; choroid; uveitis; optical coherence tomography
分类号:
R773.4
DOI:
10.13389/j.cnki.rao.2017.0119
文献标志码:
A
摘要:
目的　通过分析不同病情的炎性肠病（inflammatory bowel disease，IBD）与脉络膜厚度的关系，探讨将脉络膜厚度用于评价IBD病情的可行性。方法　光学相干断层扫描仪的增强深部扫描技术对50例（100眼）不同病情的IBD患者的脉络膜厚度进行测量，包括23例溃疡性结肠炎（ulcerative colitis，UC）和27例克罗恩病（Crohn’s disease，CD）患者，另有48名（96眼）健康志愿者作为对照被纳入研究。结果　与正常志愿者的黄斑中心凹下脉络膜厚度（294.37±35.04）μm相比较，UC患者中病情为重度者的黄斑中心凹下脉络膜厚度（349.28±76.57）μm增加显著（P＜0.05），CD患者中病情为中度者及重度者的黄斑中心凹下脉络膜厚度［（326.71±59.71）μm、（354.24±66.34）μm］也均增加显著（均为P＜0.05）。结论　脉络膜厚度可作为评价IBD患者尤其是CD患者病情严重程度的指标。
Abstract:
Objective　To investigate the relationship between inflammatory bowel disease （IBD） activity and choroidal thickness，and evaluate the utility of a choroidal thickness measurement in assessing IBD activity.Methods　A total of 100 eyes of 50 patients of IBD with different disease activity，including 23 patients of ulcerative colitis，27 patients of Crohn’s disease （CD）.Ninety-six eyes of 48 healthy volunteers were recruited as control group.Choroidal thickness was measured using enhanced depth imaging（EDI）optical coherence tomography.Results　Compared with the subfoveal choroidal thickness （294.37±35.04）μm in healthy volunteers，the subfoveal choroidal thickness （349.28±76.57）μm in UC patients with severe disease activity，the subfoveal choroidal thickness （326.71±59.71）μm and （354.24±66.34）μm，respectively,in CD patients with moderate and severe disease activity were found to be increased significantly （all P<0.05）.Conclusion　Choroidal thickness should be considered as a potential marker to assess the disease activity in patients with IBD，especially in patients with CD.

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更新日期/Last Update: 2017-06-07