[1]许卓珺,余克明,庄菁.诱导多能干细胞向神经视网膜细胞定向分化的研究进展[J].眼科新进展,2016,36(9):885-888.[doi:10.13389/j.cnki.rao.2016.0238]
　XU Zhuo-Jun,YU Ke-Ming,ZHUANG Jing.Research progress on differentiation from induced pluripotent stem cells into neural retinal cells[J].Recent Advances in Ophthalmology,2016,36(9):885-888.[doi:10.13389/j.cnki.rao.2016.0238]
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诱导多能干细胞向神经视网膜细胞定向分化的研究进展
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年9期
页码:
885-888
栏目:
文献综述
出版日期:
2016-09-05

文章信息/Info

Title:
Research progress on differentiation from induced pluripotent stem cells into neural retinal cells
作者:
许卓珺; 余克明; 庄菁
510060　广东省广州市，中山大学中山眼科中心，眼科学国家重点实验室
Author(s):
XU Zhuo-Jun; YU Ke-Ming; ZHUANG Jing
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center , Sun Yat-sen University , Guangzhou 510060 , Guangdong Province , China
关键词:
诱导多能干细胞; 定向分化; 神经视网膜细胞; 视网膜退行性病变
Keywords:
induced pluripotent stem cells ;  differentiation ;  neural retinal cell;  retinal degeneration disease
分类号:
Ｒ７７４.６
DOI:
10.13389/j.cnki.rao.2016.0238
文献标志码:
A
摘要:
视网膜退行性病变是造成视觉损害乃至失明的重要原因，由于成年视网膜组织无法自我更新病变中丢失的细胞，导致视网膜退行性病变具有不可逆性。诱导多能干细胞具有自我更新和多向分化的巨大潜力，是建立疾病模型、研究细胞替代疗法的理想供体。本文重点论述诱导多能干细胞的获取及其向神经视网膜细胞定向分化方面的研究进展，为视网膜退行性病变的实验室研究和临床诊治提供一定参考。
Abstract:
Retinal degeneration diseases are the leading cause of visual impairment and blindness.this kind of blindness is always irreversible because the loss of retinal cells in these diseases can not be renewed. Induced pluripotent stem cell has an unlimited capacity for self-renewal and is able to differentiate into multiple cell types, which makes it a great candidate to build disease model and develop cell replacement therapy. This article reviews the research progress on the generation of induced pluripotent stem cell and the differentiation from induced pluripotent stem cells into neural retinal cells . in order to provide a reference for the laboratory study and clinical treatment of retinal degeneration diseases.

相似文献/References:

[1]王松涛,周国民.诱导多能干细胞在视网膜疾病研究中的应用[J].眼科新进展,2017,37(6):587.[doi:10.13389/j.cnki.rao.2017.0149]
　WANG Song-Tao,ZHOU Guo-Min.Application of induced pluripotent stem cells in retinal diseases[J].Recent Advances in Ophthalmology,2017,37(9):587.[doi:10.13389/j.cnki.rao.2017.0149]

更新日期/Last Update: 2016-09-09