角膜基质及结膜下单次注射康柏西普治疗角膜新生血管的疗效及安全性-《眼科新进展》

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Title:: Efficacy and safety of one dose intrastromal and subconjunctival conbercept injection for corneal neovascularization

Author(s):: WANG Wei ; XU Lin-Juan ; CAI Su-Bo ; ZHANG Xian; GUO Jing-Min ; LI Xin-Yu ; ZHANG Hong ; LI Gui-Gang; Department of Ophthalmology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 . Hubei Province , China

Keywords:: corneal intrastromal inj ection ; subconjunctival injection ; conbercept ; corneal neovascularization

摘要:: 目的　观察角膜基质及结膜下单次注射康柏西普治疗角膜新生血管的疗效及安全性。方法　采用前瞻性自身对照研究方法，对８例角膜新生血管患者行角膜基质及结膜下各注射康柏西普约２０μＬ（０．２ｍｇ）。通过观察角膜新生血管的形态及面积变化评价其治疗效果，通过视力及眼压变化评价其安全性。结果　８例患者术前第１天、术后第７天及术后３个月的角膜新生血管面积分别为（１７．８３±５．６４）ｍｍ２、（１２．５８±４．５２）ｍｍ２和（１４．６４±４．１８）ｍｍ２，患者术后第７天和３个月的角膜新生血管面积与术前第１天相比，差异均有统计学意义（均为Ｐ＜０．０５）。术后第７天视力和术前第１天相比，差异无统计学意义（Ｐ＞０．０５）。术后第１天和第７天眼压与术前第１天相比，差异均无统计学意义（均为Ｐ＞０．０５）。结论　角膜基质及结膜下单次注射康柏西普可减少角膜新生血管面积，而短期内对视力及眼压无显著影响。

Abstract:: Objective To evaluate the efficacy and safety of one dose intrastromal and subconjunctival conbercept injection for corneal neovascularization ( CNV) . Methods Eight patients (8 eyes) with CNV were collected.and the intrastromal and subconjunctival conbercept injection about 20 VL ( 0. 2 mg) were given. The morphology and area were observed to evaluate the efficacy of conbercept for CNV. Visual acuity and intraocular pressure were observed to evaluate its safety. Results The preoperative area of CNV was ( 17. 83 +5. 64) mm2. At postoperative 7 days and 3 months , the area were ( 12. 58 +4. 52 ) mm2 and ( 14. 64 +4. 18 ) mm2 , respectively , there were statistical differences compared with pre-operation ( all P < 0. 05 ) . There was no statistical difference rn visual acuity between preoperative I day and postoperative 7 days (P > 0. 05 ) . There was no statistical difference in intraocular pressure at postoperative I day ,7 days compared with preoperative I day ( all P > 0. 05 ) . Conclusion One dose intrastromal and subconjunctival conbercept injection can reduce CNV. and has no significant effect on visual acuity and intraocular pressure in short-term.