[1]杜娟,姜楠,邵毅,等.纤维蛋白胶治疗角膜板栗刺伤的临床研究[J].眼科新进展,2016,36(4):336-339.[doi:10.13389/j.cnki.rao.2016.0091]
　DU Juan,JIANG Nan,SHAO Yi,et al.Application of fibrin glue on corneal chestnut thorns injury[J].Recent Advances in Ophthalmology,2016,36(4):336-339.[doi:10.13389/j.cnki.rao.2016.0091]
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纤维蛋白胶治疗角膜板栗刺伤的临床研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年4期
页码:
336-339
栏目:
应用研究
出版日期:
2016-04-05

文章信息/Info

Title:
Application of fibrin glue on corneal chestnut thorns injury
作者:
杜娟; 姜楠; 邵毅; 李志辉; 赵奋图
528300　广东省佛山市，南方医科大学附属顺德第一人民医院眼科（杜娟，李志辉，赵奋图）；330006　江西省南昌市，南昌大学第一附属医院眼科（姜楠，邵毅）
Author(s):
DU Juan ; JIANG Nan ; SHAO Yi;  LI Zhi-Hui; ZHAO Fen-Tu
Department of Ophthalmology , the First People ’ s Hospital of Shunde , Southern Medical University ( DU Juan , LI Zhi-Hui , ZHAO Fen-Tu ) , Foshan 528300 , Guangdong Province , China ; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University ( JIANG Nan, SHAO Yi ) , Nanchang 330006 , Jiangxi Province , China
关键词:
纤维蛋白胶; 角膜异物; 板栗刺伤; 超声生物显微镜
Keywords:
fibrin glue;  corneal foreign body;  chestnut thorns injury;  UBM
DOI:
10.13389/j.cnki.rao.2016.0091
文献标志码:
A
摘要:
目的　观察纤维蛋白胶治疗角膜板栗刺伤的临床效果。方法　采用前瞻性随机对照研究方法，选取年龄、病程等重要非试验因素，按不平衡指数最小的分配原则将２０１０年１月至２０１５年１月在顺德市第一人民医院和南昌大学第一附属医院确诊板栗刺导致的角膜深层异物患者６０例（６０眼）随机分为机械剔除组和纤维蛋白胶组（各３０例３０眼）。机械剔除组行裂隙灯下异物摘除术，纤维蛋白胶组于角膜表面注入纤维蛋白黏合胶。术后随访１个月，观察眼表指数、基础泪液分泌量、测量泪河高度和泪液蛋白含量变化，使用超声生物显微镜观察眼表愈合情况。结果　机械剔除组患者异物取出时间（１２±４）ｍｉｎ，显著高于纤维蛋白胶组的（３±２）ｍｉｎ，差异有统计学意义（ｔ＝９．４２６，Ｐ＜０．０５）。机械剔除组患者角膜上皮愈合时间为（１４±２）ｄ，长于纤维蛋白胶组的（５±１）ｄ，差异有统计学意义（ｔ＝１８．２６３，Ｐ＜０．０５）。术后１周两组患者眼表指数、泪河高度及基础泪液分泌量相比，差异均有统计学意思（均为Ｐ＜０．０５）；术后１周超声生物显微镜检查发现，机械剔除组角膜上皮仍未愈合，角膜基质水肿明显，刺伤区角膜反光明显，而纤维蛋白胶组角膜上皮已完全愈合，角膜基质水肿消退，刺伤区角膜反光接近正常角膜区域。结论　纤维蛋白胶治疗角膜板栗刺伤能减少手术时间，减轻角膜水肿，有益于角膜愈合，是一种安全有效的方法。
Abstract:
Objective To observe the clinical effects of treating corneal chestnut thorns injury by fibrin glue. Methods A prospective and randomized study. The important non experimental factors , such as age , course of disease were considered to select the subjects. According to the unbalanced index minimum principle of distribution . the 60 patients diagnosed as corneal chestnut thoms injury during January 2010 to January 2015 in the First People ’ s Hospital of Shunde City and the First Affiliated Hospital of Nanchang University were randomly divided into mechanical eliminate group and fibrin glue group,each group including 30 cases (30 eyes). The mechanical eliminate group removed the foreign bodies under the slit lamp , and the fibrin glue group injected the fibrin glue adhesive on corneal surface. The follow-up time was I month ,the ocular surface disease index . Schirmer I test ( SIT) , tear meniscus height,tear protein were detected, and UBM was used to observe the ocular surface healing. Results The surgical average time in the mechanical eliminate group was ( 12 +4) nunutes ,while in the fibrin glue group was (3 +2) minutes.there was statistically significance ( t = 9. 426 , P < 0. 05 ) . The healing time of comeal injuries in the mechanical elinunate group was ( 14 + 2 ) days, while in the fibrin glue group was ( 5 + I ) days , there was statistically significance ( t = 18. 263 .P < 0. 05 ) . One week after operation, the differences in the ocular surface disease index , tear river height and SIT between the two groups were sigruficant ( all P < 0. 05 ) . One week after operation. UBM showed that the corneal epithelial of mechanical eliminate group did not heal.corneal stroma was obvious edema. the damage area reflected obviously , but the corneal epithelial of fibrin glue group healed completely , corneal stroma edema disappeared,reflection of the damage area was sinular to normal corneal area. Conclusion The corneal chestnut thorns injury treated by fibrin glue can reduce the operation time and decrease the corneal edema.which is a safe and effective method.

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[1]王秀,杨军,宁玉贤,等.纤维蛋白胶在翼状胬肉手术中应用的研究进展[J].眼科新进展,2016,36(2):186.[doi:10.13389/j.cnki.rao.2016.0051]
　WANG Xiu,YANG Jun,NING Yu-Xian,et al.Recent advances in fibrin glue applied in pterygium surgery[J].Recent Advances in Ophthalmology,2016,36(4):186.[doi:10.13389/j.cnki.rao.2016.0051]
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备注/Memo

备注/Memo:
国家自然科学基金资助（编号： ８１１６０１１８、８１４００３７２）；全国临床医药研究专项基金（编号：Ｌ２０１２０５２）；江西省远航工程（编号：２０１４０２２）；江西省学位与研究生教育教学改革研究项目（编号：２０１５）；江西省科技平台建设项目（编号：２０１３１１６）；江西省青年科学基金（编号：２０１５１ＢＡＢ２１５０１６）；江西省科技支撑计划项目（编号：２０１５１ＢＢＧ７０２２３）；江西省教育厅科技计划项目（编号：ＧＪＪ１４１７０）；江西省卫计委科技计划项目（编号：２０１５５１５４）；赣江学者计划（编号：２０１５）
更新日期/Last Update: 2016-04-01