[1]黄漓莉,于健,周素娴,等.同型半胱氨酸和视黄醇结合蛋白4与糖尿病视网膜病变的相关性研究[J].眼科新进展,2016,36(3):244-246.[doi:10.13389/j.cnki.rao.2016.0065]
　HUANG Li-Li,YU Jian,ZHOU Su-Xian,et al.Correlation analysis of Hcy and RBP4 with diabetic retinopathy[J].Recent Advances in Ophthalmology,2016,36(3):244-246.[doi:10.13389/j.cnki.rao.2016.0065]
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同型半胱氨酸和视黄醇结合蛋白4与糖尿病视网膜病变的相关性研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年3期
页码:
244-246
栏目:
应用研究
出版日期:
2016-03-05

文章信息/Info

Title:
Correlation analysis of Hcy and RBP4 with diabetic retinopathy
作者:
黄漓莉; 于健; 周素娴; 王莉; 彭鹰; 刘晓玲; 荀靖琼
541001　广西壮族自治区桂林市，桂林医学院附属医院内分泌科
Author(s):
HUANG Li-Li ; YU Jian; ZHOU Su-Xian ; WANG Li ;  PENG Ying ;  LIU Xiao-Ling ; XUN Jing-Qiong
Department of Endocrinology , Affiliated Hospital of Guilin Medical College , Guilin 541001 , Guangxi Chuang Autonomous Region , China
关键词:
糖尿病视网膜病变; 同型半胱氨酸; 视黄醇结合蛋白4
Keywords:
diabetic retinopathy ;  homocysteine ; retinol binding protein 4
DOI:
10.13389/j.cnki.rao.2016.0065
文献标志码:
A
摘要:
目的　检测并分析同型半胱氨酸（ｈｏｍｏｃｙｓｔｅｉｎｅ，Ｈｃｙ）及视黄醇结合蛋白４（ｒｅｔｉ-ｎｏｌｂｉｎｄｉｎｇｐｒｏｔｅｉｎ４，ＲＢＰ４）与糖尿病视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）的关系，以探讨对特定人群ＤＲ的诊断方法。方法　选取２０１４年６月到２０１５年６月桂林医学院附属医院内分泌科就诊的２型糖尿病患者２００例，所有患者进行眼底检查必要时行眼底荧光血管造影（ｆｕｎｄｕｓｆｌｕｏｒｅｓｃｅｉｎａｎｇｉｏｇｒａｐｈｙ，ＦＦＡ），根据眼底情况分为增殖期糖尿病视网膜病变（ｐｒｏｌｉｆｅｒａｔｉｖｅｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＰＤＲ）组、非增殖期糖尿病视网膜病变（ｎｏｎ-ｐｒｏｌｉｆｅｒａｔｉｖｅｄｉ-ａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＮＰＤＲ）组，以及非糖尿病视网膜病变（ｎｏｎ-ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＮＤＲ）组；检测各组空腹血糖（ｆａｓｔｉｎｇｐｏｓｔｐｒａｎｄｉａｌｇｌｕｃｏｓｅ，ＦＰＧ）、餐后２ｈ血糖（２-ｈｏｕｒｐｏｓｔｐｒａｎｄｉａｌｇｌｕｃｏｓｅ，２ｈＰＧ）、糖化血红蛋白（ｇｌｙｃｏｓｙｌａｔｅｄｈｅｍｏｇｌｏｂｉｎ，ＨｂＡ１ｃ）、血脂、Ｈｃｙ、ＲＢＰ４水平。结果　ＰＤＲ组的Ｈｃｙ（１７．６０±４．４７）μｍｏｌ·Ｌ－１、ＲＢＰ４（１６．３２±３．５７）μｇ·ｍＬ－１及ＮＰＤＲ组的Ｈｃｙ（１３．０１±２．８０）μｍｏｌ·Ｌ－１、ＲＢＰ４（１２．２５±２．４５）μｇ·ｍＬ－１水平明显高于ＮＤＲ组的Ｈｃｙ（６．９９±２．３３）μｍｏｌ·Ｌ－１、ＲＢＰ４（８．８９±１．９０）μｇ·ｍＬ－１，且随着ＤＲ病情的进展逐渐升高，差异均有统计学意义（均为Ｐ＜０．０５）；ＰＤＲ组病程、２ｈＰＧ、ＨｂＡ１ｃ、ＴＧ、ＬＤＬ-Ｃ、Ｈｃｙ、ＲＢＰ４水平明显高于ＮＰＤＲ组、ＮＤＲ组（均为Ｐ＜０．０５）。相关分析显示，２型糖尿病患者的ＲＢＰ４与病程、年龄、ＨｂＡ１ｃ、ＦＰＧ、２ｈＰＧ、ＴＣ、ＴＧ、ＬＤＬ-Ｃ、Ｈｃｙ呈显著正相关，与ＨＤＬ-Ｃ呈负相关。对ＤＲ的危险因素进行多元回归分析结果显示，病程、ＨｂＡ１ｃ、ＲＢＰ４、Ｈｃｙ是影响ＤＲ的主要危险因素。结论　测定Ｈｃｙ及ＲＢＰ４可及早发现ＤＲ，为早期筛查及治疗提供一定的方向。
Abstract:
Objective To investigate the relationship of diabetic retinopathy with homocysteine ( Hcy) and retinol binding protein 4 ( RBP4 ) . Methods A total of 200 T2DM patients were chosen from the Endocrinology Department at Affiliated Hospital of Guilin Medical College during June 2014 and June 2015. According to funds exanunation or fundus fluorescein angiography ( FFA) , all patients were divided into three groups : proliferative diabetic retinopathy ( PDR) group, non-proliferative diabetic retinopathy ( NPDR) group and non-diabetic retinopathy ( NDR) group. All of patients were subjected to measure the fasting postprandial glucose ( FPG ) . 2-hour postprandial glucose (2hPG) , glycosylated hemoglobin ( HbAlc) , lipids , Hcy and RBP4. Results The Hcy and RBP4 levels in PDR group were ( 17. 6 +4. 47) Vmol . L-l and( 16. 32 +3. 57) Vg . mL -1 , NPDR group were ( 13. 01 +2. 8) ymol . L-l and ( 12. 25 +2. 45 ) yg . mL ’l , NDR group were ( 6. 99 +2. 33 ) Vmol . L -l and(8. 89 + 1. 9) Vg . mL ’1 , the Hcy and RBP4 levels gradually increased as DR progressed ( all P < 0. 05 ). The duration and levels of 2hPG , HbAlc , TG , LDL-C , Hcy and RBP4 in PDR group were higher than those in NPDR and NDR groups( all P < 0. 05 ) . Correlation analysis showed that RBP4 were significant positive correlated with duration , age , HbAI c , FPG , 2hPG . TG , TC , LDL- C , Hcy , and was negative correlated with HDL-C ( P < 0. 01 ) . Risk factors for multiple stepwise regression analysis showed that duration , HbAlc , Hcy and RBP4 were major risk factors affecting DR. Conclusion Measuring the Hcy and RBP4 levels can early detect the DR , which provide a certain way for screening and treating.

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备注/Memo

备注/Memo:
广西壮族自治区卫生厅科研课题（编号：Ｚ２０１４５９２）
更新日期/Last Update: 2016-03-08