[1]赵武校,蓝方方,罗妍,等.屈光参差性弱视与屈光参差性近视双眼间高阶像差特征的对比研究[J].眼科新进展,2016,36(2):146-150.[doi:10.13389/j.cnki.rao.2016.0040]
　ZHAO Wu-Xiao,LAN Fang-Fang,LUO Yan,et al.Comparative evaluation of interocular higher order aberrations between anisometropic amblyopia and anisomyopia[J].Recent Advances in Ophthalmology,2016,36(2):146-150.[doi:10.13389/j.cnki.rao.2016.0040]
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屈光参差性弱视与屈光参差性近视双眼间高阶像差特征的对比研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年2期
页码:
146-150
栏目:
应用研究
出版日期:
2016-02-05

文章信息/Info

Title:
Comparative evaluation of interocular higher order aberrations between anisometropic amblyopia and anisomyopia
作者:
赵武校; 蓝方方; 罗妍; 李志超; 甘露; 刘伟民
530021　广西南宁市，广西壮族自治区人民医院视光科　广西视光中心
Author(s):
ZHAO Wu-Xiao;  LAN Fang-Fang ;  LUO Yan;  LI Zhi-Chao;  GAN Lu ;  LIU Wei-Min
Center for Optometry and Visual Science , Department of Optometry , People ’ s Hospital of Guangxi Zhuang Autonomous Region , Nanning 530021 ,Guangxi Zhuang Autonomous Region , China
关键词:
屈光参差性弱视; 屈光参差性近视; 等效离焦度; 高阶像差
Keywords:
anisometropic amblyopia;  anisometropic myopia;  defocus equivalent;  higher order aberration
DOI:
10.13389/j.cnki.rao.2016.0040
文献标志码:
A
摘要:
目的　评估屈光参差性弱视与屈光参差性近视双眼间的高阶像差差异以及双眼间波前像差模式的特征。方法　８５例非斜视性屈光参差患者被纳入本研究并被分成屈光参差性弱视组与屈光参差性近视组。其中屈光参差性弱视组按照最佳矫正视力情况再分为弱视眼和对侧眼亚组，屈光参差性近视组按照屈光度的高低再分为高度数眼和低度数眼亚组。所有患者均接受ＷａｖｅＳｃａｎ波前像差检测。配对ｔ检验用于分析各组内双眼间的差异；Ｓｐｅａｒｍａｎ相关分析和线性回归分析用于分析各亚组内变量间的相互关系。结果　配对ｔ检验与形态分析结果显示：（１）屈光参差性弱视组患者的弱视眼与对侧眼在等效离焦度、最佳矫正视力、总像差、总高阶像差以及三阶像差均方根值等指标上均存在统计学差异（均为Ｐ＜０．０５），形态上双眼间高阶像差呈非对称模式；（２）屈光参差性近视组患者中，仅发现等效离焦度、总像差均方根值两项指标在高度数眼与低度数眼之间存在统计学差异（均为Ｐ＜０．０５），形态上双眼间高阶像差有一定程度的相似性和对称性。Ｓｐｅａｒｍａｎ相关分析显示：（１）屈光参差性弱视组弱视眼等效离焦度与其总像差均方根值（ｒ＝０．８１９，Ｐ＝０．０００）、三阶像差均方根值（ｒ＝－０．３１５，Ｐ＝０．０４８）存在相关性，对侧眼等效离焦度与其总像差均方根值（ｒ＝０．８７６，Ｐ＝０．０００）亦存在相关性；弱视眼等效离焦度与其总像差均方根值的回归方程为ｙ＝２．２７５＋１．０６６ｘ（Ｒ２＝０．６６８，Ｆ＝７６．４４７，Ｐ＝０．０００），对侧眼等效离焦度与其总像差均方根值的回归方程为ｙ＝１．４６２＋１．２１４ｘ（Ｒ２＝０．７２１，Ｆ＝９８．１７０，Ｐ＝０．０００）。（２）屈光参差性近视组高度数眼等效离焦度与其总像差均方根值（ｒ＝０．８５２，Ｐ＝０．０００）、四阶像差均方根值（ｒ＝－０．３１３，Ｐ＝０．０３７）存在相关性，低度数眼等效离焦度与其总像差均方根值（ｒ＝０．９０３，Ｐ＝０．０００）亦存在相关性；高度数眼等效离焦度与其总像差均方根值的回归方程为ｙ＝１．６７１＋１．２０６ｘ（Ｒ２＝０．７９４，Ｆ＝１６６．００５，Ｐ＝０．０００），与四阶像差均方根值的回归方程为ｙ＝０．３１４－０．０２４ｘ（Ｒ２＝０．１１７，Ｆ＝５．７０９，Ｐ＝０．０２１），低度数眼等效离焦度与其总像差均方根值的回归方程为ｙ＝１．０１３＋１．２０９ｘ（Ｒ２＝０．８５１，Ｆ＝２４４．９５７，Ｐ＝０．０００）。结论　双眼间高阶像差在屈光参差性弱视患者中呈非对称模式，在屈光参差性近视患者中则呈相似和对称模式。
Abstract:
Objective To evaluate the interocular differences of higher order aberrations ( HOAs) and resultant bilateral wavefront patterns in anisometropic amblyopia and anisometropic myopia ( anisomyopia) . Methods Eighty-five non-strabismic anisometropes were enrolled and divided into two groups : anisometropic amblyopia group and anisomyopia group. Then anisometropic amblyopia group was divided into amblyopic eye ( AE) and fellow eye ( FE) subgroups according to the best corrected visual acuity ( BCVA) of each subject.and anisomyopia group was divided into more ametropic eye (MAE) and less ametropic eye ( LAE ) subgroups according to the refraction of each subject. A1l patients underwent wavefront analysis on WaveScan WaveFront ~ System ( AMO, USA) . Paired t-test was used to compare interocular differences within groups , and Spearman correlation analysis ,linear regression analysis was applied to explore the interrelation between refraction and wavefront aberrations within groups. Results Paired t-test showed significant differences in defocus equivalent ( DE) .BCVA. total aberration root mean square ( RMS) ,total higher aberration RMS and third aberration RMS between AE and FE subgroups in anisometropic amblyopia ( all P < 0. 05 ) .but no significant differences were noticed in higher order aberration between MAE and LAE subgroups in anisomyopia except for DE and total aberration RMS (P < 0. 05 ) . Pattem analysis indicated that anisometropic amblyopia showed asymmetric pattern in bilateral HOAs, but anisomyopia showed interocular similarity and symmetry in HOAs. Spearman ’ s correlation coefficient demonstrated that in anisometropic amblyopes , significant correlations were observed between DE and RMS of total aberration ( r = 0. 819 . P = 0. 000 ) . and third-order RMS( r = - 0. 315 ,P = 0. 048 ) in AE. And significant correlations were also found between DE and RMS of total aberration ( r = 0. 876 ,P = 0. 000) in FE. The linear regression equation in AE between DE and RMS of total aberration was y = 2. 275 + 1. 066x ( R2 = 0. 668 .F = 76. 447 ,P = 0. 000 ) . The linear regression equation in FE between DE and RMS of total aberration was y = 1. 462 + 1. 214x ( R2 = 0. 721 , F = 98. 170 , P = 0. 000 ) . However , in anisomyopia , significant correlations were observed between DE and RMS of total aberration ( r = 0. 852.P = 0. 000) . and fourth order RMS ( r = - 0. 313 .P = 0. 037) in MAE .and sigruficant correlations were found between DE and RMS of total aberration ( r = 0. 903 .P = 0. 000) in LAE. The linear regression equation in MAE between DE and RMS of total aberration was y = 1. 671 + 1. 206x ( R2 = 0. 794 . F= 166. 005 .P = 0. 000 ) , between DE and fourth order RMS was y = 0. 314 - 0. 024x ( R2 = 0. 117 .F = 5. 709 ,P = 0. 021 ) . The linear regression equation in LAE between DE and RMS of total aberration was y = 1. 013 + 1. 209x ( R2 = 0. 851 .F = 244. 957 . P = 0. 000) . Conclusion Anisometropic amblyopia marufest asymmetric pattern in HOAs between the two eyes , which is different from anisomyopia with interocular similarity and symmetry profiles in HOAs.

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备注/Memo

备注/Memo:
广西壮族自治区卫生厅资助项目（编号： 桂卫Ｚ２０１３３３６）；广西壮族自治区人民医院青年基金项目
更新日期/Last Update: 2016-01-29