[1]陈素芳,李亨辉,邵毅,等.非诺贝特在糖尿病性黄斑水肿中的临床研究[J].眼科新进展,2016,36(2):136-138.[doi:10.13389/j.cnki.rao.2016.0037]
　CHEN Su-Fang,LI Heng-Hui,SHAO Yi,et al.Clinical study of fenofibrate in diabetic macular edema[J].Recent Advances in Ophthalmology,2016,36(2):136-138.[doi:10.13389/j.cnki.rao.2016.0037]
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非诺贝特在糖尿病性黄斑水肿中的临床研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年2期
页码:
136-138
栏目:
应用研究
出版日期:
2016-02-05

文章信息/Info

Title:
Clinical study of fenofibrate in diabetic macular edema
作者:
陈素芳; 李亨辉; 邵毅; 曾莉; 黎明明; 高桂平
330006　江西省南昌市，南昌大学第一附属医院眼科
Author(s):
CHEN Su-Fang ;  LI Heng-Hui; SHAO Yi; ZENG Li; LI Ming-Ming ;  GAO Gui-Ping
Department of Ophthalmology , the First Affiliated Hospital of lVanchang University , Nanchang 330006 , Jiangxi Province , China
关键词:
非诺贝特; 糖尿病性黄斑水肿; 光学相干断层扫描
Keywords:
fenofibrate;  diabetic macular edema;  optical coherence tomography
DOI:
10.13389/j.cnki.rao.2016.0037
文献标志码:
A
摘要:
目的　观察非诺贝特在视网膜光凝后糖尿病性黄斑水肿（ｄｉａｂｅｔｉｃｍａｃ-ｕｌａｒｅｄｅｍａ，ＤＭＥ）中的疗效。方法　观察３８例（６７眼）已完成视网膜光凝的ＤＭＥ患者，其中１５例（２３眼）为增生型糖尿病性视网膜病变，２３例（４４眼）为非增生型糖尿病性视网膜病变；随机分为两组，其中Ａ组２０例（３５眼）口服非诺贝特＋复方血栓通胶囊，Ｂ组１８例（３２眼）单独口服复方血栓通胶囊，两组均连续服药２８ｄ，２８ｄ后采用光学相干断层扫描随诊观察两组黄斑中心凹视网膜平均厚度（ａｖｅｒａｇｅｆｏｖｅａｌｒｅｔｉｎａｌｔｈｉｃｋｎｅｓｓ，ＡＦＲＴ）、平均黄斑容积（ａｖｅｒａｇｅｍａｃｕｌａｒｖｏｌ-ｕｍｅ，ＡＭＶ）、黄斑区视网膜平均厚度（ａｖｅｒａｇｅｍａｃｕｌａｒｔｈｉｃｋｎｅｓｓ，ＡＭＴ），并观察两组视力情况。结果　用药２８ｄ后，在视力改善方面Ａ组优于Ｂ组，差异有统计学意义（Ｐ＜０．０５）；Ａ组ＡＦＲＴ、ＡＭＶ、ＡＭＴ均较用药前明显减少，差异均有统计学意义（均为Ｐ＜０．０５）；Ｂ组ＡＦＲＴ、ＡＭＶ、ＡＭＴ均较用药前稍有增加，差异均有统计学意义（均为Ｐ＜０．０５）；Ａ组患者用药后黄斑水肿消退各指标（ＡＦＲＴ、ＡＭＶ、ＡＭＴ）较Ｂ组明显减少，差异均有统计学意义（均为Ｐ＜０．０５）。结论　非诺贝特能改善ＤＭＥ患者视力，有效促进视网膜光凝后黄斑水肿的吸收。
Abstract:
Objective To investigate the efficacy of fenofibrate in diabetic macular edema ( DME) after retinal photocoagulation. Methods The randonuzed controlled study included 38 DME patients ( 67 eyes) who completed retinal photocoagulation, including 15 patients ( 23 eyes) of proliferative diabetic retinopathy ( PDR) and 23 patients ( 44 eyes) of non-proliferation diabetic retinopathy ( NPDR) . Patients were randomized into two groups : fenofibrate and Xueshuangtong capsule administered to group A ( 20 cases,35 eyes) and only Xueshuangtong capsule administered to group B ( 18 cases,32 eyes) for 28 days. After 28 days, the average foveal retinal thickness ( AFRT) . average macular volume ( AMV) , average macular thickness ( AMT) were observed by optical coherence tomography, and the corrected visual acuity was also observed. Results After 28d treatment, group A achieved better visual acuity than group B, the difference was statistically significant (P < 0. 05 ) ; In the group A , AFRT .AMV . AMT were less than before treatment , the difference was statistically significant( all P < 0. 05 ) ; In the group B, AFRT, AMV. AMT were more than before treatment .the difference was statistically sigruficant ( all P < 0. 05 ) . After 28d treatment . there were significantly difference in AFRT . AMV . AMT between two groups ( all P < 0. 05 ) . Conclusion Fenofibrate can improve visual acuity and effectively promote the absorption of DME after retinal photocoagulation.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号： ８１１６０１１８、８１４００３７２）；全国临床医药研究专项基金（编号：Ｌ２０１２０５２）；江西省远航工程（编号：２０１４０２２）；江西省学位与研究生教育教学改革研究项目（编号：２０１５）；江西省科技平台建设项目（编号：２０１３１１６）；江西省青年科学基金（编号：２０１５１ＢＡＢ２１５０１６）；江西省科技支撑计划项目（编号：２０１５１ＢＢＧ７０２２３）；江西省教育厅科技计划项目（编号：ＧＪＪ１４１７０）；江西省卫计委科技计划项目（编号：２０１５５１５４）；赣江学者计划（２０１５）
更新日期/Last Update: 2016-01-29