[1]罗毅,祁勇军,赵燕.原发性开角型青光眼患者视网膜神经纤维层厚度与视野缺损的相关性研究[J].眼科新进展,2015,35(11):1054-1056.[doi:10.13389/j.cnki.rao.2015.0288]
　LUO Yi,Ql Yong-Jun,ZHAO Yan.Correlation between RNFL thickness and visual field defect in primary open-angle glaucoma patients[J].Recent Advances in Ophthalmology,2015,35(11):1054-1056.[doi:10.13389/j.cnki.rao.2015.0288]
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原发性开角型青光眼患者视网膜神经纤维层厚度与视野缺损的相关性研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年11期
页码:
1054-1056
栏目:
应用研究
出版日期:
2015-11-05

文章信息/Info

Title:
Correlation between RNFL thickness and visual field defect in primary open-angle glaucoma patients
作者:
罗毅; 祁勇军; 赵燕
430000　湖北省武汉市，华中科技大学同济医学院附属普爱医院眼科
Author(s):
LUO Yi;  Ql Yong-Jun; ZHAO Yan
Department of Ophthalmology , Puai Hospital Affiliated to Tongji Medical College , Huazhong University of Science and Technology. Wuhan 430000 , Hubei Province . China
关键词:
原发性开角型青光眼; 视网膜神经纤维层; 视野缺损; 光学相干断层扫描
Keywords:
primary open angle glaucoma; retinal nerve fiber layer; visual field defect ;  optical coherence tomography
DOI:
10.13389/j.cnki.rao.2015.0288
文献标志码:
A
摘要:
目的　探讨原发性开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）患者视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙｅｒ，ＲＮＦＬ）厚度与视野缺损的相关性。方法　选取２０１３年４月至２０１４年５月我院收治的３０例（３０眼）ＰＯＡＧ患者作为观察组，另选取同期于我院体检的３０名健康者作为对照组，检测两组受试者的ＲＮＦＬ厚度及视野缺损情况。结果　观察组上方、下方、颞侧、鼻侧四个象限的ＲＮＦＬ厚度分别为（９２．５３±１０．７２）μｍ、（９１．４８±１１．４５）μｍ、（７４．６８±８．３３）μｍ、（７１．４５±９．１５）μｍ，对照组分别为（１４１．６７±１９．４５）μｍ、（１３７．６１±１８．４６）μｍ、（９４．５５±１１．６４）μｍ、（９０．４９±１０．４８）μｍ，差异均有统计学意义（均为Ｐ＜０．０５）；观察组上方、下方、颞侧、鼻侧四个象限的视野缺损值分别为（６．４９±０．８４）ｄＢ、（５．９１±０．６９）ｄＢ、（８．４２±０．９５）ｄＢ、（７．２９±０．９４）ｄＢ。相关性分析显示，观察组ＲＮＦＬ厚度与各相应视野内的视野缺损呈负相关，回归系数ｂ的差异均有统计学意义（均为Ｐ＜０．０５）。结论　ＰＯＡＧ患者存在ＲＮＦＬ损伤及视野缺损，且二者具有负相关性，能够准确判断病情。
Abstract:
Objective To study the correlation between retinal nerve fiber layer ( RNFL) thickness and visual field defect in primary open-angle glaucoma( POAG) patients. Methods Thirty patients(30 eyes) with POAG in our hospital from April 2013 to May 2014 were enrolled in observation group , and 30 healthy subjects received physical exanunation over the same period were enrolled in control group. Then RNFL thickness.and visual field defect were detected. Results RNFL thickness of upper visual field.lower visual field, temporal visual field, nasal visual field in observation group were ( 92. 53 + 10. 72) ym, (91. 48 + 11. 45 ) ym, ( 74. 68 + 8. 33 ) ym and (71. 45 + 9. 15 ) ym , respectively , which in control group were ( 141. 67 + 19. 45 ) Vm , ( 137. 61 + 18. 46 ) ym , ( 94. 55 + 11. 64 ) p m and ( 90. 49 + 10. 48 ) p m, respectively , there were statistical difference between two groups ( all P < 0. 05 ) . The visual field defect value of upper visual field ,lower visual field . temporal visual field . nasal visual field in observation group were (6. 49 +0. 84) dB . ( 5. 91 +0. 69) dB , ( 8. 42 +0. 95 ) dB and ( 7. 29 + 0. 94 ) dB. RNFL thickness was negatively correlated with visual field defect in corresponding fields in observation group ( all P < 0. 05 ) . Conclusion POAG patients exist RNFL damage and visual field defect . and RNFL thickness is negativeky correlation with visual field defect. they can accurately judge the disease condition.

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备注/Memo

备注/Memo:
武汉市临床医学科研项目（编号：ＷＺ１４Ｂ０８）
更新日期/Last Update: 2015-11-03