[1]万文萃,刘宇莹,尹向可,等. 玻璃体内注射抗血管内皮生长因子药物治疗急进性后部型早产儿视网膜病变[J].眼科新进展,2015,35(6):554-557.[doi:10.13389/j.cnki.rao.2015.0150]
　WAN Wen-Cui,LIU Yu-Ying,YIN Xiang-Ke,et al. Intravitreal injection of ranibizumab for aggressive posterior retinopathy of prematurity[J].Recent Advances in Ophthalmology,2015,35(6):554-557.[doi:10.13389/j.cnki.rao.2015.0150]
点击复制

 玻璃体内注射抗血管内皮生长因子药物治疗急进性后部型早产儿视网膜病变
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年6期
页码:
554-557
栏目:
应用研究
出版日期:
2015-06-05

文章信息/Info

Title:
 Intravitreal injection of ranibizumab for aggressive posterior retinopathy of prematurity
作者:
 万文萃; 刘宇莹; 尹向可; 杨果果; 荣军博; 金学民
 450052　河南省郑州市，郑州大学第一附属医院眼科
Author(s):
 WAN Wen-Cui;  LIU Yu-Ying;  YIN Xiang-Ke;  YANG Guo-Guo;  RONG Jun-Bo ; JIN Xue-Min
 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052 . Henan Province . China
关键词:
 ; 急进性后部型早产儿视网膜病变; 雷珠单抗; 玻璃体内注射
Keywords:
 ; aggressive posterior retinopathy of prematurity ;  ranibizumab ;  intravitreal inj ection
DOI:
10.13389/j.cnki.rao.2015.0150
文献标志码:
A
摘要:
 目的　观察玻璃体内注射雷珠单抗（商品名Ｌｕｃｅｎｔｉｓ）治疗急进性后部型早产儿视网膜病变（ａｇｇｒｅｓｓｉｖｅｐｏｓｔｅｒｉｏｒｒｅｔｉｎｏｐａｔｈｙｏｆｐｒｅｍａｔｕｒｉｔｙ，ＡＰ-ＲＯＰ）的疗效。方法　将自２０１４年３月至１２月我院经广角照相系统（ｒｅｔｃａｍⅢ）行ＲＯＰ筛查后诊断为ＡＰ-ＲＯＰ的２６例３６眼纳入研究。所有患眼均行玻璃体内注射雷珠单抗（０．０５ｍＬ）治疗，治疗后随访６个月，观察视网膜病变转归情况。结果　３６眼中病变位于１区者２０眼，病变位于２区者１６眼；合并虹膜新生血管者２眼，合并玻璃体积血者１０眼。玻璃体内注射雷珠单抗后，未见角膜水肿、晶状体混浊、眼内炎等眼部并发症及全身不良反应发生。行一次玻璃体内注射治愈者３２眼，治愈率为８８．８９％。玻璃体内注射雷珠单抗后１周内，合并虹膜新生血管的２眼新生血管均消退。２眼发生牵引性视网膜脱离，行玻璃体切割术治疗。结论　玻璃体内注射雷珠单抗治疗ＡＰ-ＲＯＰ安全、有效。
Abstract:
 Objective To observe the efficacy of intravitreal injection of ranibizumab for aggressive posterior retinopathy of prematurity ( AP-ROP) . Methods Medical records of 36 eyes of 26 premature infants with a primary diagnosis of AP-ROP in our clinic were reviewed and analyzed retrospectively. A1l affected eyes were treated with intravitreal injection of rarubizumab ( 0. 05 mL) . Follow-up averaged 6 months. The anatomical results and complications were evaluated after treatment. Results All the lesions of 36 eyes were located in posterior zone.with 20 eyes in zone I and 16 eyes in zone 2. Two eyes had iris neovascularization.while 10 eyes combined with vitreous hemorrhage. No major systemic or ocular complications after injection appeared. All lens remained transparent and no iatrogenic retinal hole was occurred during the follow-up. 32 eyes were cured for only one time.the cured rate was 88. 8g% ( 32/36) . After the injection,the regression of iris neovascularization was observed in 2 eyes within I week. However,2 eyes had retinal detachment . and the vitrectomy was given. Conclusion Intravitreal injection of ranibizumab is safe and effective in the treatment of AP-ROP.

相似文献/References:

[1]刘平 苏胜. 白内障蛋白质组学研究的现状及未来研究方向[J].眼科新进展,2014,34(1):001.
[2]杨宝娣 宋艳萍 陈中山 丁琴. 微脉冲半导体激光对兔视网膜色素上皮细胞阈值下光凝的光生物调制效应[J].眼科新进展,2014,34(1):005.
[3]赖伟霞 梁皓 谭少健 李霞 邹文进 蒋林志. 钙调素在正常人及不同年龄白内障患者晶状体上皮细胞中的表达[J].眼科新进展,2014,34(1):010.
[4]郑燕林 刘聪慧 沙菽. 水蛭提取液对体外培养RF/6A的细胞液中MMP-2、IV型胶原含量的影响[J].眼科新进展,2014,34(1):013.
[5]周琨 高晓唯 蔡岩 李文静 胡裕坤 田丽丽 付燕. CCR7基因修饰的未成熟树突状细胞在大鼠高危角膜移植免疫排斥反应中的作用[J].眼科新进展,2014,34(1):017.
[6]高伟 程燕 吴洁 王亮 赵帅. 肉毒杆菌B诱导大鼠干眼模型中泪腺Lacritin蛋白表达的研究[J].眼科新进展,2014,34(1):021.
[7]赵宁 张瑞君 刘磊 李佳 刘宁宁. PTEN基因对兔晶状体上皮细胞增殖抑制作用的实验研究[J].眼科新进展,2014,34(1):025.
[8]陈雪 李海平 张培 曹安民. 小胶质细胞在视网膜母细胞瘤中的活化及分布研究[J].眼科新进展,2014,34(1):029.
[9]李琴 谢婷玉 陈雪艺 王清 郭乔茜 具尔提·哈第尔. 臭氧灌肠改善糖尿病大鼠的视网膜电图表现[J].眼科新进展,2014,34(1):034.
[10]蔡晶晶 孟倩丽 郭海科 张良 李东风 崔颖. 血红素加氧酶-1在糖尿病视网膜病变患者外周血单个核细胞中的表达[J].眼科新进展,2014,34(1):037.

备注/Memo

备注/Memo:
 河南省科技攻关项目资助（编号：１２２１０２３１０２２７）
更新日期/Last Update: 2015-06-01