[1]王宗华,李秋平,白华,等. 早产儿视网膜病变自然消退和进展的影响因素研究[J].眼科新进展,2015,35(2):168-170.[doi:10.13389/j.cnki.rao.2015.0045]
　WANG Zong-Hua,LI Qiu-Ping,BAI Hua,et al. Influencing factors of spontaneous regression and progression of retinopathy of prematurity[J].Recent Advances in Ophthalmology,2015,35(2):168-170.[doi:10.13389/j.cnki.rao.2015.0045]
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 早产儿视网膜病变自然消退和进展的影响因素研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年2期
页码:
168-170
栏目:
应用研究
出版日期:
2015-02-05

文章信息/Info

Title:
 Influencing factors of spontaneous regression and progression of retinopathy of prematurity
作者:
 王宗华; 李秋平; 白华; 张惠敏; 赵烨
 100700　北京市，北京军区总医院眼科
Author(s):
 WANG Zong-Hua ;  LI Qiu-Ping ;  BAI Hua ;  ZHANG Hui-Min ;  ZHAO Ye
 Department of Ophthalmology , General Hospital of Beijing Military Command of People ’s Liberation Army , Beijing 100700 , China
关键词:
 ; 早产儿视网膜病变; 危险因素; 转归
Keywords:
 ; retinopathy of prematurity ;  risk factors ;  prognosis
DOI:
10.13389/j.cnki.rao.2015.0045
文献标志码:
A
摘要:
 目的　分析早产儿视网膜病变（ｒｅｔｉｎｏｐａｔｈｙｏｆｐｒｅｍａｔｕｒｉｔｙ，ＲＯＰ）的自然消退和进展情况及相关因素，了解影响ＲＯＰ病变进展的因素。方法　回顾分析我院２０１２年１月至１２月１８９例ＲＯＰ患儿，根据预后分为进展组和消退组，对两组出生胎龄、出生体质量、机械通气时间等相关因素进行统计学分析。结果　１８９例ＲＯＰ患儿中，５８例（３０．６９％）ＲＯＰ进展至重度需手术治疗，１３１例（６９．３１％）患儿病变自然消退。进展组出生胎龄（２８．６６±１．８３）周、出生体质量（１１８４．４４±２８１．２０）ｇ，与消退组患儿胎龄（２８．９７±１．７８）周、出生体质量（１２５０．１２±２８７.９８）ｇ比较，差异均无统计学意义（均为Ｐ＞０．０５）。ＲＯＰ病变进展与多胎、机械通气时间、出生后１ｍｉｎ和５ｍｉｎＡｐｇａｒ评分相关性显著（均为Ｐ＜０．０５）；而与性别、贫血、动脉导管未闭、脑炎、败血症、呼吸窘迫综合征、应用激素、肺表面活性剂应用、输血治疗无显著相关性（均为Ｐ＞０．０５）。多因素Ｌｏｇｉｓｔｉｃ回归分析显示，长时间机械通气是ＲＯＰ病变进展的危险因素（χ２ ＝７３.６２３，Ｐ＝０．００３）。结论　ＲＯＰ大部分可自行消退，长时间机械通气可加重病情，对早产儿及ＲＯＰ患儿应严格把握吸氧浓度和用氧时间，有效阻止ＲＯＰ病变进展，降低发生重症ＲＯＰ的危险性。
Abstract:
 Objective To analyze the possible relative factors of spontaneous regression and progression of retinopathy of prematurity ( ROP) , and identify the risk factors of ROP. Methods This was a retrospective , hospital-based study. The prognosis of 189 infants diagnosed as ROP in our hospital from January 2012 to December 2012 was recorded. In all patients , gestational weeks , birth weight , time of oxygen by mechanical ventilation and other risk factors for ROP were also analyzed. Results Fifty-eight ( 30. 6g% ) infants of ROP undergone surgery and 131 (69. 31% ) infants regressed completely. The gestional age and birth weight of the progress group were (28. 66 + 1. 83 ) weeks and ( 1184. 44 + 281. 20 ) g , which of the regress group were ( 28. 97 + 1. 78 ) weeks and ( 1250. 12 +287. 98) g , the difference was not significant ( all P > 0. 05 ) . The difference in multiple gestational birth. mechanical ventilation duration, 1-nunute Apgar score.5-minute Apgar score were statistically sigruficant between the two groups ( aU P < 0. 05 ) . The difference in sex. anaemia, patent ductus arteriosus. meningitis , septemia, respiratory distress syndrome, dexamethasone treatment. surfactant treatment. blood transfusion was no statistically significant between the two groups ( all P > 0. 05) . Logistic regressrve analysis indicated that mechanical ventilation duration was the risk factor of ROP progress (X2 =73. 623 .P =0. 003) . Conclusion Most of ROP can spontaneously regress without surgery. ROP with long time of mechanical ventilation can progress and need surgery. For infants with ROP.we should shorten the time of mechanical ventilation. That should be helpful to prevent the progress of ROP and spontaneously regress.

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更新日期/Last Update: 2015-02-03