[1]李志萍,吴焕卿,陈惠军.早产儿视网膜病变患儿血清谷氨酸浓度变化及其相关关系[J].眼科新进展,2014,34(8):782-784.[doi:10.13389/j.cnki.rao.2014.0216]
　Li Zhi-Ping,WU Huan-Qing,CHEN Hui-Jun.Changes of glutamate in serum of patients with retinopathy of prematurity and their correlation[J].Recent Advances in Ophthalmology,2014,34(8):782-784.[doi:10.13389/j.cnki.rao.2014.0216]
点击复制

早产儿视网膜病变患儿血清谷氨酸浓度变化及其相关关系
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年8期
页码:
782-784
栏目:
应用研究
出版日期:
2014-08-05

文章信息/Info

Title:
Changes of glutamate in serum of patients with retinopathy of prematurity and their correlation
作者:
李志萍; 吴焕卿; 陈惠军
河南省新乡市，新乡市中心医院儿内科
Author(s):
Li Zhi-Ping; WU Huan-Qing; CHEN Hui-Jun
关键词:
早产儿视网膜病变; 谷氨酸; 酶联免疫吸附试验
Keywords:
retinopathy of prematurity ;  glutamate ;  ELISA
DOI:
10.13389/j.cnki.rao.2014.0216
文献标志码:
A
摘要:
目的　探讨早产儿视网膜病变（ｒｅｔｉｎｏｐａｔｈｙｏｆｐｒｅｍａｔｕｒｉｔｙ，ＲＯＰ）患儿血清谷氨酸浓度变化及其与ＲＯＰ的相关关系。方法　选取２００９年１月至２０１３年７月我院收治的１００例早产儿为研究对象，所有患儿均接受ＲＯＰ筛查，并分别于生后７ｄ、４２ｄ进行外周血谷氨酸浓度测定。结果　根据筛查结果分为３组，Ⅰ组为轻度ＲＯＰ（Ⅰ －Ⅱ期）共３６例，Ⅱ组为重度ＲＯＰ（Ⅲ －Ⅴ期）共１８例，Ⅲ组为未发生ＲＯＰ的早产儿共４６例。生后７ｄⅢ组与Ⅰ组血清谷氨酸浓度分别为（６９．３４８±２５．７６８）ｍｍｏｌ?Ｌ－１、（８４．２７８±３０．０８９）ｍｍｏｌ?Ｌ－１，差异有统计学意义（Ｐ＜０．０５）；Ⅲ组与Ⅱ组血清谷氨酸浓度（１２２．２２２±４２．５０３）ｍｍｏｌ?Ｌ－１比较，差异有显著统计学意义（Ｐ＜０．００１）；Ⅰ组与Ⅱ组血清谷氨酸浓度比较，差异有统计学意义（Ｐ＜０．０５）。生后４２ｄⅠ组与Ⅱ组血清谷氨酸浓度比较，差异有统计学意义（Ｐ＜０．０５）。血清谷氨酸升高与ＲＯＰ呈正相关（ｒ＝０．９７１６，Ｐ＜０．０５）。结论　ＲＯＰ患儿血清谷氨酸浓度越高，病情越重，抑制谷氨酸浓度升高可能会预防和减轻ＲＯＰ的发生发展。
Abstract:
Objective To deternune the serum level of glutamate ( GLU ) in patients with retinopathy of prematurity ( ROP) and their correlation. Methods One hundred cases of prematurity were chosen. all newborn infants received the ROP screerung , and the GLU concentration in serum was detected at postnatal 7 day and 42 days. Results Based on the screening of ROP. the infants were divided into three groups , group I was mild ROP in 26 cases , group II was server ROP ( stage III - lV ) in 18 cases ,group JII was non( ROP in 46 cases. The GLU concentration in serum of group I . n and m at postnatal 7 days were ( 84. 178 + 30. 089 ) mmol . L". ( 122. 222 +42. 503 ) mmol . L - l and ( 69. 348 + 25. 768 ) mmol . L ’1 , respectively , there were statistical differences between group I and III ,group I and n ( all P < 0. 05 ) , and significant difference between group n and III (P < 0. 001) . There was statistical difference in GLU concentration at postoperative 42 days between group I and II (P < 0. 05 ) . The increases of GLU concentration in serum was positive correlated with ROP ( r = 0. 9716 ,P <0. 05 ) . Conclusion The higher GLU level in serum is .the more severe the illness will be , and inhibition of GLU level can prevent and reduce the occurrence and development of ROP.

相似文献/References:

[1]胡丽荣 肖倩 王景春 李金明 杨峰 张爱军 王福海.盐酸美金刚对兔受损视神经的保护作用[J].眼科新进展,2012,32(7):000.
[2]杜安杰 任兵 高晓唯 付燕 赵旭东 郭继华.氨基胍对氧诱导的视网膜病变小鼠视网膜神经细胞的保护作用[J].眼科新进展,2012,32(12):000.
[3]王宗华 董文丽 陈思扬.早产儿视网膜病变间接检眼镜激光治疗及危险因素分析[J].眼科新进展,2012,32(12):000.
[4]田妮 郭海科 项道满 陈锋 卢艳华.数字化双目间接检眼镜检查系统在早产儿视网膜病变筛查中的应用[J].眼科新进展,2012,32(12):000.
[5]喻小龙 谭钢 刘二华 周寿红.罗格列酮对高糖诱导视网膜神经节细胞损伤的保护作用[J].眼科新进展,2013,33(2):000.
[6]马殿伟 谢学军 张梅 万李.补肾活血剂对TGF-β2干预缺氧状态下视网膜Müller细胞谷氨酸代谢的影响[J].眼科新进展,2013,33(9):000.
[7]黄正如 陈海英 徐 明 陆 炯 叶 凯 管怀进.span style="font-size: 12pt; color: black; font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA; mso-bidi-font-family: 'Times New Roma[J].眼科新进展,2008,28(9):000.
[8]李蓉 王雨生.早期治疗早产儿视网膜病变的多中心临床试验[J].眼科新进展,2012,32(3):000.
[9]彭娟 沙翔垠 杨瑞明 郑瑜.妊娠并发症及围产期感染与早产儿视网膜病变的关系[J].眼科新进展,2012,32(4):000.
[10]王淋淋 唐兰芬 谭建新 阮豫才 方玉兰.曲尼司特抑制早产儿视网膜病变大鼠模型血管新生和纤维化的实验研究[J].眼科新进展,2013,33(10):000.

更新日期/Last Update: 2014-07-30