[1]杨玉洁,杨永利,徐春丽,等.糖尿病对后发性白内障的影响及可能机制的初步研究[J].眼科新进展,2014,34(5):474-477.[doi:10.13389/j.cnki.rao.2014.0130]
　YANG Yu-Jie,YANG Yong-Li,XU Chun-Li,et al.Effects of diabetes mellitus on posterior capsule opacification and its possible mechanism[J].Recent Advances in Ophthalmology,2014,34(5):474-477.[doi:10.13389/j.cnki.rao.2014.0130]
点击复制

糖尿病对后发性白内障的影响及可能机制的初步研究
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年5期
页码:
474-477
栏目:
应用研究
出版日期:
2014-05-05

文章信息/Info

Title:
Effects of diabetes mellitus on posterior capsule opacification and its possible mechanism
作者:
杨玉洁; 杨永利; 徐春丽; 谢铃; 蔡岩; 孙秋萍; 李林
８３００１１新疆维吾尔自治区乌鲁木齐市，解放军第４７４医院眼科医院、全军眼科中心
Author(s):
YANG Yu-Jie ;  YANG Yong-Li; XU Chun-Li ;  XIE Ling ; CAl Yan ;  SUN Qiu-Ping ;  LI Lin
关键词:
糖尿病; 后发性白内障; 白细胞介素-６; 房水
Keywords:
diabetes mellitus ;  posterior capsule opacification ;  interleukin-6 ;  aqueous humor
DOI:
10.13389/j.cnki.rao.2014.0130
文献标志码:
A
摘要:
目的　探讨２型糖尿病对后发性白内障的影响及其可能的分子机制。方法　收集１０８例（１０８眼）白内障患者房水并行ＥＬＩＳＡ检测房水中ＩＬ-６含量，其中对照组（年龄相关性白内障患者）５０例（５０眼），试验组（２型糖尿病白内障患者）５８例（５８ 眼），比较两组最佳矫正视力、眼压、后发性白内障（ｐｏｓｔｅｒｉｏｒｃａｐｓｕｌｅｏｐａｃｉｆｉｃａｔｉｏｎ，ＰＣＯ）发生率、ＰＣＯ严重程度、房水中ＩＬ-６含量等。结果　白内障超声乳化联合人工晶状体植入术均提高了两组患者术后最佳矫正视力，且对照组较试验组最佳矫正视力提高明显（Ｐ＝０．００２）。对照组术前、术后眼压分别为（１３．９３±３．２５）ｍｍＨｇ（１ｋＰａ＝７．５ｍｍＨｇ）、（１４．６０±４．３５）ｍｍＨｇ，差异无统计学意义（Ｐ＞００５）；试验组术前、术后眼压分别为（１４．１８±３．５６）ｍｍＨｇ、（１５．１２±４．６６）ｍｍＨｇ，差异无统计学意义（Ｐ＞ ００５）。对照组ＰＣＯ发生率２６．００％，试验组ＰＣＯ发生率４１．３８％，两组间ＰＣＯ发生率差异无统计学意义（Ｐ＝０．０９５）。试验组房水中ＩＬ-６含量与后发性白内障呈正相关（ｒ＝０７３１，Ｐ＝０００１），且试验组房水中ＩＬ-６含量较对照组明显升高（Ｐ＝００１２）。结论　房水中ＩＬ-６含量可能促进了糖尿病患者ＰＣＯ的发生发展，其具体机制尚需进一步研究。
Abstract:
Objective To detect the effects of diabetes mellitus ( DM) on the posterior capsule opacification ( PCO) and the underlying molecular mechanisms. Methods Fifty-eight eyes of 58 consecutive type 2 diabetes mellitus patients ( DM group) and 50 eyes of 50 non-DM patients with age-related cataract ( control group) were enrolled. Aqueous humor was collected at the start of cataract surgery and concentration of interleukin-6 ( IL-6) in aqueous humor was exanuned by ELISA. The best corrected visual acuity ( BCVA) and intraocular pressure ( IOP) were examined before and after operation. The severity of posterior capsule opacification was deternuned. Resrilts BCVA increased in both two groups after cataract surgery, and the postoperative BCVA in control group was better than that in DM group (P = 0. 002) . The preoperative and postoperative IOP in control group were ( 13. 93 + 3. 25 ) mmHg ( I kPa = 7. 5 mmHg) and ( 14. 60 + 4. 35 ) mmHg, respectively, there was no statistical difference ( P >0. 05 ) .which in DM group were ( 14. 18 + 3. 56 ) mmHg and ( 15. 12 +4. 66 ) mmHg , respectively , there was no statistical difference ( P > 0. 05 ) . The incidences of PCO in control group and DM group were 26. 00% and 41. 37% , respectively, there was no statistical difference (P = 0. 095 ) . The concentration of IL-6 in aqueous humor of DM groups was positive correlated with PCO (R = 0. 731 ,P = 0. 001 ) , and the concentration of IL-6 on DM group was higher than that in control group (P = 0. 012) . Conclusion IL-6 in aqueous humor may play a role in PCO development of DM patients , and the underlying molecular mechanisms should be further investigated.

相似文献/References:

[1]丁文君 韦琦 梁皓 陈金卯 李霞 谭少健.糖尿病兔后发性白内障发生过程中晶状体上皮细胞增殖的变化[J].眼科新进展,2012,32(1):000.
[2]陈放 徐珊 吕伟红 程宏 张洪泉.糖尿病大鼠视网膜的氧化应激损伤及葛根素对其的干预作用[J].眼科新进展,2012,32(1):000.
[3]李晓艳 张卯年.褪黑素对糖尿病大鼠早期视网膜神经细胞凋亡的影响[J].眼科新进展,2012,32(6):000.
[4]唐东永 李霞 梁皓 何剑 谭少健.应用超声生物显微镜观察Bigbag人工晶状体在高度近视眼囊袋内的稳定性[J].眼科新进展,2013,33(6):000.
[5]楚静 陈忠平.普拉洛芬及羟苯磺酸钙在糖尿病患者白内障手术中的应用[J].眼科新进展,2013,33(8):000.
[6]张曙光 何跃 项杰 马林昆 李燕 袁援生.JNK2在早期糖尿病小鼠视网膜中的表达及作用[J].眼科新进展,2012,32(4):000.
[7]李艳 潘斌 李筱荣 袁佳琴 张杰.糖尿病大鼠视网膜PEDF表达与神经退行性改变[J].眼科新进展,2012,32(8):000.
[8]崔颖 郭海科 韩云飞 孟倩丽 张良 尹东明.2型糖尿病住院患者糖尿病视网膜病变患病率及危险因素分析[J].眼科新进展,2012,32(8):000.
[9]张谊 宋光辉 杨架林 张钰 肖强 潘璐 赵伟红 刘昊.糖尿病患者短期内血糖变化对黄斑区视网膜厚度的影响[J].眼科新进展,2012,32(10):000.
[10]刘苹 康刚劲.细胞因子在后发性白内障发病机制中的研究进展[J].眼科新进展,2013,33(3):000.
[11]林凤彬,谭少健,梁皓,等.去整合素echistatin对糖尿病兔后发性白内障形成中信号通路PI3-K/Akt和ERK1/2的影响[J].眼科新进展,2016,36(5):406.[doi:10.13389/j.cnki.rao.2016.0109]
　LIN Feng-Bin,TAN Shao-Jian,LIANG Hao,et al.Effects of disintegrin echistatin on PI3-K/Akt and ERK1/2 signaling pathways in posterior capsule opacification model of diabetic rabbit[J].Recent Advances in Ophthalmology,2016,36(5):406.[doi:10.13389/j.cnki.rao.2016.0109]

更新日期/Last Update: 2014-05-04