[1]李文慧,赵宇辉,毕宏生,等.肠道微生物和眼科疾病相关性的研究现状[J].眼科新进展,2024,44(5):401-404.[doi:10.13389/j.cnki.rao.2024.0078]
　LI Wenhui,ZHAO Yuhui,BI Hongsheng,et al.Current status of research on the correlation between gut microbes and ophthalmic diseases[J].Recent Advances in Ophthalmology,2024,44(5):401-404.[doi:10.13389/j.cnki.rao.2024.0078]
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肠道微生物和眼科疾病相关性的研究现状/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
44卷
期数:
2024年5期
页码:
401-404
栏目:
文献综述
出版日期:
2024-04-30

文章信息/Info

Title:
Current status of research on the correlation between gut microbes and ophthalmic diseases
作者:
李文慧; 赵宇辉; 毕宏生; 田庆梅; 解孝锋
250014　山东省济南市，山东中医药大学（李文慧，赵宇辉，毕宏生，田庆梅，解孝锋）；250002　山东省济南市，山东中医药大学附属眼科医院，山东省中西医结合眼病防治重点实验室，山东省眼病防治研究院，山东省眼视光与青少年视力低下防控临床医学研究中心（毕宏生，田庆梅，解孝锋）
Author(s):
LI Wenhui1; ZHAO Yuhui1; BI Hongsheng1; 2; TIAN Qingmei1; 2; XIE Xiaofeng1; 2
1.Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong
2.Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Shandong Academy of Eye Disease Prevention and Therapy，Shandong Provincial Clinical Medicine Research Center of Optometry and Adolescent Low Vision Prevention and Control,Jinan 250002,Shandong
关键词:
肠道微生物; 干眼症; 葡萄膜炎; 糖尿病性视网膜病变; 青光眼; 年龄相关性黄斑变性
Keywords:
gut microbes;  dry eye;  uveitis;  diabetic retinopathy;  glaucoma;  age-related macular degeneration
分类号:
R77
DOI:
10.13389/j.cnki.rao.2024.0078
文献标志码:
A
摘要:
肠道微生物是寄生在人体肠道内数万亿的复杂的生态群落，通过其集体代谢活动和宿主的相互作用，影响宿主的正常生理活动和疾病易感性。肠道微生物参与机体免疫调节和营养代谢，并与衰老密切相关。近年来，肠道微生物在眼科疾病中的作用也受到了人们的广泛关注。本文对肠道微生物与不同眼科疾病的关系进行综述，以期为眼科疾病的诊断与治疗提供新思路。
Abstract:
Trillions of microbes inhabit the human intestinal tract as a complex ecological community. They impact the host’s normal physiological activities and disease susceptibility through their collective metabolic activities and interactions with the host. Gut microbes participate in immune regulation and nutrient metabolism and are closely related to aging. In recent years, the role of gut microbes in ophthalmic diseases has received much attention. This paper reviews the relationship between gut microbes and various ophthalmic diseases, aiming to provide new insights into the diagnosis and treatment of ophthalmic diseases.

参考文献/References:

［1］　ZHAO Q,ELSON C O.Adaptive immune education by gut microbiota antigens［J］.Immunology,2018,154(1):28-37.
［2］　HORAI R,CASPI R R.Microbiome and autoimmune uveitis［J］.Front Immunol,2019,10:232.
［3］　TREMLETT H,BAUER K C,APPEL-CRESSWELL S,FINLAY B B,WAUBANT E.The gut microbiome in human neurological disease:a review［J］.Ann Neurol,2017,81(3):369-382.
［4］　JIAO X,PEI X,LU D,QI D,HUANG S,HE S,et al.Microbial reconstitution improves aging-driven lacrimal gland circadian dysfunction［J］.Am J Pathol,2021,191(12):2091-2116.
［5］　QI D,ZOU S,LU D,PEI X,HUANG S,HUANG D L,et al.Long-term high fructose intake promotes lacrimal gland dysfunction by inducing gut dysbiosis in mice［J］.Exp Eye Res,2023,234:109573.
［6］　MOON J,CHOI S H,YOON C H,KIM M K.Gut dysbiosis is prevailing in Sjgren’s syndrome and is related to dry eye severity［J］.PLoS One,2020,15(2):e0229029.
［7］　YUN S W,SON Y H,LEE D Y,SHIN Y J,HAN M J,KIM D H.Lactobacillus plantarum and Bifidobacterium bifidum alleviate dry eye in mice with exorbital lacrimal gland excision by modulating gut inflammation and microbiota［J］.Food Funct,2021,12(6):2489-2497.
［8］　CONNELL S,KAWASHIMA M,NAKAMURA S,IMADA T,YAMAMOTO H,TSUBOTA K,et al.Lactoferrin ameliorates dry eye disease potentially through enhancement of short-chain fatty acid production by gut microbiota in mice［J］.Int J Mol Sci,2021,22(22):12384.
［9］　YE Z,ZHANG N,WU C,ZHANG X,WANG Q,HUANG X,et al.A metagenomic study of the gut microbiome in Behcet’s disease［J］.Microbiome,2018,6(1):135.
［10］　YE Z,WU C,ZHANG N,DU L,CAO Q,HUANG X,et al.Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease［J］.Gut Microbes,2020,11(3):539-555.
［11］　KALYANA CHAKRAVARTHY S,JAYASUDHA R,SAI PRASHANTHI G,ALI M H,SHARMA S,TYAGI M,et al.Dysbiosis in the gut bacterial microbiome of patients with uveitis,an inflammatory disease of the eye［J］.Indian J Microbiol,2018,58(4):457-469.
［12］　HORAI R,ZRATE-BLADS C R,DILLENBURG-PILLA P,CHEN J,KIELCZEWSKI J L,SILVER P B,et al.Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site［J］.Immunity,2015,43(2):343-353.
［13］　NAKAMURA Y K,METEA C,KARSTENS L,ASQUITH M,GRUNER H,MOSCIBROCKI C,et al.Gut microbial alterations associated with protection from autoimmune uveitis［J］.Invest Ophthalmol Vis Sci,2016,57(8):3747-3758.
［14］　NAKAMURA Y K,JANOWITZ C,METEA C,ASQUITH M,KARSTENS L,ROSENBAUM J T,et al.Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine［J］.Sci Rep,2017,7(1):11745.
［15］　任虹,孙宽,孙丽敏,王晓媛,王林.盐反应性肠道共调节Th17细胞在实验性自身免疫性葡萄膜炎发病中的作用［J］.哈尔滨医科大学学报,2022,56(6):535-540.
REN H,SUN K,SUN L M,WANG X Y,WANG L.Role of salt reactive intestinal coregulatory Th17 cells in the pathogenesis of experimental autoimmune uveitis［J］.J Harbin Med Univ,2022,56(6):535-540.
［16］　LEE R,WONG T Y,SABANAYAGAM C.Epidemiology of diabetic retinopathy,diabetic macular edema and related vision loss［J］.Eye Vis (Lond),2015,2:17.
［17］　DESJARDINS D,LIU Y,CROSSON C E,ABLONCZY Z.Histone deacetylase inhibition restores retinal pigment epithelium function in hyperglycemia［J］.PLoS One,2016,11(9):e0162596.
［18］　DEWANJEE S,DUA T K,PAUL P,DEY A,VALLAMKONDU J,SAMANTA S,et al.Probiotics:evolving as a potential therapeutic option against acetaminophen-induced hepatotoxicity［J］.Biomedicines,2022,10(7):1498.
［19］　BELI E,YAN Y,MOLDOVAN L,VIEIRA C P,GAO R,DUAN Y,et al.Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice［J］.Diabetes,2018,67(9):1867-1879.
［20］　CAI Y,KANG Y.Gut microbiota and metabolites in diabetic retinopathy:insights into pathogenesis for novel therapeutic strategies［J］.Biomed Pharmacother,2023,164:114994.
［21］　PRASAD R,ASARE-BEDIKO B,HARBOUR A,FLOYD J L,CHAKRABORTY D,DUAN Y,et al.Microbial signatures in the rodent eyes with retinal dysfunction and diabetic retinopathy［J］.Invest Ophthalmol Vis Sci,2022,63(1):5.
［22］　ZINKERNAGEL M S,ZYSSET-BURRI D C,KELLER I,BERGER L E,LEICHTLE A B,LARGIADR C R,et al.Association of the intestinal microbiome with the development of neovascular age-related macular degeneration［J］.Sci Rep,2017,7:40826.
［23］　ANDRIESSEN E M,WILSON A M,MAWAMBO G,DEJDA A,MILOUDI K,SENNLAUB F,et al.Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization［J］.EMBO Mol Med,2016,8(12):1366-1379.
［24］　ZHANG J Y,XIE B,BARBA H,NADEEM U,MOVAHEDAN A,DENG N,et al.Absence of gut microbiota is associated with RPE/choroid transcriptomic changes related to age-related macular degeneration pathobiology and decreased choroidal neovascularization［J］.Int J Mol Sci,2022,23(17):9676.
［25］　贾茜钰,刘军.基于肠道菌群论治脾虚型年龄相关性黄斑变性［J］.中国中医眼科杂志,2022,32(7):567-570.
JIA X Y,LIU J.Discussion on treatment of macular degeneration in spleen deficiency syndrome based on intestinal flora［J］.China J Chin Ophthalmol,2022,32(7):567-570.
［26］　CHEN H,CHO K S,KHANH VU T H K,SHEN C H,KAUR M,CHEN G,et al.Author Correction:Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma［J］.Nat Commun,2018,9(1):3914.
［27］　FAFURE A A,EDEM E E,OBISESAN A O,ENYE L A,ADEKEYE A O,ADETUNJI A E,et al.Fermented maize slurry (Ogi) and its supernatant (Omidun) mitigate elevated intraocular pressure by modulating BDNF expression and glial plasticity in the retina-gut axis of glaucomatous rats［J］.J Complement Integr Med,2022,19(4):887-896.
［28］　SKRZYPECKI J,IZDEBSKA J,KAMI〖KG-\*3〗N〖DD(-\*3/5〗＇SKA A,BADOWSKA J,PRZYBEK-SKRZYPECKA J,BOMBUY J,et al.Glaucoma patients have an increased level of trimethylamine,a toxic product of gut bacteria,in the aqueous humor:a pilot study［J］.Int Ophthalmol,2021,41(1):341-347.
［29］　ZHANG Y,ZHOU X,LU Y.Gut microbiota and derived metabolomic profiling in glaucoma with progressive neurodegeneration［J］.Front Cell Infect Microbiol,2022,12:968992.
［30］　HE C,PENG C,WANG H,OUYANG Y,ZHU Z,SHU X,et al.The eradication of Helicobacter pylori restores rather than disturbs the gastrointestinal microbiota in asymptomatic young adults［J］.Helicobacter,2019,24(4):e12590.
［31］　PAPAEFTHYMIOU A,DOULBERIS M,KATSINELOS P,LIATSOS C,POLYZOS S A,KOTRONIS G,et al.Impact of nitric oxide’s bidirectional role on glaucoma:focus on Helicobacter pylori-related nitrosative stress［J］.Ann N Y Acad Sci,2020,1465(1):10-28.
［32］　KOUNTOURAS J,MYLOPOULOS N,CHATZOPOULOS D,ZAVOS C,BOURA P,KONSTAS A G,et al.Eradication of Helicobacter pylori may be beneficial in the management of chronic open-angle glaucoma［J］.Arch Intern Med,2002,162(11):1237-1244.
［33］　KALYANA CHAKRAVARTHY S,JAYASUDHA R,RANJITH K,DUTTA A,PINNA N K,MANDE S S,et al.Alterations in the gut bacterial microbiome in fungal Keratitis patients［J］.PLoS ONE,2018,13(6):e0199640.
［34］　LIU K,WU P,ZOU J,FAN H,HU H,CHENG Y,et al.Mendelian randomization analysis reveals causal relationships between gut microbiome and optic neuritis［J］.Hum Genet,2023,142(8):1139-1148.
［35］　ZYSSET-BURRI D C,MORANDI S,HERZOG E L,BERGER L E,ZINKERNAGEL M S.The role of the gut microbiome in eye diseases［J］.Prog Retin Eye Res,2023,92:101117.
［36］　王雪.非诺贝特对高脂饮食小鼠视网膜损伤的影响及其机制研究［D］.长沙:中南大学,2022.
WANG X.The Study on the Effect and Its Mechanism of Fenofibrate on the Retinal Damage in High-Fat Diet-Induced Mice［D］.Changsha:Central South University,2022.

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备注/Memo

备注/Memo:
国家自然科学基金项目（编号：82305322，82104937）；国家重点研发计划项目（编号：2021YFC2702103，2019YFC1710200）；山东省中医药科技发展项目（编号：M-2022162）；山东省自然科学基金项目（编号：ZR2020QH314）；山东省中西医结合专病防治项目（编号：YXH2019ZXY001)
更新日期/Last Update: 2024-04-30