[1]蔡梦霞,魏婷婷,朱凌鹏,等.细胞衰老在干性年龄相关性黄斑变性中的作用研究进展[J].眼科新进展,2024,44(4):324-328.[doi:10.13389/j.cnki.rao.2024.0063]
　CAI Mengxia,WEI Tingting,ZHU Lingpeng,et al.Research progress on the role of cell aging in dry age-related macular degeneration[J].Recent Advances in Ophthalmology,2024,44(4):324-328.[doi:10.13389/j.cnki.rao.2024.0063]
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细胞衰老在干性年龄相关性黄斑变性中的作用研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
44卷
期数:
2024年4期
页码:
324-328
栏目:
文献综述
出版日期:
2024-04-05

文章信息/Info

Title:
Research progress on the role of cell aging in dry age-related macular degeneration
作者:
蔡梦霞; 魏婷婷; 朱凌鹏; 姚勇
214023　江苏省无锡市，南京医科大学附属无锡人民医院眼科，南京医科大学无锡医学中心（蔡梦霞，姚勇）；214023　江苏省无锡市，南京医科大学附属无锡人民医院临床研究中心，南京医科大学无锡医学中心（魏婷婷，朱凌鹏）
Author(s):
CAI Mengxia1; WEI Tingting2; ZHU Lingpeng2; YAO Yong1
1.Department of Ophthalmology,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi Medical Center,Nanjing Medical University,Wuxi 214023,Jiangsu Province,China
2.Center of Clinical Research,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi Medical Center,Nanjing Medical University,Wuxi 214023,Jiangsu Province,China
关键词:
年龄相关性黄斑变性; 细胞衰老; 视网膜色素上皮细胞; 小胶质细胞; 脉络膜血管内皮细胞; 线粒体; 溶酶体; 炎症
Keywords:
age-related macular degeneration;  cell aging;  retinal pigment epithelial cells;  microglia;  choroidal vascular endothelial cells;  mitochondria;  lysosome;  inflammation
分类号:
R774.5
DOI:
10.13389/j.cnki.rao.2024.0063
文献标志码:
A
摘要:
干性年龄相关性黄斑变性 (AMD) 是一种视网膜黄斑区域的退行性疾病，各种视网膜和脉络膜组织的衰老变化是AMD致病的重要因素之一。细胞衰老是细胞在某些生理过程中或受到应激性损伤时引发的不可逆的细胞周期停滞状态，影响多种生理和病理过程。越来越多的研究表明，细胞衰老在AMD的发生发展中起重要作用。本文就细胞衰老的机制及其与干性AMD的关系进行综述，旨在为干性AMD治疗提供新思路。
Abstract:
Dry age-related macular degeneration (AMD) is a degenerative disease affecting the macular region of the retina, and aging changes in retinal and choroidal tissues are an important factor in AMD pathogenesis. Cell aging is an irreversible state of cell cycle arrest triggered by certain physiological processes or stressful injury, affecting a variety of physiological and pathological processes. An increasing number of studies have shown that cell aging plays an essential role in the occurrence and development of AMD. This paper reviews the mechanisms of cell aging and its relationship with dry AMD, aiming to provide new ideas for the treatment of dry AMD.

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备注/Memo

备注/Memo:
国家自然科学基金（编号：82201220）；2020年度“太湖人才计划”顶尖医学专家团队（编号：2020-THRCTD-1）
更新日期/Last Update: 2024-04-05