[1]覃莞芸,邵正波.小胶质细胞极化在青光眼视神经损伤发病机制及治疗中的研究进展[J].眼科新进展,2022,42(2):155-158.[doi:10.13389/j.cnki.rao.2022.0032]
　QIN Wanyun,SHAO Zhengbo.Research progress of microglial polarization in pathogenesis and treatment of glaucoma-induced optic nerve injury[J].Recent Advances in Ophthalmology,2022,42(2):155-158.[doi:10.13389/j.cnki.rao.2022.0032]
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小胶质细胞极化在青光眼视神经损伤发病机制及治疗中的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年2期
页码:
155-158
栏目:
文献综述
出版日期:
2022-02-05

文章信息/Info

Title:
Research progress of microglial polarization in pathogenesis and treatment of glaucoma-induced optic nerve injury
作者:
覃莞芸; 邵正波
150086　黑龙江省哈尔滨市，哈尔滨医科大学附属第二医院眼科（覃莞芸，邵正波）；150086　黑龙江省哈尔滨市，哈尔滨医科大学附属第二医院未来医学实验室（覃莞芸，邵正波）
Author(s):
QIN Wanyun1; 2; SHAO Zhengbo1; 2
1.Department of Ophthalmology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang Province,China
2.Future Medical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang Province,China
关键词:
青光眼; 小胶质细胞; 极化; 视神经损伤; 炎症
Keywords:
glaucoma;  microglia;  polarization;  optic nerve injury;  inflammation
分类号:
R775
DOI:
10.13389/j.cnki.rao.2022.0032
文献标志码:
A
摘要:
青光眼是多因素介导的以视网膜神经节细胞凋亡、视神经萎缩和视野缺损为特征的神经退行性眼病，发病机制尚不明确。小胶质细胞是视网膜内常驻的免疫细胞，它可分为经典激活M1型和替代激活M2型，随着眼压改变以及视网膜神经节细胞损伤修复过程的进展，小胶质细胞的极性呈现动态变化，可产生多种具有神经毒性或神经保护作用的细胞因子。近年来，维持小胶质细胞极性稳态、减少过度免疫应答成为延缓青光眼视神经退行性病变进展的重要策略。本文就小胶质细胞的生理学特征、极化，小胶质细胞极化与青光眼的关系以及目前以小胶质细胞极化为靶点的治疗策略作一综述。
Abstract:
Glaucoma is a multifactorial neurodegenerative eye disease with symptoms of retinal ganglion cell (RGC) apoptosis, optic atrophy, and visual field loss. However, its pathogenesis is still unclear. Microglia are resident immune cells in the retina and can be divided into classically activated M1 type and alternatively activated M2 type. As the intraocular pressure changes and the repair of RGC injury advances, microglia will show dynamic changes in polarity and produce a variety of cytokines with neurotoxic or neuroprotective effects. In recent years, maintaining stable microglia polarity and reducing excessive immune response have become important strategies to delay optic nerve degeneration in glaucoma. This article reviews the physiological characteristics and polarity of microglia, the relationship between microglial polarization and glaucoma, and current therapies targeting microglial polarization.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81970799，81870654）；黑龙江省博士后科研启动基金（编号：LBH-Q18082）
更新日期/Last Update: 2022-02-05