[1]张丽娟,梁荣斌,邵毅.维生素D缺乏与干眼关系的研究进展[J].眼科新进展,2021,41(8):794-796.[doi:10.13389/j.cnki.rao.2021.0166]
　ZHANG Lijuan,LIANG Rongbin,SHAO Yi.Relationship between vitamin D deficiency and dry eye disease[J].Recent Advances in Ophthalmology,2021,41(8):794-796.[doi:10.13389/j.cnki.rao.2021.0166]
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维生素D缺乏与干眼关系的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年8期
页码:
794-796
栏目:
文献综述
出版日期:
2021-08-05

文章信息/Info

Title:
Relationship between vitamin D deficiency and dry eye disease
作者:
张丽娟; 梁荣斌; 邵毅
330006　江西省南昌市，南昌大学第一附属医院眼科
Author(s):
ZHANG Lijuan; LIANG Rongbin; SHAO Yi
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
关键词:
干眼; 维生素D; 炎症
Keywords:
dry eye;  vitamin D;  inflammation
分类号:
R772
DOI:
10.13389/j.cnki.rao.2021.0166
文献标志码:
A
摘要:
干眼是泪液和眼球表面的多因素疾病，能引起不适、视觉障碍和泪膜不稳定，可能损害眼表，伴有泪液渗透压升高和眼表炎症。维生素D是一种脂溶性维生素，在皮肤中产生或随食物摄取,具有多种功能，对骨骼、肠道、肾脏，特别是免疫系统等有重要的调节作用。近年研究发现，维生素D缺乏与干眼存在密切联系。本文就维生素D缺乏与干眼之间的关系进行综述。
Abstract:
Dry eye is a multifactorial disease of tear and ocular surface that can cause ocular discomfort, visual impairment and tear film instability with potential ocular surface damage, increased tear osmolality and ocular surface inflammation. Vitamin D is a lipid-soluble vitamin produced in the skin or ingested with food. It has a variety of functions and plays an important role in the regulation of bone, intestine, kidney, especially the immune system. Recent studies have found that Vitamin D deficiency is closely related to DE. This paper reviews the relationship between vitamin D deficiency and DE.

参考文献/References:

［1］　CRAIG J P,NICHOLS K K,AKPEK E K,CAFFERY B,DUA H S,JOO C K,et al.TFOS DEWS II definition and classification report［J］.Ocul Surf,2017,15(3):276-283.
［2］　BRON A J,DE PAIVA C S,CHAUHAN S K,BONINI S,GABISON E E,JAIN S,et al.TFOS DEWS II pathophysiology report［J］.Ocul Surf,2017,15(3):438-510.
［3］　GANESALINGAM K,ISMAIL S,SHERWIN T,CRAIG J P.Molecular evidence for the role of inflammation in dry eye disease［J］.Clin Exp Optom,2019,102(5):446-454.
［4］　BARABINO S,CHEN Y,CHAUHAN S,DANA R.Ocular surface immunity:homeostatic mechanisms and their disruption in dry eye disease［J］.Prog Retin Eye Res,2012,31(3):271-285.
［5］　邵毅,石文卿.2018美国眼科学会干眼指南解读［J］.眼科新进展,2019,39(12):1101-1104,1110.
SHAO Y,SHI W Q.Interpretation of 2018 dry eye syndrome preferred practice pattern(DEsPPP)［J］.Rec Adv Ophthalmol,2019,39(12):1101-1104,1110.
［6］　WANG Z Y,WANG Y,XU B X,LIU J L,REN Y,DAI Z J,et al.Vitamin D improves immune function in immunosuppressant mice induced by glucocorticoid［J］.Biomed Rep,2017,6(1):120-124.
［7］　VELDMAN C M,CANTORNA M T,DELUCA H F.Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system［J］.Arch Biochem Biophys,2000,374(2):334-338.
［8］　LEE J H,KIM S J,BYUN Y S,LEE J,PARK S H,CHUNG S H.The association of serum vitamin D level with the severity of dry eye parameters in primary sjgren syndrome［J］.Cornea,2020,39(6):702-705.
［9］　KURTUL B E,ZER P A,AYDINLI M S.The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjgren dry eye［J］.Eye (Lond),2015,29(8):1081-1084.
［10］　DIKCI S,AKATLI A N,YILDIRIM T.Conjunctival impression cytology and tear-film changes in cases with vitamin D deficiency［J］.Int Ophthalmol,2020,40(7):1687-1694.
［11］　SHETTY R,DESHPANDE K,DESHMUKH R,JAYADEV C,SHROFF R.Bowman break and subbasal nerve plexus changes in a patient with dry eye presenting with chronic ocular pain and vitamin D deficiency［J］.Cornea,2016,35(5):688-691.
［12］　JIE Y,XU L,WU Y Y,JONAS J B.Prevalence of dry eye among adult Chinese in the Beijing Eye Study［J］.Eye (Lond),2009,23(3):688-693.
［13］　ZHANG S,HONG J.Risk factors for dry eye in mainland China:a multi-center cross-sectional hospital-based study［J］.Ophthalmic Epidemiol,2019,26(6):393-399.
［14］　RAPOPORT Y,SINGER J M,LING J D,GREGORY A,KOHANIM S. A comprehensive review of sex disparities in symptoms,pathophysiology,and epidemiology of dry eye syndrome［J］.Semin Ophthalmol,2016,31(4):325-336.
［15］　SHETTY R,SETHU S,DESHMUKH R,DESHPANDE K,GHOSH A,AGRAWAL A,et al.Corneal dendritic cell density is associated with subbasal nerve plexus features,ocular surface disease index,and serum vitamin D in evaporative dry eye disease［J］.Biomed Res Int,2016:4369750.
［16］　杨玉洁,相义会.25-羟基维生素D与干眼的相关性研究［J］.眼科新进展,2017,37(12):1165-1168.
YANG Y J,XIANG Y H.Association of 25-hydroxyvitamin D with dry eye［J］.Rec Adv Ophthalmol,2017,37(12):1165-1168.
［17］　GOLTZMAN D,MANNSTADT M,MARCOCCI C.Physiology of the Calcium-Parathyroid Hormone-Vitamin D axis［J］.Front Horm Res,2018,50:1-13.
［18］　KOIVISTO O,HANEL A,CARLBERG C.Key vitamin D target genes with functions in the immune system［J］.Nutrients,2020,12(4):1140.
［19］　JOHNSON J A,GRANDE J P,ROCHE P C,CAMPBELL R J,KUMAR R.Immuno-localization of the calcitriol receptor,calbindin-D28k and the plasma membrane Calcium pump in the human eye［J］.Curr Eye Res,1995,14(2):101-108.
［20］　ZHANG Z,CHEN F,LI J,LUO F,HOU T,XU J,et al.1,25(OH)2D3 suppresses proinflammatory responses by inhibiting Th1 cell differentiation and cytokine production through the JAK/STAT pathway［J］.Am J Transl Res,2018,10(8):2737-2746.
［21］　DANKERS W,DAVELAAR N,VAN HAMBURG J P,VAN DE PEPPEL J,COLIN E M,LUBBERTS E.Human memory Th17 cell populations change into anti-inflammatory cells with regulatory capacity upon exposure to active vitamin D［J］.Front Immunol,2019,10:1504.
［22］　YANG C H,ALBIETZ J,HARKIN D G,KIMLIN M G,SCHMID K L.Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D［J］.Cont Lens Anterior Eye,2018,41(1):69-76.
［23］　YIN Z,PINTEA V,LIN Y,HAMMOCK B D,WATSKY M.Vitamin D enhances corneal epithelial barrier function［J］.Invest Ophthalmol Vis Sci,2011,52(10):7359-7364.
［24］　PAZ H B,TISDALE A S,DANJO Y,SPURR-MICHAUD S J,ARGESO P,GIPSON I K.the role of Calcium in mucin packaging within goblet cells［J］.Exp Eye Res,2003,77(1):69-75.
［25］　KIZILGUL M,KAN S,OZCELIK O,BEYSEL S,APAYDIN M,UCAN B,et al.Vitamin D replacement improves tear osmolarity in patients with vitamin D deficiency［J］.Semin Ophthalmol,2018,33(5):589-594.
［26］　EKSIOGLU U,ATILGAN H I,YAKIN M,YAZIHAN N,ALTIPARMAK U E,YUMUSAK N,et al.Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model［J］.Cutan Ocul Toxicol,2019,38(1):18-24.
［27］　DAI Y,ZHANG J,XIANG J,LI Y,WU D,XU J.Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells［J］.Redox Biol,2019,21:101093.
［28］　ZHANG J,DAI Y,WU D,XU J.Calcitriol,the active metabolite of vitamin D(3),inhibits dry eye related corneal inflammation in vivo and in vitro［J］.Ocul Immunol Inflamm,2019,27(2):257-265.
［29］　HWANG J S,LEE Y P,SHIN Y J.Vitamin D enhances the efficacy of topical artificial tears in patients with dry eye disease［J］.Cornea,2019,38(3):304-310.
［30］　JEON D H,YEOM H,YANG J,SONG J S,LEE H K,KIM H C.Are serum vitamin D levels associated with dry eye disease?Results from the study group for environmental eye disease［J］.J Prev Med Public Health,2017,50(6):369-376.
［31］　KIM M J,HWANG H R,KIM Y J,LEE S Y,LEE J G,JEONG D W,et al.Association between serum 25-Hydroxyvitamin D levels and dry eye in korean adults:a study based on Korean national health and nutrition examination survey,2010-2011［J］.Korean J Fam Med,2017,38(2):81-85.
［32］　JEE D,KANG S,YUAN C,CHO E,ARROYO J G.Epidemiologic survey committee of the korean ophthalmologic society.serum 25-Hydroxyvitamin D levels and dry eye syndrome:differential effects of vitamin D on ocular diseases［J］.PLoS One,2016,11(2):e0149294.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81660158）；江西省重点研发项目（编号： 20181BBG70004）; 江西省杰出青年人才计划（编号：20192BCBL23020）；江西省基层卫生适宜技术“星火推广计划”项目（编号：20188003）；江西省卫计委科技计划面上项目（编号：20175116，20201032）；江西省卫计委中医药科技计划项目（编号：2018A060）
更新日期/Last Update: 2021-08-05