[1]胡利,闻毅颐,李东豪.普拉洛芬滴眼液联合角膜绷带镜治疗复发性角膜上皮糜烂[J].眼科新进展,2021,41(6):566-569.[doi:10.13389/j.cnki.rao.2021.0118]
　HU Li,WEN Yiyi,LI Donghao.Pranoprofen eye drops and bandage contact lens for recurrent corneal erosion syndrome[J].Recent Advances in Ophthalmology,2021,41(6):566-569.[doi:10.13389/j.cnki.rao.2021.0118]
点击复制

普拉洛芬滴眼液联合角膜绷带镜治疗复发性角膜上皮糜烂/HTML
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年6期
页码:
566-569
栏目:
应用研究
出版日期:
2021-06-05

文章信息/Info

Title:
Pranoprofen eye drops and bandage contact lens for recurrent corneal erosion syndrome
作者:
胡利; 闻毅颐; 李东豪
510150　广东省广州市，广州医科大学附属第三医院眼科
Author(s):
HU Li; WEN Yiyi; LI Donghao
Department of Ophthalmology,the Third Affiliated Hospital of Guangzhou Medical University，Guangzhou 510150，Guangdong Province,China
关键词:
普拉洛芬; 复发性角膜上皮糜烂; 角膜绷带镜
Keywords:
Pranoprofen;  recurrent corneal erosion syndrome;  bandage contact lens
分类号:
R772.21
DOI:
10.13389/j.cnki.rao.2021.0118
文献标志码:
A
摘要:
目的　研究普拉洛芬滴眼液联合角膜绷带镜治疗复发性角膜上皮糜烂的有效性。方法　选择63例（63眼）复发性角膜上皮糜烂患者，按治疗方法不同分为普拉洛芬组（32例32眼）及对照组（31例31眼）。两组均配戴角膜绷带镜，并每2周更换一次，持续3个月。治疗时两组患眼均使用左氧氟沙星滴眼液和玻璃酸钠滴眼液滴眼，普拉洛芬组还加用普拉洛芬滴眼液滴眼，所有滴眼液均应用3个月。记录两组患眼治疗前及治疗后3个月的最佳矫正视力（BCVA）；于治疗后3 d、7 d、1个月及3个月使用视觉模拟评分法（VAS）记录患眼VAS评分；于治疗后3 d、第1个月内的每周及第2个月、第3个月内的每两周行前节OCT检查了解角膜愈合情况，记录角膜愈合时间。对治愈患者进行2年随访，以观察复发情况。结果　普拉洛芬组与对照组患者年龄、性别比例、病因分布及既往复发次数比较，差异均无统计学意义（均为P>0.05）。普拉洛芬组患眼治疗前、治疗后3个月BCVA分别为4.39±0.13和4.76±0.11，对照组患眼治疗前、治疗后3个月BCVA分别4.39±0.15 和4.75±0.15，两组患眼治疗后BCVA均较治疗前提高，差异均有统计学意义（t=37.350、25.044，均为P<0.05），两组患眼间治疗前、治疗后3个月BCVA差异均无统计学意义（均为P>0.05）。两组患眼组内治疗前、治疗后各随访时间点间VAS评分两两比较，差异均有统计学意义（均为P<0.05）。两组患眼组间治疗前及治疗后3 d、7 d、1个月、3个月VAS评分比较，差异均无统计学意义（均为P>0.05）。普拉洛芬组、对照组患眼角膜愈合时间分别为（6.63±2.76）周、（5.07±1.86）周，差异有统计学意义（t=2.625，P=0.011）。普拉洛芬组患眼复发率（9.38%）与对照组患眼复发率（29.03%）比较，差异有统计学意义（P<0.05）。结论　普拉洛芬滴眼液联合角膜绷带镜治疗复发性角膜上皮糜烂患眼的角膜愈合时间略长，但拥有更低的复发率。
Abstract:
Objective　To assess the efficacy of pranoprofen eye drops combined with bandage contact lens in the treatment of recurrent corneal erosion syndrome (RCES).Methods　Sixty-three patients (63 eyes) with RCES were divided into two groups: Pranoprofen group (32 patients, 32 eyes) and control group (31 patients, 31 eyes). Both groups wore bandage contact lens and changed them every 2 weeks until 3 months. Levofloxacin eye drops and sodium hyaluronate eye drops were used in both groups, while Pranoprofen eye drops were only used in Pranoprofen group. All eye drops were used for 3 months. The best corrected visual acuity (BCVA) were recorded before and 3 months after treatment. Visual analogue score (VAS) were recorded on day 3, 7, the first and third month after treatment. Anterior segment OCT was performed for corneal healing check on day 3, weekly in the first month, and every two weeks in the second and third months. The cured patients were followed up for 2 years to observe the recurrence.Results　There were no statistically significant differences in age, gender ratio, etiological distribution, and previous recurrence times between the Pranoprofen group and the control group (all P>0.05). The BCVA before and 3 months after treatment was 4.39±0.13 and 4.76±0.11 in Pranoprofen group respectively, while that in the control group was 4.39±0.15 and 4.75±0.15,respectively. The BCVA after treatment in both groups was higher than that before treatment, and the differences were statistically significant (t=37.350, 25.044, both P<0.05). There was no significant difference in BCVA between the two groups before and 3 months after treatment (both P>0.05). There were statistically significant differences in VAS at each follow-up time point within the both groups (all P<0.05). There were no statistically significant differences in VAS on day 3, 7, 1 month and 3 months after treatment between the two groups (all P>0.05). The corneal healing time of patients was (6.63±2.76) weeks and (5.07±1.86) weeks in Pranoprofen group and control group, respectively, and the difference was statistically significant (t=2.625, P=0.011). The recurrence rate of Pranoprofen group (9.38%) was significantly lower than that of control group (29.03%) (P<0.05).Conclusion　Pranoprofen eye drops combined with bandage contact lens in the treatment of RCES has a slightly long healing time, but has a low recurrence rate.

参考文献/References:

［1］　TRUFANOV S V.Recurrent corneal erosion:modern view of the problem［J］.Vestn Oftalmol,2020,136（2）:317-324.
［2］　LIN S R,ALDAVE A J,CHODOSH J.Recurrent corneal erosion syndrome［J］.Br J Ophthalmol,2019,103(9):1204-1208.
［3］　PASTOR-VIVAS A I,ALEJANDRE-ALBA N,GARCA-VEGA M I,ARIO-GUTIRREZ M,GARCA-SANDOVAL B,JIMNEZ-ALFARO I.Quantifying and classifying postsurgical pain in pterygium surgery with conjunctival autografts［J］.Arch Soc Esp Oftalmol,2011,86(6):176-179.
［4］　HEYWORTH P,MORLET N,RAYNER S,HYKIN P,DART J.Natural history of recurrent erosion syndrome:a 4 year review of 117 patients［J］.Br J Ophthalmol,1998,82(1):26-28.
［5］　BONINI S,LAMBIASE A,RAMA P,SINIGAGLIA F,ALLEGRETTI M,CHAO W,et al.Phase II randomized,double-masked,vehiclecontrolled trial of recombinant human nerve growth factor for neurotrophic keratitis［J］.Ophthalmology,2018,125(9):1332-1343.
［6］　DI G,QI X,ZHAO X,ZHANG S,DANIELSON P,ZHOU Q.Corneal epithelium-derived neurotrophic factors promote nerve regeneration［J］.Invest Ophthalmol Vis Sci,2017,58 (11):4695-4702.
［7］　BENITEZ-DEL-CASTILLO J M,RODRGUEZ-BAYO S,FONTAN-RIVAS E,MARTINEZ-DE-LA-CASA J M,GARCIA-SANCHEZ J.Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I［J］.Arch Ophthalmol,2005,123(10):1445-1447.
［8］　AVNI ZAUBERMAN N,ARTORNSOMBUDH P,ELBAZ U,GOLDICH Y,ROOTMAN D S,CHAN C C.Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome:patient clinical features and outcomes［J］.Am J Ophthalmol,2014,157(2):273-279.
［9］　DEDES W,FAES L,SCHIPPER I,BACHMANN L M,THIEL M A.Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion:correlation between etiology and prognosis-prospective longitudinal study［J］.Graefes Arch Clin Exp Ophthalmol,2015,253(10):1745-1749.
［10］　LI J,MA Y,HUANG X,XU L,TANG S.Bandage contact lenses versus deproteinized calf blood extract eye gel for recurrent corneal erosion syndrome:a case-control study ［J］.Ther Clin Risk Manag,2020,16:1109-1115.
［11］　CHEN D,LIAN Y,LI J,MA Y,SHEN M,LU F.Monitor corneal epithelial healing under bandage contact lens using ultrahigh-resolution optical coherence tomography after pterygium surgery ［J］.Eye Contact Lens,2014,40(3):175-180.
［12］　陈娟,张暹梅.绷带型角膜接触镜与眼部药物治疗复发性角膜上皮糜烂的疗效比较［J］.南京医科大学学报(自然科学版),2014,34(11):1601-1603.
CHEN J,ZHANG X M.Comparison of bandage contact lens and ocular drugs in the treatment of recurrent corneal epithelial erosion［J］.Acta Univ Med Nanjing(Nat Sci),2014,34(11):1601-1603.
［13］　SCHMOLL T,UNTERHUBER A,KOLBITSCH C,LE T,STINGL A,LEITGEB R.Precise thickness measurements of Bowman’s layer,epithelium,and tear film［J］.Optom Vis Sci,2012,89(5):795-802.
［14］　YAO P,ZHAO J,LI M,SHEN Y,DONG Z,ZHOU X.Microdistortions in Bowman’s layer following femtosecond laser small incision lenticule extraction observed by fourier domain OCT［J］.J Refract Surg,2013,29(10):668-674.
［15］　DIEZ-FEIJO E,DURN J A.Optical coherence tomography findings in recurrent corneal erosion syndrome［J］.Cornea,2015,34(3):290-295.
［16］　CANDAR T,ASENA L,ALKAYID H,ALTINRS D D.Galectin-3,IL-1A,IL-6,and EGF levels in corneal epithelium of patients with recurrent corneal erosion syndrome［J］.Cornea,2020,39(11):1354-1358.
［17］　LJUBIMOV A V,SAGHIZADEH M.Progress in corneal wound healing［J］.Prog Retin Eye Res,2015,49(1):17-45.
［18］　王荣荣,潘华,姜玲,刘超.普拉洛芬滴眼液对白内障围手术期角膜内皮和泪液炎症因子的影响［J］.国际眼科杂志,2018,18(1):100-103.
WANG R R,PAN H,JIANG L,LIU C.Effects of pranoprofen eye drops on corneal endothelium and tears inflammatory factors in perioperative period of cataract［J］.Int Eye Sci,2018,18(1):100-103.

相似文献/References:

[1]楚静 陈忠平.普拉洛芬及羟苯磺酸钙在糖尿病患者白内障手术中的应用[J].眼科新进展,2013,33(8):000.
[2]刘明,陈珺.普拉洛芬滴眼液不同用药时间对干眼症疗效的影响[J].眼科新进展,2016,36(10):946.[doi:10.13389/j.cnki.rao.2016.0253]
　LIU Ming,CHEN Jun.Curative effects of different medication time of pranoprofen eye drops on dry eye[J].Recent Advances in Ophthalmology,2016,36(6):946.[doi:10.13389/j.cnki.rao.2016.0253]
[3]谭舟利,范玮.普拉洛芬对糖尿病患者白内障术后视力和黄斑厚度的影响[J].眼科新进展,2019,39(2):145.[doi:10.13389/j.cnki.rao.2019.0033]
　TAN Zhou-Li,FAN Wei.Effect of pranoprofen on visual acuity and macular thickness in patients with diabetes mellitus after cataract surgery[J].Recent Advances in Ophthalmology,2019,39(6):145.[doi:10.13389/j.cnki.rao.2019.0033]

备注/Memo

备注/Memo:
N/A
更新日期/Last Update: 2021-06-05