[1]李鹏飞,张国伟,曹宇,等.年龄相关性白内障患者氧化损伤修复基因表观遗传学研究进展[J].眼科新进展,2021,41(2):178-181.[doi:10.13389/j.cnki.rao.2021.0038]
　LI Pengfei,ZHANG Guowei,CAO Yu,et al.Research progress of epigenetic modification changes of oxidative damage repair genes in patients with sage-related cataract[J].Recent Advances in Ophthalmology,2021,41(2):178-181.[doi:10.13389/j.cnki.rao.2021.0038]
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年龄相关性白内障患者氧化损伤修复基因表观遗传学研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年2期
页码:
178-181
栏目:
文献综述
出版日期:
2021-02-05

文章信息/Info

Title:
Research progress of epigenetic modification changes of oxidative damage repair genes in patients with sage-related cataract
作者:
李鹏飞; 张国伟; 曹宇; 陈晓娟; 王莹; 管怀进
226001　江苏省南通市，南通大学附属医院眼科研究所
Author(s):
LI Pengfei; ZHANG Guowei; CAO Yu; CHEN Xiaojuan; WANG Ying; GUAN Huaijin
Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China
关键词:
年龄相关性白内障; 氧化损伤; 表观遗传学;  DNA甲基化; 组蛋白修饰; 非编码RNA
Keywords:
age-related cataract;  oxidative damage;  epigenetics;  DNA methylation;  histone modification;  non-coding RNA
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2021.0038
文献标志码:
A
摘要:
氧化损伤是目前较为公认的年龄相关性白内障（ARC）发病机制。晶状体上皮细胞的氧化损伤会引起DNA损伤,而DNA氧化损伤修复能力不足或不及时均会引起ARC的发生。近年来发现，许多眼睛疾患的发病机制受表观遗传、环境及遗传等因素的影响,并且表观遗传学通过调控DNA氧化损伤修复基因的表达在ARC发生机制中起重要作用。本文系统阐述了ARC中表观遗传学如何调控DNA氧化损伤修复基因，并结合本课题组的研究发现进一步探讨其研究价值。
Abstract:
Oxidative damage is the currently recognized pathogenesis of age-related cataract (ARC). Oxidative damage of lens epithelial cells (LECs) causes DNA damage. However, the insufficient or delayed repair ability of DNA oxidative damage will cause the occurrence of ARC. Recently, evidences have been found that the pathogenesis of many eye diseases is regulated by the interaction of epigenetic, environmental and genetic factors. The emergence of epigenetic studies indicates that DNA oxidative damage repair genes play an important role in the pathogenesis of ARC. This paper systematically reviews previous studies on the mechanism of epigenetics regulating DNA oxidative damage repair genes in ARC, and further explores the research value in combination with our own researches.

参考文献/References:

［1］　TANG Y,WANG X,WANG J,HUANG W,GAO Y,LUO Y,et al.Prevalence of age-related cataract and cataract surgery in a chinese adult population:the taizhou eye study［J］.Invest Ophthalmol Vis Sci,2016,57(3):1193-1200.
［2］　ZHENG L R,MA J J,ZHOU D X,AN L F,ZHANG Y Q.Association between DNA repair genes (XPD and XRCC1) polymorphisms and susceptibility to age-related cataract (ARC):a meta-analysis［J］.Graefes Arch Clin Exp Ophthalmol,2014,252(8):1259-1266.
［3］　管怀进，康丽华.白内障表观遗传学研究的现状及进展［J］.眼科新进展,2014,34（7）:601-606.
GUAN H J,KANG L H.Current situation and future development of epigenetic in cataract［J］.Rec Adv Ophthalmol,2014,34(7):601-606.
［4］　XIANG J,CHEN Q,KANG L,ZHANG G,WANG Y,QIN B,et al.LncRNA PLCD3-OT1 functions as a CeRNA to prevent age-related cataract by sponging mir-224-5p and regulating PLCD3 expression［J］.Invest Ophthalmol Vis Sci,2019,60(14):4670-4680.
［5］　WANG Y,LI F,ZHANG G,KANG L,QIN B,GUAN H.Altered DNA methylation and expression profiles of 8-Oxoguanine DNA glycosylase 1 in lens tissue from age-related cataract patients［J］.Curr Eye Res,2015,40(8):815-821.
［6］　LI F,WANG Y,ZHANG G,ZHOU J,YANG L,GUAN H.Expression and methylation of DNA repair genes in lens epithelium cells of age-related cataract［J］.Mutat Res,2014,766-767：31-36.
［7］　WANG Y,LI F,ZHANG G,KANG L,GUAN H.Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation［J］.Clin Epigenetics,2016,8:62.
［8］　ZHANG J.Brothers in arms:emerging roles of RNA epigene-tics in DNA damage repair［J］.Cell Biosci,2017,7:24.
［9］　WIGGS J L.The cell and molecular biology of complex forms of glaucoma:updates on genetic,environmental,and epigenetic risk factors［J］.Invest Ophthalmol Vis Sci,2012,53(5):2467-2469.
［10］　张又嘉，陈宇虹，雷苑.表观遗传调控与青光眼发病机制研究进展［J］.眼科新进展，2019，39（5）：477-481.
ZHANG Y J,CHEN Y H,LEI Y.Progress in epigenetics and glaucoma［J］.Rec Adv Ophthalmol,2019,39(5):477-481.
［11］　HUNTER A,SPECHLER P A,CWANGER A,SONG Y,ZHANG Z,YING G S,et al.DNA methylation is associated with altered gene expression in AMD［J］.Invest Ophthalmol Vis Sci,2012,53(4):2089-2105.
［12］　MCCARTHY N.Retinoblastoma:Epigenetic outcome［J］.Nat Rev Cancer,2012,12(2):80.
［13］　SHARMA S,KELLY TK,JONES P A.Epigenetics in cancer［J］.Carcinogenesis,2010,31(1):27-36.
［14］　BOYES J,BIRD A.DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein［J］.Cell,1991,64(6):1123-1134.
［15］　ZHU X,ZHANG G,KANG L,GUAN H.Epigenetic regulation of werner syndrome gene in age-related cataract［J］.J Ophthalmol,2015,2015(24):579695.
［16］　CHEN Q W,ZHU X Y,LI Y Y,MENG Z Q.Epigenetic regulation and cancer (review)［J］.Oncol Rep,2014,31(2):523-532.
［17］　PERRI F,LONGO F,GIULIANO M,SABBATINO F,FAVIA G,IONNA F,et al.Epigenetic control of gene expression:Potential implications for cancer treatment［J］.Crit Rev Oncol Hematol,2017,111:166-172.
［18］　EGGER G,LIANG G,APARICIO A,JONES P A.Epigenetics in human disease and prospects for epigenetic therapy［J］.Nature,2004,429(6990):457-463.
［19］　LI B,ZHOU J,ZHANG G,WANG Y,KANG L,WU J,et al.Relationship between the altered expression and epigenetics of GSTM3 and age-related cataract［J］.Invest Ophthalmol Vis Sci,2016,57(11):4721-4732.
［20］　BEERMANN J,PICCOLI M T,VIERECK J,THUM T.Non-coding RNAs in development and disease:background,mechanisms,and therapeutic approaches［J］.Physiol Rev,2016,96(4):1297-1325.
［21］　ASHWAL-FLUSS R,MEYER M,PAMUDURTI N R,IVANOV A,BARTOK O,HANAN M,et al.circRNA biogenesis competes with pre-mRNA splicing［J］.Mol Cell,2014,56(1):55-66.
［22］　STARKE S,JOST I,ROSSBACH O,SCHNEIDER T,SCHREINER S,HUNG L H,et al.Exon circularization requires canonical splice signals［J］.Cell Rep,2015,10(1):103-111.
［23］　FAN C,LIU X,LI W,WANG H,TENG Y,REN J,et al.Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function［J］.Gene,2019,710:170-177.
［24］　CHENG T,XU M,QIN B,WU J,TU Y,KANG L,et al.lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis［J］.J Cell Mol Med,2019,23(9):6131-6139.
［25］　JIA Y,NIE F,DU A,CHEN Z,QIN Y,HUANG T,et al.Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP［J］.J Mol Cell Biol,2014,6(3):231-239.
［26］　LI Z,GU T P,WEBER A R,SHEN J Z,LI B Z,XIE Z G,et al.Gadd45a promotes DNA demethylation through TDG［J］.Nucleic Acids Res,2015,43(8):3986-3997.
［27］　XIANG S Y,OUYANG K,YUNG B S,MIYAMOTO S,SMRCKA A V,CHEN J,et al.PLCepsilon,PKD1,and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart［J］.Sci Signal,2013,6(306):108.
［28］　TU Y,LI L,QIN B,WU J,CHENG T,KANG L,et al.Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract［J］.Mol Vis,2019,25:734-744.
［29］　KANG L,ZOU X,ZHANG G,XIANG J,WANG Y,YANG M,et al.A variant in a microRNA binding site in NEIL2 3’UTR confers susceptibility to age-related cataracts［J］.FASEB J,2019,33(9):10469-10476.
［30］　LI G,SONG H,CHEN L,YANG W,NAN K,LU P.TUG1 promotes lens epithelial cell apoptosis by regulating miR-421/caspase-3 axis in age-related cataract［J］.Exp Cell Res,2017,356(1):20-27.
［31］　LIU X,LIU B,ZHOU M,FAN F,YU M,GAO C,et al.Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis［J］.Biochem Biophys Res Commun,2018,503(4):2277-2285.

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备注/Memo

备注/Memo:
国家自然科学基金面上项目（编号：81770906、81974129）
更新日期/Last Update: 2021-02-05